Excretion of Steroid Hormones in Rodents: An Overview on Species Differences for New Biomedical Animal Research Models

Busso, Juan Manuel; Ruiz, Rubén Daniel

doi:10.5772/17051

Cited by 5 publications

(6 citation statements)

References 88 publications

(126 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This creates two issues for the interpretation of concentrations. First, clearance rates for steroids differ depending upon the biological sample, in the order of minutes in saliva, minutes-to-hours in urine and hours-to-days in faeces [33]. Quantifying the clearance rates of labelled steroids can clarify these temporal issues.…”

Section: Lemurs (Lemur Spp)mentioning

confidence: 99%

The influence of androgenic steroid hormones on female aggression in ‘atypical’ mammals

French

Mustoe

Cavanaugh

et al. 2013

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Dimorphism on dominance and agonistic behaviour in mammals tends to be strongly biased toward males. In this review, we focus on a select few species of mammals in which females are as or more aggressive than males, and/or are dominant to males, and explore the role of androgenic hormones in mediating this important difference. While the data are not as clear-cut as those published on traditional laboratory mammals, our review highlights important endocrine substrates for both organizational and activational influences of steroids on female aggressive behaviour. We highlight areas in which further observations and experiments are crucial, especially the potential facilitative effects of androgens on female aggression. Finally, new and innovative techniques, including molecular genetics and receptor pharmacology, portend important insights into the ways in which androgenic hormones regulate aggressive behaviour in 'atypical' female mammals.

show abstract

Section: Lemurs (Lemur Spp)mentioning

confidence: 99%

The influence of androgenic steroid hormones on female aggression in ‘atypical’ mammals

French

Mustoe

Cavanaugh

et al. 2013

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

show abstract

“…However, it is important to note that FGM measurements taken at recapture in our study were likely not representative of the GSNRs' maximal responses. Repeated sampling over several days after a known stress event would have enabled us to make inferences about peak FGM levels and estimate the species' excretion lag time [ 23 , 53 ], but these short-term stress indicators were unnecessary for our longer-term study goals. Some GSNRs displayed minimal change in FGMs at recapture, indicating they did not find capture as disruptive as other individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, blood sampling gives a snapshot of glucocorticoid levels at the specific time of sampling, while faecal samples contain average levels of hormone metabolites and provide information about the animal's experience over a period of time, dependent on defecation rates [ 22 ]. However, when the body metabolizes glucocorticoids they are broken into numerous metabolite structures and excreted, and every species, even those closely related, has a unique metabolism [ 23 ]. Therefore, the method being used to quantify the faecal metabolites must be validated to ensure that it is accurately measuring metabolites of the hormone of interest [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Physiological response after translocation differs between source populations in a threatened mammal

Williams-Kelly,

Berry,

Branch

et al. 2023

R. Soc. open sci.

View full text Add to dashboard Cite

Conservation translocations are an important tool in the prevention of species loss, but the translocation process is associated with numerous stressors. Non-invasively monitoring stress physiology via faecal glucocorticoid metabolites (FGMs) can provide valuable insights into factors impacting translocation success and how to mitigate negative impacts. After validating an assay to measure FGMs in greater stick-nest rats ( Leporillus conditor ), we examined whether translocation caused a predictable change in physiology. We compared longer-term (one to five months post-translocation) physiological responses across three source populations (remnant-wild, reintroduced-wild, captive-bred), and investigated effects of body condition and sex on FGMs. Notably, FGMs of the remnant-wild population did not significantly change post-translocation, while the reintroduced-wild population exhibited a significant decrease and the captive-bred population a significant increase. Individuals in lower body condition had the highest FGMs in both wild-type populations, whereas the captive-bred population showed the opposite relationship. There was no difference in FGMs between the sexes. Our work highlights that physiological responses after translocation may not be uniform and source population history is an important factor to be considered, emphasizing the need for novel ideas that facilitate successful adaptation. By better understanding how species and individuals respond to translocation, we can improve translocation outcomes.

show abstract

“…En especies protegidas e indexadas en CITES como es el caso de L. gigas, su colecta y más aún su sacrificio, requieren la obtención de permisos. Por lo anterior, una alternativa para el estudio de hormonas son los métodos no invasivos, a través de las excretas (Busso & Ruiz, 2011;Sheriff, Dantzer, Delehanty, Palme, & Boonstra, 2011).…”

Section: Discussionunclassified

Cuantificación de hormonas 17β - estradiol y progesterona en el caracol rosa Lobatus gigas (Mollusca, Gastropoda)

Sánchez

Díaz

Aranda

2019

RBT

View full text Add to dashboard Cite

Las hormonas sexuales son responsables del mantenimiento de los caracteres sexuales, maduración de gametos y del comportamiento sexual en vertebrados y algunos invertebrados. Lobatus gigas es un gasterópodo de importancia económica y ecológica del Caribe, para el cual pocos han sido los estudios de su reproducción en cautiverio y de la influencia de hormonas en el proceso. El objetivo de este trabajo fue determinar la presencia de estrógeno y progesterona en L. gigas y comparar las concentraciones de estas hormonas con la técnica de cromatografía liquida de alta resolución y la de Enzimoinmunoensayo. Ambas técnicas arrojaron resultados similares principalmente al medir estrógeno, sin embargo, las diferencias entre éstas no permite que sean utilizadas de manera indistinta. Junto con estos resultados, el análisis de sus costos, requerimientos de personal y de instrumentos, se concluye que la técnica de Enzimoinmunoensayo es la más viable para continuar con los estudios sobre hormonas en L. gigas. El conocimiento de la posible acción que llevan a cabo las hormonas estrógeno y progesterona en el proceso reproductivo de esta especie permitiría comprender y manejar aspectos reproductivos fundamentales para el mejoramiento del cualquier cultivo de reproductores del caracol rosa.

show abstract

Excretion of Steroid Hormones in Rodents: An Overview on Species Differences for New Biomedical Animal Research Models

Cited by 5 publications

References 88 publications

The influence of androgenic steroid hormones on female aggression in ‘atypical’ mammals

The influence of androgenic steroid hormones on female aggression in ‘atypical’ mammals

Physiological response after translocation differs between source populations in a threatened mammal

Cuantificación de hormonas 17β - estradiol y progesterona en el caracol rosa Lobatus gigas (Mollusca, Gastropoda)

Contact Info

Product

Resources

About