Executive summary: Consensus document of the diagnosis, management and prevention of infection with the hepatitis E virus: Study Group for Viral Hepatitis (GEHEP) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)

Rivero‐Juárez, Antonio; Aguilera, Antonio; Avellón, Ana; García-Deltoro, Miguel; García, Féderico; Gortázar, Christian; Granados, Rafael; Macı́as, Juan; Merchante, Nicolás; Oteo, José Antonio; Pérez‐Gracia, María Teresa; Pineda, Juan A; Rivero, Antonio; Rodrı́guez-Lázaro, David; Téllez, Francisco Ayuga; Morano-Amado, Luis E.

doi:10.1016/j.eimce.2018.06.014

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…La resolución de las pruebas bioquímicas anormales generalmente ocurre dentro de 1-6 semanas después del inicio de la enfermedad (26). Los marcadores virológicos para el diagnóstico de la infección por VHE comprenden el ácido ribonucleico (VHE-RNA), el antígeno viral (VHE-Ag) y los anticuerpos específicos anti-VHE de clases IgA, IgG e IgM (27). Éstos son la base no solo para el diagnóstico sino también para el seguimiento del tratamiento, permiten caracterizar la historia natural de la hepatitis E en sus diferentes fases: aguda, reciente, resuelta o pasada y crónica (Ver figura 2) (1,11).…”

Section: Diagnósticounclassified

“…Se recomienda la tamización para infección por VHE a niños inmunocompetentes que presenten aumento de las aminotransferasas o manifestaciones extrahepáticas, y adicionalmente en los pacientes inmunosuprimidos, a aquellos que cursen con hepatitis aguda, enfermedad hepática de causa desconocida, inducida por fármacos o que desarrollen IHA. También deben incluirse pacientes con enfermedad hepática crónica conocida o recientemente diagnosticada con descompensación y/o agudización y todo donante de sangre u órgano sólido vivo o fallecido (17,27,28). Figura 2.…”

Section: Tamizaciónunclassified

“…Se recomienda un seguimiento de los pacientes inmunocompetentes con infección aguda por VHE durante 12 semanas para determinar el estado del ARN del VHE al final de este período. Los pacientes con infección aguda por VHE con evidencia clínica de insuficiencia hepática sean ingresados en una unidad de cuidados intensivos para iniciar el tratamiento por VHE (27).…”

Section: Seguimiento De La Infección Agudaunclassified

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Hepatitis E, una amenaza en la población pediátrica vulnerable

Correa-Pérez,

Losada-Gómez,

Wilches-Luna

2023

Pediatria.

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Introducción: La hepatitis E constituye un importante problema de salud pública. Es un virus emergente a nivel global que no sólo tiene presentación aguda autolimitada, también puede llegar a generar insuficiencia hepática fulminante y falla hepática crónica. Los niños son la población más vulnerable con respecto a los virus de transmisión fecal-oral. Actualmente, es infradiagnosticada por la falta de disponibilidad oportuna a las pruebas. Objetivo: Revisión de la literatura y actualizar conceptos en epidemiología, métodos de transmisión, manifestaciones clínicas, complicaciones y formas de prevención. Métodos: Se revisaron las bases de datos de bases de datos como Medline, Pubmed, Clinical Key, Science direct y Embase, Resultados: se incluyeron artículos de actualización de tema con recomendaciones basadas en niveles de evidencia. Conclusiones: Se debe concientizar a los profesionales de la salud, para sospechar el diagnóstico de hepatitis E, hacer seguimiento clínico, hacer tratamiento de soporte y fomentar las medidas de prevención a nivel individual y comunitario.

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Section: Diagnósticounclassified

Section: Tamizaciónunclassified

Section: Seguimiento De La Infección Agudaunclassified

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Hepatitis E, una amenaza en la población pediátrica vulnerable

Correa-Pérez,

Losada-Gómez,

Wilches-Luna

2023

Pediatria.

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Presence of hepatitis E virus in testis of naturally infected wild boars

Risalde

Frías

Caballero‐Gómez

et al. 2022

Transbounding Emerging Dis

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The hepatitis E virus (HEV) is the main cause of viral acute hepatitis in the world, affecting more than 20 million people annually. During the acute phase of infection, HEV can be detected in various body fluids, which has a significant impact in terms of transmission, diagnosis or extrahepatic manifestations. Several studies have isolated HEV in the genitourinary tract of humans and animals, which could have important clinical and epidemiological implications. So, our main objective was to evaluate the presence of HEV in testis of naturally infected wild boars (Sus scrofa). For it, blood, liver, hepatic lymph node and testicle samples were collected from 191 male wild boars. The presence of HEV was evaluated in serum by PCR, as well as in tissues by PCR and immunohistochemistry. Four animals (2.09%; 95%CI: 0.82-5.26) showed detectable HEV RNA in serum, being confirmed the presence of HEV-3f genotype in three of them by phylogenetic analysis. HEV was also detected in liver and/or hepatic lymph nodes of the four animals by RT-PCR, as well as by immunohistochemistry analysis. Only one of these wild boars also showed detectable viral load in testis, observing HEV-specific labelling in a small number of fibroblasts and some Sertoli cells. Our results confirm the This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Hepatitis E virus and Zoonosis: Recent Advances and Therapeutic Implications

Hon

Leung

Wong

et al. 2023

RAIAD

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Background: Hepatitis E is viral hepatitis caused by infection with the hepatitis E virus (HEV). Objective: This article aims to review HEV disease and recent advances in the management of hepatitis E. Methods: We used PubMed Clinical Queries and keywords of “hepatitis E”, “hepatitis E virus” AND “zoonosis” as the search engine. “Therapy”, “Clinical Prediction Guides”, “Diagnosis”, “Etiology” and “Prognosis” were used as filters, and “Narrow” scope was used. The search was conducted in April 2022. The information retrieved from the above search was used in the compilation of the present article. Results: Hepatitis E is viral hepatitis caused by infection with the hepatitis E virus (HEV). Hepatitis E has mainly a fecal-oral transmission route. Hepatitis E infection usually follows an acute and self-limiting course of illness with low death rates in resource-rich areas; however, it can be more severe in pregnant women and immunocompromised people. The mortality rates in these groups are substantially higher. A vaccine for HEV is available but is not universally approved. Ribavirin remains the most efficacious medication for the treatment of HEV but is contraindicated in pregnancy. Sofosbuvir and pegylated interferon, with or without ribavirin, have not been shown in the latest literature reviews to provide reliable additional benefits to the treatment of hepatitis. Sofosbuvir should not be used as monotherapy for HEV. Food is an important source of infection in many countries while rats are the primary vector in developing nations. Management must include an understanding of the rat habitats for this zoonotic disease. Conclusions: Hepatitis E remains an important cause of hepatitis and a zoonotic disease globally. Public health policies are key to containing this viral infectious disease, including policy in the transfusion of blood products.

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Executive summary: Consensus document of the diagnosis, management and prevention of infection with the hepatitis E virus: Study Group for Viral Hepatitis (GEHEP) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)

Cited by 3 publications

References 7 publications

Hepatitis E, una amenaza en la población pediátrica vulnerable

Hepatitis E, una amenaza en la población pediátrica vulnerable

Presence of hepatitis E virus in testis of naturally infected wild boars

Hepatitis E virus and Zoonosis: Recent Advances and Therapeutic Implications

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