Excretion of collagen derived peptides is increased in women with stress urinary incontinence

Kushner, Leslie; Mathrubutham, Mahesh; Burney, Tracey; Greenwald, Robert A.; Badlani, Gopal H.

doi:10.1002/nau.10174

Cited by 26 publications

(19 citation statements)

References 27 publications

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“…After a 24h urine collection, the stress incontinent group had mean urinary concentrations of helical peptide α1 (I) 620-633 of 0.80 ± 0.13 μg/mg creatitine as opposed to 0.49 ± 0.06 μg/mg creatitine in the control group ( P < 0.02). [15] Chen et al established similar conclusions by showing the up-regulation of matrix metalloproteinase mRNA by 80% ( P = 0.05) which are responsible for collagen breakdown, as well as the suppression of its inhibitors by 34% ( P =0.03) which act to regulate the collagen matrix. In conjunction, there was a 60% reduction per milligram of protein in the total collagen content in women with stress incontinence in comparison to control.…”

Section: Etiology-intrinsic Factorsmentioning

confidence: 77%

Pelvic organ prolapse and stress urinary incontinence: A review of etiological factors

Patel¹,

Amrute²,

Badlani³

2007

Indian J Urol

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Although they may present with significant morbidity, pelvic organ prolapse and stress urinary incontinence are mainly afflictions that affect quality of life. To appropriately treat these entities, comprehension of the various theories of the pathophysiology is paramount. Utilizing a Medline search, this article reviews recent data concerning intrinsic (i.e., genetics, postmenopausal status) and extrinsic factors (i.e., previous hysterectomy, childbirth) leading to organ prolapse or stress incontinence.

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Section: Etiology-intrinsic Factorsmentioning

confidence: 77%

Pelvic organ prolapse and stress urinary incontinence: A review of etiological factors

Patel¹,

Amrute²,

Badlani³

2007

Indian J Urol

View full text Add to dashboard Cite

show abstract

“…After a 24-hour urine collection, the stress incontinent group had mean urinary concentrations of helical peptide α1 (I) 620-633 of 0.80 ± 0.13 μg/mg of creatinine, compared with 0.49 ± 0.06 μg/mg of creatinine in the control group (P < 0.02) [15].…”

Section: Collagen and Elastin Defi Ciencymentioning

confidence: 98%

The biochemistry of wound healing in the pelvic floor: What have we learned?

Vishwajit¹,

Fuelhase²,

Badlani

2009

Curr Bladder Dysfunct Rep

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“…In one study, women with SUI, compared to normal women, exhibited higher concentrations of matrix metalloproteinases and lower concentrations of inhibitors of collagen breakdown in peri-urethral vaginal wall tissue. [3] Other studies support an increased role of collagenases in women with SUI [8], further underscoring the vital role that collagen plays in SUI and in its surgical treatment. Synthetic sub-urethral mesh must therefore encompass several characteristics that promote healing, minimize inflammation, and exude biocompatibility.…”

Section: Why Synthetic Mesh?mentioning

confidence: 99%

“…Synthetic polypropylene mesh has a tenfold tensile force compared to normal fibrous tissue and, as such, is rarely a factor when differentiating between products [1,8]. Resistance of the mesh to deformation has been demonstrated to be consistent over time and superior to cadaveric fascia lata slings [46].…”

Section: Tensile Strengthmentioning

confidence: 99%

The use of synthetic sub-urethral slings in the treatment of female stress urinary incontinence

Feifer

Corcos

2007

Int Urogynecol J

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We set out to review the existing literature regarding the use of synthetic suburethral sling products for the treatment of female stress urinary incontinence. Products currently implanted are examined and scrutinized, and evidence regarding their efficacy and complication rates is noted. Additionally, specifics of presently utilized synthetic materials, including construction method and biocompatibility, are explored and directly correlated to currently marketed products. This investigation was undertaken with the use of the Medline database. Studies pertaining to synthetic or surgical mesh, as well as each specific suburethral sling product, are included. Our findings and ultimately our recommendations stem from the preponderance of evidence supporting the continued use of knitted, macroporous polypropelene mesh slings. Several existing marketed products detailed in the study fit this description. Specific reference is made to recent reports of vaginal erosions and deep space infections related to several specific products. A cautionary note is also made regarding the implantation of transobturator sling products currently marketed without the necessary pre-market testing, potentially placing the public at risk. From the currently available literature on biomaterials, it seems clear that knitted macroporous polypropylene is the material of choice for suburethral implantation. With respect to the means and techniques by which these mesh materials are suburethrally implanted, the surgeon's choice often dictates which method is used, but recent experience has demonstrated that the transobturator approach can be equally as effective as the traditional tension-free vaginal tape, with less-associated morbidity. Ongoing randomized controlled trials will further clarify and distinguish between methods.

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Excretion of collagen derived peptides is increased in women with stress urinary incontinence

Cited by 26 publications

References 27 publications

Pelvic organ prolapse and stress urinary incontinence: A review of etiological factors

Pelvic organ prolapse and stress urinary incontinence: A review of etiological factors

The biochemistry of wound healing in the pelvic floor: What have we learned?

The use of synthetic sub-urethral slings in the treatment of female stress urinary incontinence

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