Executive Functions Development in 5- to 7-Year-Old Children With Transposition of the Great Arteries: A Longitudinal Study

Calderon, Johanna; Jambaqué, Isabelle; Bonnet, Damien; Angeard, Nathalie

doi:10.1080/87565641.2014.916709

Cited by 52 publications

(58 citation statements)

References 39 publications

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“…Although processing speed is understudied in this population, it appears that vulnerabilties in this domain could underlie poor performance in some tasks of executive function as suggested in a previous study (Calderon et al, 2014). Findings regarding attention problems expand upon previous studies by utilizing both patient- and parent-reported symptoms as well as using clinically relevant measures (Calderon et al, 2010; McCusker, Armstrong, Mullen, Doherty, & Casey, 2013).…”

Section: Discussionmentioning

confidence: 67%

“…Recent studies of children with d-TGA and TOF have found effects in several areas of cognitive function including attention and inhibition (Bellinger, Wypij, Rappaport, Jonas, Wernovsky, & Newburger, 2003; Calderon, Bonnet, Courtin, Concordet, Plumet, & Angeard, 2010; Miatton, De Wolf, François, Thiery, & Vingerhoets, 2007; Shillingford, Glanzman, Ittenbach, Clancy, Gaynor, & Wernovsky, 2008), working memory (Calderon et al, 2010), and visual-spatial processing (Bellinger et al, 2003, 2011). A recent study by Calderon, Jambaqué, Bonnet, and Angeard, (2014) examining the emergence of executive dysfunction in children with d-TGA found significant delays in the areas of inhibition and cognitive flexibility and suggested that deficits in processing speed may underlie these delays. Taken together, there is evidence that children with CHD are at risk for deficits or relative weaknesses in the multiple domains of cognitive function, but this has been studied less frequently during the period of adolescence and young adulthood (see Bellinger & Newburger, 2011 for exception).…”

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confidence: 99%

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Cognitive and attentional functioning in adolescents and young adults with Tetralogy of Fallot and d-transposition of the great arteries

Murphy

Compas

Reeslund

et al. 2015

Child Neuropsychology

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Objectives To investigate cognitive and attentional function in adolescents and young adults with operated congenital heart disease. Background Previous research has indicated that children with congenital heart disease have deficits in broad areas of cognitive function. However, less attention has been given to survivors as they grow into adolescence and early adulthood. Method Participants included 18 non-syndromic adolescents and young adults with Tetralogy of Fallot and d-Transposition of the Great Arteries that required cardiac surgery before the age of five and 18 healthy, unaffected siblings (age 11–22 years for both groups). Cases with congenital heart disease and their siblings were administered Wechsler Intelligence scales and reported attention problems using the Achenbach System of Empirically Based Assessments. Cases were compared to both healthy siblings and established norms. Key Findings Cases performed significantly lower than siblings on Full Scale IQ and processing speed, and significantly lower than norms on perceptual reasoning. Cases also reported more attention problems compared to both siblings and norms. Effect sizes varied with medium to large effects for processing speed, perceptual reasoning, working memory, and attention problems. Conclusions Findings suggest that neurocognitive function may continue to be affected for congenital heart disease survivors in adolescence and young adulthood and that comparisons to established norms may underestimate neurocognitive vulnerabilities.

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Section: Discussionmentioning

confidence: 67%

mentioning

confidence: 99%

Cognitive and attentional functioning in adolescents and young adults with Tetralogy of Fallot and d-transposition of the great arteries

Murphy

Compas

Reeslund

et al. 2015

Child Neuropsychology

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“…2 While advances in medical care have reduced surgical mortality and morbidity for children with critical CHD, their survival has exposed neurodevelopmental and psychiatric morbidities. 3–12 These children display deficits in visual-perceptive skills, 4–5,13 executive function, 4–5,9–11 attention deficit hyperactivity disorder (ADHD) symptoms, 8,14 and reduced quality of life. 15–16 In contrast, few data are available on mental health outcomes of critical CHD survivors in adolescence.…”

Section: Introductionmentioning

confidence: 99%

Psychiatric Disorders in Adolescents With Single Ventricle Congenital Heart Disease

