Executive Control Mediates Memory's Association with Change in Instrumental Activities of Daily Living: The Freedom House Study

Royall, Donald R.; Palmer, Raymond F.; Chiodo, Laura K.; Polk, Marsha J.

doi:10.1111/j.1532-5415.2005.53004.x

Cited by 138 publications

(119 citation statements)

References 37 publications

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“…If so, failing executive abilities would then reduce compensatory ability and compound the loss of everyday function. Consistent with the present data, Royall and colleagues (Royall et al, 2005) found that change in executive function, but not change in memory, was associated with change in functional impairment over time, also suggesting that executive dysfunction may be particularly important to longitudinal declines in everyday function.…”

Section: Discussionsupporting

confidence: 90%

“…First, executive dysfunction may play a particularly important role in the progression of disability. For example, Royall (Royall, 2006;Royall et al, 2004, Royall et al,2005 argues for the central role of executive dysfunction in causing functional disability and in the conversion of MCI to dementia. Perhaps executive functions, because of their role in regulating and coordinating other mental functions, organizing behavior and generating responses, play a central role in a variety of everyday activities.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive and neuroimaging predictors of instrumental activities of daily living

Cahn-Weiner

Farias

Julián

et al. 2007

J. Inter. Neuropsych. Soc.

187

167

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Impaired ability to conduct daily activities is a diagnostic criterion for dementia and a determinant of healthcare services utilization and caregiver burden. What predicts decline in instrumental activities of daily living (IADLs) is not well understood. This study examined measures of episodic memory, executive function, and MRI brain volumes in relation to baseline IADLs and as predictors of rate of IADL change. Participants were 124 elderly persons with cognitive function between normal and moderate dementia both with and without significant small vessel cerebrovascular disease. Random effects modeling showed that baseline memory and executive function (EXEC) were associated with baseline IADL scores, but only EXEC was independently associated with rate of change in IADLs. Whereas hippocampal and cortical gray matter volumes were significantly associated with baseline IADL scores, only hippocampal volume was associated with IADL change. In a model including cognitive and neuroimaging predictors, only EXEC independently predicted rate of decline in IADL scores. These findings indicate that greater executive dysfunction at initial assessment is associated with more rapid decline in IADLs. Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Cognitive and neuroimaging predictors of instrumental activities of daily living

Cahn-Weiner

Farias

Julián

et al. 2007

J. Inter. Neuropsych. Soc.

187

167

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated the importance of executive function in the performance of IADL [16,31,32]. In our study, TMT-B was correlated with IADL and the 3 executive subscales.…”

Section: Discussionsupporting

confidence: 67%

Functional Disability Profiles in Amnestic Mild Cognitive Impairment

Yeh

Lin

Chen³

et al. 2011

Dement Geriatr Cogn Disord

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Background/Aims: Instrumental activities of daily living (IADL) can be impaired in mild cognitive impairment (MCI), and the severity of functional disability predicts Alzheimer’s disease (AD) in amnestic MCI (aMCI). This study investigated the functional profiles of aMCI in a Chinese population. Methods: The Disability Assessment for Dementia scores of 56 subjects with single-domain aMCI (sd-aMCI) and 94 with multiple-domain aMCI (md-aMCI) were compared with normal controls (n = 64) and mild AD patients (n = 102). Results: Both the sd-aMCI (2.5 ± 2.5) and md-aMCI (3.7 ± 3.5) groups had more impaired IADL items than the controls (0.7 ± 1.7). Their IADL scores were intermediate, between the control and AD groups. sd-aMCI subjects presented deficits in 7 IADL items involving the ‘meal preparation’, ‘telephoning’, ‘finance’, ‘medications’, ‘housework’, and ‘leisure’ subscales. md-aMCI subjects presented deficits in 14 IADL items involving all subscales of daily activities. The Mini-Mental State Examination and Modified Trail-Making Test Part B scores were the major neuropsychological correlates of IADL performance in aMCI. Conclusion: IADL can be impaired in both sd-aMCI and md-aMCI. Including the functional ability assessment in the evaluation of aMCI may help clinicians to provide appropriate suggestions to maintain daily functioning.

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“…Se ha descrito que el deterioro cognoscitivo con cambios en el control de las funciones ejecutivas es suficiente para explicar el deterioro funcional general, y que las personas con deterioro cognoscitivo amnésico tienen menor riesgo de llegar a la demencia que las que presentan problemas en el control de funciones ejecutivas (46,47). En un estudio realizado por Royall y colaboradores se describe que los cambios en el control de las funciones ejecutivas están relacionadas con las actividades instrumentales de la vida diaria y, por lo tanto, con el deterioro de la capacidad funcional (48).…”

Section: Cuadro 2 Estado De Salud De Los Adultos Mayores Estudiadosunclassified

Determinantes del riesgo de desnutrición en los adultos mayores de la comunidad: análisis secundario del estudio Salud, Bienestar y Envejecimiento (SABE) en México

Franco-Álvarez¹,

Ávila-Fuñes²,

Ruiz-Arregui³

et al. 2007

Rev Panam Salud Publica

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Objetivo. Determinar los factores psicosociales y de salud asociados con el riesgo de desnutrición (RD) en los adultos mayores que viven en la comunidad en la Ciudad de (OR ajustada = 5,41; IC95%: 1,90 a 15,34), el hacer sólo una (OR ajustada = 12,95; IC95%: 5,19 a 32,28) o dos comidas al día (OR ajustada = 3,27; IC95%: 2,18 a 4,9) y el tener dificultades para acostarse solo (OR ajustada = 3,25; IC95%: 1,58 a 6,68), salir solo (OR ajustada = 2,70; IC95%: 1,54 a 4,73)

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Executive Control Mediates Memory's Association with Change in Instrumental Activities of Daily Living: The Freedom House Study

Cited by 138 publications

References 37 publications

Cognitive and neuroimaging predictors of instrumental activities of daily living

Cognitive and neuroimaging predictors of instrumental activities of daily living

Functional Disability Profiles in Amnestic Mild Cognitive Impairment

Determinantes del riesgo de desnutrición en los adultos mayores de la comunidad: análisis secundario del estudio Salud, Bienestar y Envejecimiento (SABE) en México

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