Excretion of ciprofloxacin in sweat and multiresistant Staphylococcus epidermidis

Høiby, Niels; Jarløv, Jens Otto; Kemp, Michael; Tvede, Michael; Bangsborg, Jette; Kjerulf, Anne; Pers, Charlotte; Hansen, Hanne D.

doi:10.1016/s0140-6736(96)09229-x

Cited by 128 publications

(87 citation statements)

References 25 publications

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“…Use of aminoglycosides and fluoroquinolones may also stand independently along with presence of chronic ulcers undergoing antibiotic therapy and could promote the acquisition of MRSA by eradicating susceptible microorganisms such as MSSA. 41 Subinhibitory concentrations of ciprofloxacin induced the production of fibronectin-binding proteins and increased the adhesion to fibronectin-coated surfaces in vitro, promoting host colonization. 42 Fluoroquinolones might influence oxacillin resistance by selective inhibition or by killing of the more susceptible subpopulations in heteroresistant S. aureus.…”

Section: Resultsmentioning

confidence: 99%

Length of exposure to the hospital environment is more important than antibiotic exposure in healthcare associated infections by methicillin-resistant Staphylococcus aureus: a comparative study

Baraboutis¹,

Tsagalou²,

Papakonstantinou³

et al. 2011

Braz J Infect Dis

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Objectives: Both total antimicrobial use and specific antimicrobials have been implicated as risk factors for healthcare-associated methicillin-resistant Staphylococcus aureus (HCA-MRSA) infection. The aims of this study were: (I) to explore predictors of a new HCA-MRSA infection in comparison with a new healthcare-associated methicillin-sensitive Staphylococcus aureus (HCA-MSSA); (II) to thoroughly assess the role of recent antibiotic use qualitatively and quantitatively. Methods: The time-period for our study was from October 1997 through September 2001. Through applying strict criteria, we identified two groups of inpatients, one with a new HCA-MRSA infection and one with a new HCA-MSSA infection. We recorded demographic, clinical and antibiotic use-related data up to 30 days before the positive culture date. Results: We identified 127 and 70 patients for each group, respectively. Two logistic regression models were carried out to assess the role of antimicrobial use (qualitatively and quantitatively). In model I, duration of hospital stay, presence of chronic wounds, aminoglycoside and fluoroquinolone use retained statistical significance. In model II, duration of hospital stay and history of intubation during the last month stood out as the only significant predictors of a subsequent HCA-MRSA infection. No significant differences in outcome were noted. Conclusions: The length of exposure to the hospital environment may be the best predictor of a new HCA-MRSA infection. Use of aminoglycosides and fluoroquinolones may also stand independently along with presence of chronic ulcers and surgical procedures. No independent association between quantitative antibiotic use and subsequent HCA-MRSA infection was documented. Keywords: methicillin-resistant Staphylococcus aureus; Staphylococcus aureus; antibacterial agents; fluoroquinolones. significant risk factor for MRSA acquisition and infection from most, but not all, case-control and cohort studies. 4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Both total antimicrobial use as well as specific antimicrobial classes have been implicated. [11][12][13][14][15][16][17][18]24,25 Included in these classes are β-lactamic antibiotics, 14,26-33 cephalosporins, 11,12,16,22,29 aminoglycosides, 22,33,34 macrolides, 27 glycopeptides 15,[27][28][29]34 and fluoroquinolones (FQs). 6,11,12,14,[26][27][28][29][35][36][37] A relatively recently published meta-analysis detected a clear association between exposure to antibiotics and MRSA isolation. Significant risk ratios were found for FQs, glycopeptides, cephalosporins and other β-lactams. 38 A prediction model, aimed at identifying MRSA bacteremia, predicted that 80% of the nosocomial bacteremias would be resistant to methicillin if patients had experienced antimicrobials prior to the onset. This model also indicated that there were no differences between antibiotics in the prediction of MRSA. 29

