Executive summary: Japanese guidelines for allergic conjunctival diseases 2021

Miyazaki, Dai; Fukushima, Atsuki; Uchio, Eiichi; Shoji, Jun; Namba, Kenichi; Ebihara, Nobuyuki; Takamura, Etsuko; Fukuda, Ken; Matsuda, Akira; Okamoto, Shigeki; Fukagawa, Kazumi; Fujishima, Hiroshi; Ohno, Shigeaki; Ohashi, Yuichi

doi:10.1016/j.alit.2022.07.005

Cited by 17 publications

(15 citation statements)

References 90 publications

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“…The Japanese guideline for ACD [20] de nes the presence of c-Eo as a de nitive diagnosis of ACD if clinical symptoms were observed. C-Eo have been reported to be elevated in atopic conjunctivitis and VKC [39].…”

Section: Discussionmentioning

confidence: 99%

“…[19] The subjects were 110 patients with ACD who visited Yamana Eye Clinic between 2019 and 2021, and consented to the examination. ACD was diagnosed from clinical ocular symptoms of ACD and if those were positive for c-Eo, de nitive diagnosis of ACD was done (20). Classi cation of ACDs was based on the guideline [20].…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…ACD was diagnosed from clinical ocular symptoms of ACD and if those were positive for c-Eo, de nitive diagnosis of ACD was done (20). Classi cation of ACDs was based on the guideline [20]. Ages ranged from 7 to 86 years (mean 55.5 years), with a male to female ratio of 1: 3.…”

Section: Study Design and Participantsmentioning

confidence: 99%

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JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

Yamana,

Uchio

2024

Preprint

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Background: We investigated the relationship between subjective symptoms and objective findings in patients with allergic conjunctival diseases (ACD) and test results for tear total IgE (t-tIgE), conjunctival eosinophils (c-Eo), serum total IgE (s-tIgE), and serum-antigen specific IgE (s-sIgE) serum eosinophils (s-Eo).Methods: Subjective symptoms and objective findings of patients with ACD were evaluated using Japanese Allergic Conjunctival Disease Quality of Life Questionnaire (JACQLQ), which described disability score and emotional score written by patient and clinical findings score written by ophthalmologist. We investigated the relationship between questionnaire scores and laboratory data for t-tIgE, c-Eo, s-tIgE, s-sIgE, and s-Eo.Results: Scores of impediments to life and of moods were highest in vernal keratoconjunctivitis among ACD. Cases with positive pollen-sIgE showed significantly more nasal symptom score than those with negative pollen-sIgE (P < 0.05). Cases with positive t-tIgE or c-Eo showed significantly more objective symptoms’ JACQLQ score than those with negative t-tIgE or c-Eo (P < 0.05), respectively. Cases positive for house dust/mite-sIgE, showed significantly more objective symptoms’ JACQLQ score than those without for house dust/mite-sIgE (P < 0.05).Conclusions: These results indicate that ACD could be analyzed more accurately by the combination of JACQLQ and laboratory data.

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Section: Discussionmentioning

confidence: 99%

Section: Study Design and Participantsmentioning

confidence: 99%

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JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

Yamana,

Uchio

2024

Preprint

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“…These criteria are similarly reported by the European Academy of Allergy and Immunology (EAACI), International Consensus on Ocular Allergy, and Latin American Society of Allergy, Asthma and Immunology (SLAAI) [8,48 ▪ ]. In Japan, VKC is considered a proliferative allergic conjunctival disease with either papillary proliferation of the eyelid conjunctiva, swelling, and bank-like elevation of the limbal conjunctiva, while AKC is defined as a chronic allergic conjunctivitis occurring in patients with AD involving the facial skin with or without proliferative conjunctival changes [49 ▪ ]. Even though some differences in definition exist in different parts of the globe, there is agreement that the clinical diagnosis should be supported by the assessment of the sensitivity to specific allergens by skin prick test and/or serum specific IgE.…”

Section: Diagnostic Criteria: Vernal Keratoconjunctivitis/atopic Kera...mentioning

confidence: 99%

Diagnostic criteria of chronic conjunctivitis: atopic keratoconjunctivitis and vernal keratoconjunctivitis

Leonardi,

Righetti,

Giovannini

et al. 2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewChronic ocular allergies, vernal (VKC) and atopic keratoconjunctivitis (AKC) are relatively rare conditions that require definite diagnostic criteria to the most appropriate therapeutical approach. Recent findingsThe diagnosis of both VKC and AKC is generally based on clinical history, signs and symptoms, and the results of allergic tests, which allow to identify the different diseases phenotypes. However, other subtypes of the two diseases and/or overlaps may occur making the diagnosis non always so clear, such as VKC and AKC overlaps or adult-like VKC disease. Each of these phenotypes may be sustained by different mechanisms which are still not well defined but not only related to a type 2 inflammation. The further challenges will be to correlate clinical or molecular biomarkers to a single subtype or disease severity. SummaryDefinite criteria of chronic allergies will further guide to more specific therapeutical approaches.

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“…The main manifes-tations of children are eye itching and red eye, and burning sensation and tears can occur in severe cases, which have a great impact on the eye health and normal life of patients [1]. The main pathogenesis of AC includes IgE-mediated type I allergy and T-lymphocyte-mediated type IV allergy [2], among which allergic conjunctivitis caused by type I allergy is the most common. At present, the methods of clinical diagnosis of allergic conjunctivitis mainly include history inquiry, clinical manifestations and auxil-iary examinations, among which the auxiliary examinations mainly include cytological examination, allergen stress test and IgE antibody detection [1].…”

Section: Introductionmentioning

confidence: 99%

Clinical study of tear total IgE detection in the diagnosis and treatment of allergic conjunctivitis in children

Guan,

Xu,

Liao

et al. 2024

Preprint

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Objective To provide a new method for the diagnosis of allergic conjunctivitis by detecting the total IgE level of tears in children. Methods 40 patients in our hospital were studied. By measuring and comparing the total IgE level of tears in the experimental group and the control group, the difference between the two groups was compared by statistical methods. Results A total of 40 cases were collected, including 26 cases in the AC exper- imental group and 14 cases in the control group. The total IgE concentration in tears of allergic conjunctivitis patients in the experimental group was mostly lower. There was no significant difference in total IgE level between the control group and the experimental group. Conclusion Tear detection has guiding significance for the diagnosis of AC, but it is difficult to reflect in children. Further studies should be conducted on the basis of this study to make tear detection more accurate and effective for the diagnosis and treatment of allergic conjunctivitis in children.

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Executive summary: Japanese guidelines for allergic conjunctival diseases 2021

Cited by 17 publications

References 90 publications

JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease

Diagnostic criteria of chronic conjunctivitis: atopic keratoconjunctivitis and vernal keratoconjunctivitis

Clinical study of tear total IgE detection in the diagnosis and treatment of allergic conjunctivitis in children

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