Executive Summary of Japanese Domestic Guidelines for Management of Deep-seated Mycosis 2014

Kohno, Shigeru; Tamura, Kazuo; Niki, Yoshihito; Izumikawa, Koichi; Oka, Shinichi; Ogawa, Kenji; Kadota, Jun‐ichi; Kamei, Katsuhiko; Kanda, Yoshinobu; Kiuchi, Tetsuya; Shibuya, Kazutoshi; Takakura, Syunji; Takata, Toru; Takesue, Yoshio; Teruya, Katsuji; Tokimatsu, Issei; Fukuda, Takahiro; Maesaki, Shigefumi; Makimura, Koichi; Mikamo, Hiroshige; Mitsutake, Kotaro; Miyazaki, Yoshitsugu; Mori, Masaaki; Yasuoka, Akira; Yano, Kazuto; Yamanaka, Noboru; Yoshida, Minoru

doi:10.3314/mmj.16-00010

Cited by 34 publications

(54 citation statements)

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“…Acute myeloid leukemia was the most common malignancy, and the onset of mucormycosis frequently occurred during induction therapy. These results are consistent with the fact that cases of induction therapy for acute leukemia are classified as a high-risk group for fungal infections according to the Japanese domestic guidelines for the management of deep-seated mycosis (29). In most cases, the time from the diagnosis to transplantation has been reported to be several months.…”

Section: Discussionsupporting

confidence: 86%

A Radical Approach to Acute Lymphoblastic Leukemia Treatment: A Case Study of a Veterinarian Specializing in Livestock who Developed Disseminated Mucormycosis during Induction Therapy

et al. 2020

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Mucormycosis has emerged as the third-most common fungal mycosis and is one of the most fatal molds. We herein report a case study of a 30-year-old woman who was a veterinarian, specializing in livestock, who developed disseminated mucormycosis during induction therapy for acute lymphoblastic leukemia. We successfully used a radical approach for treatment, including a surgical procedure and allogeneic transplantation, with continuous administration of antifungal agents. Reports of successful treatments are extremely rare, and our case has had the longest documented remission from disseminated disease. We speculate that our case's occupational environment may represent a risk factor for development of mucormycosis.

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Section: Discussionsupporting

confidence: 86%

A Radical Approach to Acute Lymphoblastic Leukemia Treatment: A Case Study of a Veterinarian Specializing in Livestock who Developed Disseminated Mucormycosis during Induction Therapy

et al. 2020

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“…We identified 7230 relevant titles and selected 19 CPGs for inclusion ( Figure 1) (Aguado et al, 2011, Alothman et al, 2014, Bassetti et al, 2013, Bow et al, 2010, Chen et al, 2014, Colombo et al, 2013, Cornely et al, 2012, Elhoufi et al, 2014, JSMM, 2013, Kohno et al, 2016, Kung et al, 2018, Limper et al, 2011, Luo et al, 2014, Montravers et al, 2015, Pappas et al, 2016, Ruhnke et al, 2011, Scudeller et al, 2016, Scudeller et al, 2014, Zaragoza et al, 2014. Table 1 presents the main characteristics of included CPGs.…”

Section: Characteristics Of Selected Guidelinesmentioning

confidence: 99%

“…The single CPG on invasive fungal infection (IFI) in burn patients gave guidance on all three management strategies (targeted, empiric, and prophylaxis). Most (n = 14) CPGs used the GRADE system for grading evidence (Aguado et al, 2011, Alothman et al, 2014, Bassetti et al, 2013, Bow et al, 2010, Colombo et al, 2013, Cornely et al, 2012, JSMM, 2013, Kohno et al, 2016, Kung et al, 2018, Limper et al, 2011, Montravers et al, 2015, Pappas et al, 2016, Ruhnke et al, 2011, Scudeller et al, 2014.…”

Section: Characteristics Of Selected Guidelinesmentioning

confidence: 99%

Antifungal agents for invasive candidiasis in non-neutropenic critically ill adults: What do the guidelines recommend?