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Section: Resultsmentioning

confidence: 99%

Length of exposure to the hospital environment is more important than antibiotic exposure in healthcare associated infections by methicillin-resistant Staphylococcus aureus: a comparative study

Baraboutis¹,

Tsagalou²,

Papakonstantinou³

et al. 2011

Braz J Infect Dis

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“…High concentration of bacteria in one place, probably as a presence of resistant strains of the subpopulation, and sometimes, limited concentration of quinolones, stimulate the emergence of resistant mutants (31). Quinolones affects the activity of DNA gyrase, weakening the bonds of DNA chain, whereas topoisomerase IV separates DNA chains.…”

Section: Re Si Sta Nce T O Qu I Nol One Smentioning

confidence: 99%

“…The change in amino acid sequences, in the corresponding region of the DNA enzyme complex (quinolone resistance determining region, QRDR), reduces the affinity of the quinolones to the target sites. GrlA subunit (ParC) of topoisomerase IV and GyrA subunit of DNA gyrase are considered as the most common sites of the mutations that lead to the emergence of resistance to these drugs (31,32). Sometimes, a single amino acid mutation is sufficient to get a clinical manifestation of the resistance, but for fluoroquinolones the occurrence of additional mutations is necessary.…”

Section: Re Si Sta Nce T O Qu I Nol One Smentioning

confidence: 99%

Resistance in Staphylococcus Aureus: The Never-Ending Story

Orlović¹,

Miljković-Selimović²,

Dinić³

et al. 2016

Acta Facultatis Medicae Naissensis

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SUMMARYCombating Staphylococcus aureus (S. aureus) infections using antibacterial drugs is actually an ongoing effort to overcome resistance mechanism of this microorganism. In this paper, we discussed (1) the mechanisms of resistance to some of the most commonly used antimicrobial agents in the treatment of S. aureus: methicillin, vancomicyn and quinolones. In addition, (2) efflux pump mechanisms involved in maintaining homeostasis in the presence of compounds that inhibit S. aureus growth and reproduction, as well as mechanisms of resistance to a number of antibiotics, have been reviewed.

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“…The role of these agents for resistant of S. epidermidis is well recognized, especially with quinolones. 68 SHEA guidelines lay emphasis on good antibiotic stewardship and, specifically, on fluoroquinolone control.…”

Section: Control Of the Use Of Antimicrobial Agentsmentioning

confidence: 99%

Prevention strategies for methicillin-resistant Staphylococcus aureus (MRSA) in Latin America

Labarca¹,

Salles²

2010

Braz J Infect Dis

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After the first reports of the emergence of methicillin-resistant Staphylococcus aureus (MRSA) in the 1970s, numerous measures intended to prevent its transmission were initiated in hospitals. However, in most cases, large-scale measures failed to be implemented and the transmission of MRSA has since led to a global pandemic. Presently, doubts still remain about the best approach to prevent and control MRSA and more often than not, control measures are not implemented. Therefore, we review here the current situation in Latin America with respect to existing policies for control of MRSA, and evaluate the evidence for control measures in hospitals and the community. We look at the risk factors for infection and transmission of MRSA between hospital patients and within specific populations in the community, and at the effect of antibiotic usage on the spread of MRSA in these settings. Finally, we summarize recommendations for the prevention and control of MRSA, which can be applied to the Latin American hospital environment and community setting.

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Excretion of ciprofloxacin in sweat and multiresistant Staphylococcus epidermidis

Cited by 128 publications

References 25 publications

Length of exposure to the hospital environment is more important than antibiotic exposure in healthcare associated infections by methicillin-resistant Staphylococcus aureus: a comparative study

Length of exposure to the hospital environment is more important than antibiotic exposure in healthcare associated infections by methicillin-resistant Staphylococcus aureus: a comparative study

Resistance in Staphylococcus Aureus: The Never-Ending Story

Prevention strategies for methicillin-resistant Staphylococcus aureus (MRSA) in Latin America

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