Excretion of <i>Ascaris lumbricoides</i> following reduced‐intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole

Luber, V.; Lutz, Mathias; Abele‐Horn, Marianne; Einsele, Hermann; Grigoleit, Götz Ulrich; Mielke, Stephan

doi:10.1111/tid.13224

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Several parasitic molecules have been implicated in modulating the immune and allergic response of helminth-infected hosts [ 27 ]. It has been described that parasite infections can develop a strong response and high levels of IgE in allergic sufferers, i.e., asthma or tropical pulmonary eosinophilia [ 28 , 29 , 30 , 31 ]. Moreover, it seems that infections by A. lumbricoides, T. canis, T. trichiura , hookworm, and S. mansoni can cause allergic reactions in humans [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Montoya-Alonso

Morchón

Matos

et al. 2020

Animals

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The Canary Islands are hyperendemic for canine heartworm and the risk of zoonotic infection is high. Additionally, there is evidence of development of allergies due to nematode infections in animals and humans. Since the population of the Canary Islands presents high prevalence of allergic comorbidities, and previous studies have shown a possible relationship between allergies and seropositivity to heartworm, the aim was to evaluate whether exposure to heartworm may contribute to the development of allergies in the human population. First, an epidemiological study was conducted on 248 owners of dogs with/without heartworm infection in the Canary Islands. Secondly, a serological analysis of the presence of total IgE and specific IgE against heartworm was conducted in 66 samples of inhabitants of the Canary Islands. The survey showed that allergic owners had heartworm-positive dogs more frequently (p < 0.01). Of the analyzed human samples, 43.9% were seropositive to heartworm and Wolbachia. Total IgE concentrations were increased in 34.5% seropositive samples and 8.1% seronegative samples. Specific IgE against heartworm was only found in human seropositive samples (17.2%). Contact with heartworm may be a risk factor for the development of allergic diseases, although further studies to elucidate the relationship between heartworm and allergies should be carried out.

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Section: Discussionmentioning

confidence: 99%

Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Montoya-Alonso

Morchón

Matos

et al. 2020

Animals

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Reactivation of latent infections in solid organ transplant recipients from sub-Saharan Africa: What should be remembered?

Silva¹,

Fernández‐Ruiz²,

Grossi³

et al. 2021

Transplantation Reviews

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Feline heartworm disease and environmental allergens hypersensitivity: is there a link?

et al. 2023

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Background Cats can be infected by Dirofilaria immitis, the causative agent of heartworm disease, characterized by respiratory signs, airway hyperreactivity, remodelling and inflammation. Allergy is a multifactorial pathology, and the role of a number of helminth parasites in the development of allergies in humans and other species has been demonstrated in many studies. The aim of the present study was to verify whether cats seropositive for D. immitis present hypersensitivity to some environmental allergens. Methods Blood samples were collected from 120 cats and tested for the presence of specific immunoglobulin G antibodies against D. immitis and for hypersensitivity to 20 allergens, using commercial allergen test kits. Results Of the 120 cats tested, 72 (60.0%) were seropositive for anti-D. immitis IgG and 55 (45.8%) showed clinical signs of heartworm disease of a respiratory nature. The results of testing with the allergen kits showed that 50.8% of cats were seropositive for ≥ 1 allergens, with the most common allergens being Dermatophagoides farinae (25.8%), Dermatophagoides pteronyssinus (20.0%), Malassezia (17.5%) and Ctenocephalides felis (14.2%). The prevalence of allergies was significantly higher—by almost threefold—in cats seropositive for D. immitis (68.1% vs. 25%). There were no significant differences between the prevalence of allergic cats and presence/absence of symptoms, and the results confirmed that symptoms were not a decisive factor for the presence of allergies. The risk for developing allergies was 6.3-fold higher in cats seropositive for D. immitis than in cats that were seronegative, confirming that seropositivity for D. immitis is a risk factor. Conclusions Cats with confirmed heartworm can develop serious respiratory signs, potentially leading to progression to permanent lung injury and predisposing cats to hyperresponsive airway disease. Previous studies have shown that seropositivity for D. immitis and Wolbachia is related to the presence of bronchoconstriction and bronchospasm in the affected cat. The results support the suspicion that contact with D. immitis may be a risk factor for the presence of allergies. Graphical abstract

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Excretion of Ascaris lumbricoides following reduced‐intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole

Cited by 3 publications

References 18 publications

Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Reactivation of latent infections in solid organ transplant recipients from sub-Saharan Africa: What should be remembered?

Feline heartworm disease and environmental allergens hypersensitivity: is there a link?

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