Wang

McGuire

Hollingworth

et al. 2019

International Journal of Infectious Diseases

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Objectives: Recommendations in clinical practice guidelines (CPG) may differ and cause confusion. Our objective was to appraise CPGs for antifungal treatment of invasive candidiasis (IC) in non-neutropenic critically ill adult patients. Methods: We systematically searched the literature for CPGs published between 2008 and 2018. We assessed the quality of each guideline using six domains of the AGREE II instrument. We extracted and compared recommendations for different treatment strategies and assessed content quality. Results: Of 19 guidelines, the mean overall AGREE II score was 58%. The domain 'clarity of presentation' received the highest scores (88%) and 'applicability' the lowest (18%). CPGs provided detailed recommendations on antifungal prophylaxis (n = 10), with fluconazole recommended as initial prophylaxis in all seven CPGs citing a specific drug. Echinocandin was recommended as the initial drug in all 16 CPGs supporting empirical/pre-emptive treatment; and in 18 of 19 for targeted invasive candidiasis treatment. However, it remains unclear when to initiate prophylaxis, empirical or preemptive therapy or when to step down. Conclusions: The methodological quality of CPGs for antifungal treatment of IC in non-neutropenic critically ill patients is suboptimal. Some treatment recommendations were inconsistent across indications and require local guidance to help clinicians make better informed decisions.

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“…The filamentous fungi Aspergillus fumigatus is the most common opportunistic human fungal pathogen, with a wide range of clinical features including invasive pulmonary aspergillosis, chronic progressive pulmonary aspergillosis (CPPA), and allergic bronchopulmonary aspergillosis (1). Triazole antifungal drugs are the most common treatment for A. fumigatus infection.…”

Section: Introductionmentioning

confidence: 99%

Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus

Umeyama

Hayashi

Shimosaka

et al. 2018

Preprint

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23Azole resistance in Aspergillus fumigatus is predominantly associated with increased expression 24 of Cyp51A (lanosterol 14α-demethylase), the target enzyme of azole antifungal agents, or with 25 single-nucleotide polymorphisms (SNPs) in cyp51A. Although several SNPs that may be linked 26 to low susceptibility in azole-resistant isolates have previously been reported, few studies have 27 been conducted to conclusively demonstrate the contribution of SNPs to decreased azole 28susceptibility. An A. fumigatus strain was isolated from the sputum of a 74-year-old male 29 receiving long-term voriconazole treatment for chronic progressive pulmonary aspergillosis. 30Etest antifungal susceptibility testing showed low susceptibility to voriconazole, itraconazole, 31 and posaconazole. Nucleotide sequencing of cyp51A from this isolate revealed the mutations 32 Gly138Ser (GGC→AGC) and Asn248Lys (AAT AAA) compared with the cyp51A of 33 azole-susceptible isolates. PCR-amplified DNA fragments containing cyp51A with or without the 34 mutations of interest and a hygromycin marker were simultaneously introduced along with the 35 Cas9 protein and in vitro-synthesized single-guide RNA into protoplasts of the 36 azole-resistant/susceptible strains. Etest azole susceptibility testing of recombinant strains 37 showed an increased susceptibility via the replacement of Ser138 by glycine. In contrast, azole 38 susceptibility was slightly decreased when a Ser138 mutation was introduced into the 39 azole-susceptible strain AfS35, indicating that the serine at position 138 of Cyp51A contributes 40 to low susceptibility in the azole-resistant isolate. Genetic recombination, which has been 41 hampered thus far in clinical isolates, can now be achieved using Cas9/CRISPR genome editing. 42This technique could be useful to investigate the contribution of other SNPs of cyp51A to azole 43 resistance. 44 45

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Executive Summary of Japanese Domestic Guidelines for Management of Deep-seated Mycosis 2014

Cited by 34 publications

References 0 publications

A Radical Approach to Acute Lymphoblastic Leukemia Treatment: A Case Study of a Veterinarian Specializing in Livestock who Developed Disseminated Mucormycosis during Induction Therapy

A Radical Approach to Acute Lymphoblastic Leukemia Treatment: A Case Study of a Veterinarian Specializing in Livestock who Developed Disseminated Mucormycosis during Induction Therapy

Antifungal agents for invasive candidiasis in non-neutropenic critically ill adults: What do the guidelines recommend?

Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus

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