Exemplar Abstract for Thiosymbion oneisti (sic) Petersen et al. 2017 and Thiosymbium laxi corrig. Petersen et al. 2017.

Parker, Charles Thomas; Garrity, George M

doi:10.1601/ex.34317

Cited by 5 publications

(14 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endogenous agonists Peptides derived from the Stachel sequence: THFGVLMDLPRSASQL [1388] -Comments ADGRG6 is a key regulator of Schwann cell-mediated myelination [1619], and couples to G s and G i/o pathways [1388,1606,1861]. Apomorphine hydrochloride is an exogenous agonist [237].…”

Section: Principal Signal Transduction Involvesmentioning

confidence: 99%

“…cadherins, immunolobulin, lectins) facilitating inter-and matricellular interactions and leading to the term adhesion GPCR [669,2638]. Several receptors have been suggested to function as mechanosensors [233,1861,2094,2545]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [845].…”

Section: G Protein-coupled Receptors → Adhesion Class Gpcrsmentioning

confidence: 99%

“…Apomorphine hydrochloride is an exogenous agonist [237]. Binds to Laminin-211 [1861]. ADGRG6 is essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons [1606,1619,1620,1861] and for proper heart development [1826,2470].…”

Section: Principal Signal Transduction Involvesmentioning

confidence: 99%

“…Binds to Laminin-211 [1861]. ADGRG6 is essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons [1606,1619,1620,1861] and for proper heart development [1826,2470]. Further, conditional deletion of Adgrg6 revealed that this adhesion GPCR is involved in regulation of body length and bone mass [2264] and intervertebral disc function [1423].…”

Section: Principal Signal Transduction Involvesmentioning

confidence: 99%

“…β-catenin-independent FZD signalling is far more complex with regard to the diversity of the activated pathways. WNT/FZD signalling can lead to the activation of heterotrimeric G proteins [533,1858,2100], the elevation of intracellular calcium [2191], activation of cGMP-specific PDE6 [25] and elevation of cAMP as well as RAC-1, JNK, Rho and Rho kinase signalling [860]. Novel resonance energy transfer-based tools have allowed the study of the GPCR-like nature of FZDs in greater detail.…”

Section: Class Frizzled Gpcrsmentioning

confidence: 99%

See 4 more Smart Citations

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Alexander

Christopoulos

Davenport

et al. 2021

British J Pharmacology

366

274

View full text Add to dashboard Cite

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

show abstract

Section: Principal Signal Transduction Involvesmentioning

confidence: 99%

Section: G Protein-coupled Receptors → Adhesion Class Gpcrsmentioning

confidence: 99%

Section: Principal Signal Transduction Involvesmentioning

confidence: 99%

Section: Principal Signal Transduction Involvesmentioning

confidence: 99%

Section: Class Frizzled Gpcrsmentioning

confidence: 99%

See 3 more Smart Citations

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Alexander

Christopoulos

Davenport

et al. 2021

British J Pharmacology

366

274

View full text Add to dashboard Cite

show abstract

Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins

Landry,

Ward,

Cunanan

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceIncreasing evidence suggests that, compared with an omnivorous diet, a vegan diet confers potential cardiovascular benefits from improved diet quality (ie, higher consumption of vegetables, legumes, fruits, whole grains, nuts, and seeds).ObjectiveTo compare the effects of a healthy vegan vs healthy omnivorous diet on cardiometabolic measures during an 8-week intervention.Design, Setting, and ParticipantsThis single-center, population-based randomized clinical trial of 22 pairs of twins (N = 44) randomized participants to a vegan or omnivorous diet (1 twin per diet). Participant enrollment began March 28, 2022, and continued through May 5, 2022. The date of final follow-up data collection was July 20, 2022. This 8-week, open-label, parallel, dietary randomized clinical trial compared the health impact of a vegan diet vs an omnivorous diet in identical twins. Primary analysis included all available data.InterventionTwin pairs were randomized to follow a healthy vegan diet or a healthy omnivorous diet for 8 weeks. Diet-specific meals were provided via a meal delivery service from baseline through week 4, and from weeks 5 to 8 participants prepared their own diet-appropriate meals and snacks.Main Outcomes and MeasuresThe primary outcome was difference in low-density lipoprotein cholesterol concentration from baseline to end point (week 8). Secondary outcome measures were changes in cardiometabolic factors (plasma lipids, glucose, and insulin levels and serum trimethylamine N-oxide level), plasma vitamin B12 level, and body weight. Exploratory measures were adherence to study diets, ease or difficulty in following the diets, participant energy levels, and sense of well-being.ResultsA total of 22 pairs (N = 44) of twins (34 [77.3%] female; mean [SD] age, 39.6 [12.7] years; mean [SD] body mass index, 25.9 [4.7]) were enrolled in the study. After 8 weeks, compared with twins randomized to an omnivorous diet, the twins randomized to the vegan diet experienced significant mean (SD) decreases in low-density lipoprotein cholesterol concentration (−13.9 [5.8] mg/dL; 95% CI, −25.3 to −2.4 mg/dL), fasting insulin level (−2.9 [1.3] μIU/mL; 95% CI, −5.3 to −0.4 μIU/mL), and body weight (−1.9 [0.7] kg; 95% CI, −3.3 to −0.6 kg).Conclusions and RelevanceIn this randomized clinical trial of the cardiometabolic effects of omnivorous vs vegan diets in identical twins, the healthy vegan diet led to improved cardiometabolic outcomes compared with a healthy omnivorous diet. Clinicians can consider this dietary approach as a healthy alternative for their patients.Trial RegistrationClinicalTrials.gov Identifier: NCT05297825

show abstract

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Alexander

Christopoulos

Davenport

et al. 2019

British J Pharmacology

606

621

View full text Add to dashboard Cite

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (http://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14748. G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

show abstract

Exemplar Abstract for Thiosymbion oneisti (sic) Petersen et al. 2017 and Thiosymbium laxi corrig. Petersen et al. 2017.

Cited by 5 publications

References 1 publication

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Contact Info

Product

Resources

About