Excretion pattern of co-planar and non-planar tetra- and hexa-chlorobiphenyls in ovine milk and faeces

Vrecl, Milka; Uršič, Matjaž; Pogačnik, A.; Zupančič‐Kralj, Lucija; Jan, Janja

doi:10.1016/j.taap.2004.08.017

Cited by 16 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding can be explained by dose-related induction of CYPs involved in PBDE metabolism already reported in rodents [23] . As already reported in ovine models [25] , we detected the background level of PCB in all sheep. On the contrary, no trace of three PBDE congeners was detected in the control group.…”

Section: Discussionsupporting

confidence: 87%

Thyroid Disruption by Low-Dose BDE-47 in Prenatally Exposed Lambs

Abdelouahab¹,

Suvorov²,

Pasquier³

et al. 2009

Neonatology

View full text Add to dashboard Cite

The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 μg/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T₄ and T₃ in exposed lambs without any effect in pregnant sheep. Our finding indicates that prenatal low-dose PBDE exposure results in PBDE storage in fat of offspring and can affect thyroid metabolism in the developing fetus.

show abstract

Section: Discussionsupporting

confidence: 87%

Thyroid Disruption by Low-Dose BDE-47 in Prenatally Exposed Lambs

Abdelouahab¹,

Suvorov²,

Pasquier³

et al. 2009

Neonatology

View full text Add to dashboard Cite

show abstract

“…The dose for PCB‐169 was based on its TEF (0.03; Van den Berg et al, ) and on the corresponding concentration of toxic equivalents (TEQs), which is an estimate of the total TCDD‐like activity. To achieve comparable and constant levels of both PCBs throughout the exposure period, administration regimes with loading and maintenance doses were used; these regimes were based on PCB‐155 and PCB‐169 excretion patterns in ovine milk (Vrecl et al, ). The first group (PCB‐155; n = 4) was administered PCB‐155.…”

Section: Methodsmentioning

confidence: 99%

“…The selected PCB congeners, PCB‐155 (2,2',4,4',6,6'‐hexachlorobiphenyl) and PCB‐169 (3,3',4,4',5,5'‐hexachlorobiphenyl), differ in the position of their chlorine atoms and, consequently, in their planarity and presumed toxicity. The dioxin‐like PCB‐169, with an assigned TEF of 0.03 (Van den Berg et al, ), is more lipophilic, metabolically stable and potentially more toxic to the suckling offspring due to its higher excretion in milk relative to PCB‐155 (Vrecl et al, ). The estrogen receptor affinity of non‐planar PCBs, including PCB‐155, could mimic the effects of the endogenous ligand, and these PCBs have low acute toxicity (Van der Burght et al, ).…”

Section: Introductionmentioning

confidence: 99%

Alterations in geometry, biomechanics, and mineral composition of juvenile rat femur induced by nonplanar PCB‐155 and/or planar PCB‐169

Brankovič

Jovanovski

Jevnikar

et al. 2016

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

Exposure to widespread lipophilic and bioaccumulative polychlorinated biphenyls (PCBs) induces diverse biochemical and toxicological responses in various organs, including the bone. The aim of this study was to evaluate the changes in growth rate, geometry, serum, and bone biochemical parameters and biomechanics of juvenile rat femur induced by lactational exposure to nonplanar PCB-155 and planar PCB-169 individually and in combination. Fifteen lactating Wistar rats were divided into four groups (PCB-169, PCB-155, PCB-155+169, and control), and PCBs were administered intraperitoneally at different time points after delivery. Femurs from 22-day-old offspring were analyzed by microCT, three-point bending test and inductively coupled plasma-mass spectrometry (ICP-MS) to obtain data on bone geometry, biomechanics and mineral composition. The serum levels of calcium, phosphate and alkaline phosphatase were also determined. Lactational exposure to planar PCB-169 resulted in shorter and thinner femurs, reduced endosteal and periosteal perimeters, smaller total cross-sectional and medullary areas, and lowered serum bone marker levels and calcium levels in the bone, while femur mechanical properties were not significantly altered. The changes observed in the combination exposure (PCB-155+169) group were similar to those observed in the PCB-169 group but were less pronounced. In summary, our results demonstrate that alterations in lactationally exposed offspring were primarily induced by planar PCB-169. The milder outcome in the combined group suggested that the PCB-169-mediated toxic effects on the bone might be reduced by a nonplanar PCB-155 congener. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1135-1146, 2017.