DeMaso¹,

Calderon²,

Taylor³

et al. 2017

Pediatrics

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157

124

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Background and Objectives Mental health outcomes for survivors of critical congenital heart disease (CHD) remain under-investigated. We sought to examine psychiatric disorders and psychosocial functioning in adolescents with single ventricle CHD and to explore whether patient-related risk factors predict dysfunction. Methods This cohort study recruited 156 adolescents with single ventricle CHD who underwent the Fontan procedure and 111 healthy referents. Participants underwent comprehensive psychiatric evaluation including a clinician-rated psychiatric interview and parent- and self-report ratings of anxiety, disruptive behavior – including attention deficit hyperactivity disorder (ADHD), and depressive symptoms. Risk factors for dysfunction included IQ, medical characteristics, and concurrent brain abnormalities. Results Adolescents with single ventricle CHD had higher rates of lifetime psychiatric diagnosis compared with referents (CHD: 65%, referent: 22%; P<0.001). Specifically, they had higher rates of lifetime anxiety disorder and ADHD diagnosis (P<0.001 each). The CHD group scored lower on the primary psychosocial functioning measure, the Children’s Global Assessment Scale (CGAS), than referents (CHD median [interquartile range]: 62 [54–66], referent: 85 [73–90]; P<0.001). The CHD group scored worse on measures of anxiety, disruptive behavior, and depressive symptoms. Genetic comorbidity did not impact most psychiatric outcomes. Risk factors for anxiety disorder, ADHD, and lower CGAS scores included lower birth weight, longer duration of deep hypothermic circulatory arrest, lower intellectual functioning, and male gender. Conclusions Adolescents with single ventricle CHD display a strikingly high risk of psychiatric morbidity, particularly anxiety disorders and ADHD. Early identification of psychiatric symptoms is a key component of the management of patients with CHD.

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“…Impairments were evident on both verbal and non-verbal tasks, with children tending to focus on isolated details at the expense of a coherent organization of elements (13, 23). Calderon et al (24, 25) corroborated these findings in two cohorts of 5- and 7-year olds with d -TGA. In these studies, children had difficulties elaborating a strategy to achieve a goal, i.e., anticipating the right number of actions to reproduce a visual model.…”

Section: Neuropsychological Outcomes In Children With D-tgamentioning

confidence: 70%

“…Executive functioning issues start early in preschool years. Calderon et al (25) demonstrated that executive function impairments were common at the age of 5, in tasks measuring behavioral control, attention, working memory, and cognitive flexibility. Executive function deficits were also reported in children with other types of complex CHD (26, 27), suggesting that they are part of the “developmental signature” of critical CHD.…”

Section: Neuropsychological Outcomes In Children With D-tgamentioning

confidence: 99%

Neuropsychological and Psychiatric Outcomes in Dextro-Transposition of the Great Arteries across the Lifespan: A State-of-the-Art Review

et al. 2017

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Advances in prenatal diagnosis, perioperative management, and postoperative care have dramatically increased the population of survivors of neonatal and infant heart surgery. The high survival rate of these patients into adulthood has exposed the alarming prevalence of long-term neuropsychological and psychiatric morbidities. Dextro-transposition of the great arteries (d-TGA) is one of the most extensively studied cyanotic congenital heart defect (CHD) with regard to neurodevelopmental outcomes. Landmark studies have described a common neurodevelopmental and behavioral phenotype associated with d-TGA. Children with d-TGA display impairments in key neurocognitive areas, including visual–spatial and fine motor abilities, executive functioning, processing speed, and social cognition. As they grow older, they may face additional challenges with a worsening of deficits in higher order cognitive skills, problems in psychosocial adjustment and a higher-than-expected rate of psychiatric disorders, such as attention-deficit hyperactivity disorder, depression, and anxiety. The aim of this review is to summarize the available recent data on neuropsychological and psychiatric outcomes in individuals with d-TGA after the arterial switch operation. We present findings within a life-span perspective, with a particular emphasis on the emerging literature on adolescent and young adult outcomes. Finally, we propose avenues for future research in the CHD adult neuropsychology field. Among these avenues, we explore the potential mechanisms by which pediatric neurodevelopmental impairments may have lifelong adverse effects as well as alternative interventions that could optimize outcomes.

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Executive Functions Development in 5- to 7-Year-Old Children With Transposition of the Great Arteries: A Longitudinal Study

Cited by 52 publications

References 39 publications

Cognitive and attentional functioning in adolescents and young adults with Tetralogy of Fallot and d-transposition of the great arteries

Cognitive and attentional functioning in adolescents and young adults with Tetralogy of Fallot and d-transposition of the great arteries

Psychiatric Disorders in Adolescents With Single Ventricle Congenital Heart Disease

Neuropsychological and Psychiatric Outcomes in Dextro-Transposition of the Great Arteries across the Lifespan: A State-of-the-Art Review

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