Excretion of corticosteroids by infants of diabetic and pre-diabetic mothers.

Cathro, D. M.; Forsyth, Constance C.

doi:10.1136/adc.40.214.583

Cited by 9 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fetus of a poorly controlled diabetic woman has hyperglycaemia causing hyperinsulinaemia in utero [6,7]. It is less certain that hyperadrenocorticism exists in these infants [8][9][10]. Although the underlying pathophysiology is unclear, hyperinsulinaemia has been implicated as a major factor in delayed lung maturation.…”

mentioning

confidence: 99%

Effects of insulin and hydrocortisone on lung tissue phosphatidyl choline and disaturated phosphatidyl choline in fetal rabbits in vivo

Patel

Rhodes

1984

Diabetologia

View full text Add to dashboard Cite

To determine the effects of insulin and hydrocortisone on lung tissue surfactant, the fetuses of New Zealand White rabbits were injected with insulin, saline (0.154 mol/l), insulin+hydrocortisone, insulin+saline or saline+hydrocortisone, or were sham-operated on day 27 of gestation. Twenty-four hours later (on day 28 of gestation) delivery was accomplished by Caesarian hysterectomy. The lung tissues were analysed for phosphatidyl choline and disaturated phosphatidyl choline. Both were higher in fetuses injected with insulin than in sham-operated control animals. The phosphatidyl choline and disaturated phosphatidyl choline were also higher in the fetuses injected with insulin+hydrocortisone than in fetuses injected with insulin or hydrocortisone alone. These results suggest that insulin increases the phosphatidyl choline and disaturated phosphatidyl choline content in lung tissue in fetal rabbits in vivo, and that in the presence of hydrocortisone, insulin appears to have an additive effect.

show abstract

mentioning

confidence: 99%