show abstract

“…The concentration of PCB 118 in milk is lower than in blood (Table 6), according to Thomas et al (1999c), which can be explained by the fact that the congeners contained in blood are not necessarily totally amenable to being incorporated in tissues, perhaps because they are associated with haematic components, which could explain the discrepancy (Vrecl et al, 2005).…”

Section: Pcbs In Milkmentioning

confidence: 95%

Monitoring of the declining trend of Polychlorobifenyls concentration in milk of contaminated dairy cows

Rossi

Bertuzzi

Vitali

et al. 2010

Italian Journal of Animal Science

View full text Add to dashboard Cite

Six pregnant heifers, coming from a herd with a history of high concentration of polychlorobifenyls (PCB) into the milk, were fed with a very low-PCB diet starting from the 6th month of pregnancy. After parturition cows were milked for at least 190 d with a maximum of 270 d. Diet was made of: corn silage (31.7% of DMI), dehydrated alfalfa (13.3% of DMI), grass hay (3.7% of DMI) and concentrate (51.3% of DMI). The average DMI was 23.12 kg/d. Milk production was recorded and samples of milk and blood were taken and analyzed for PCB (18, 28, 31, 52, 44, 101, 149, 118, 153, 138, 180 and 194 congeners) content using a GC-MS technique. The average milk yield (kg/d) of the 6 cows was 26.0, 22.5, 23.2, 24.5, 28.9, 29.3. The maximum PCB concentration of 100 ng/g of fat allowed by the Italian law was reached after 144-209 d of lactation. One animal after 204 days had a PCB concentration of 102 ng/g fat. If log10 of PCB concentration (ppb) in milk fat is regressed against days in milking (DIM) the following significant equation was obtained: log10 PCB (ng/g of milk fat)= 2.796 -0.00474 DIM; r2 0.72; P<0.01 The initial level of contamination is not the main factor affecting the time required in order for PCB to return to below the legal threshold of 100 ng/g fat, while daily milk yield significantly affects PCB excretion. Body condition and energy balance could be important factors affecting PCB excretion. In the presence of high contamination, about 6 months of lactation are required in order to obtain milk with a sufficiently low PCB content. Among the seven congeners considered by Italian legislation, PCB 101, PCB 118, PCB 138, PCB 153 constitute almost all the PCBs found in tissues and milk, with a much smaller presence of PCB 180, and the numbers of the congeners PCB 28 and PCB 52 are almost insignificant, probably because they accumulate little in the body. The congeners PCB 138 and PCB 153 are those most frequently found. For PCB 138 the liver is the principal organ of accumulation, while for PCB 153 we found equal accumulations in the liver, kidneys and tail, but a low presence in milk. The PCBs 118 and 138 are those most abundant in milks

show abstract

Excretion pattern of co-planar and non-planar tetra- and hexa-chlorobiphenyls in ovine milk and faeces

Cited by 16 publications

References 24 publications

Thyroid Disruption by Low-Dose BDE-47 in Prenatally Exposed Lambs

Thyroid Disruption by Low-Dose BDE-47 in Prenatally Exposed Lambs

Alterations in geometry, biomechanics, and mineral composition of juvenile rat femur induced by nonplanar PCB‐155 and/or planar PCB‐169

Monitoring of the declining trend of Polychlorobifenyls concentration in milk of contaminated dairy cows

Contact Info

Product

Resources

About