Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases

Wang, Jia Hui; Chen, Ke Qi; Jiang, Jun Xing; Li, Huan Yong; Pan, Jun; Su, Ji Yan; Wang, Lin; Hu, Yang; Mi, Xiang Nan; Yi, Xin; Gao, Qin; Zhao, Xiang; Xiao, Fei; Luo, Huan

doi:10.1007/s13318-019-00576-6

Cited by 2 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Twenty pathways, such as signaling pathways, are involved. Modern pharmacological studies have shown that hydroxybenzoic acid, hydroxybenzaldehyde, and 3, 4‐dihydroxybenzoic acid methyl ester all have varying degrees of antibacterial, anti‐inflammatory, anti‐corrosion, anti‐tumor, and deodorizing activity 18,26–30 . To further determine the Q‐markers of PFH, HCA, PCA, and OPLS‐DA, pattern recognition techniques were used to analyze the major components affecting the quality of PFH medicinal materials.…”

Section: Resultsmentioning

confidence: 99%

Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis

Li,

Cheng,

Zhang

et al. 2024

Phytochemical Analysis

View full text Add to dashboard Cite

IntroductionPolygala fallax Hemsl (PFH) is a widely used herbal medicine in Guangxi, China. At present, research on PFH mainly focuses on extraction technology and cultivation, lacking quality control standards for systematic evaluation.ObjectivesThe study aimed to assess the quality of PFH from different sources and to predict markers that would help assess quality.MethodsFingerprinting of 15 batches of PFH samples was performed by ultra‐high performance liquid chromatography (UPLC) and similarity was assessed using hierarchical cluster analysis (HCA), principal component analysis (PCA), and orthogonal partial least squares discrimination (OPLS‐DA). Differential components were screened by mathematical analysis, and a “component‐target‐pathway” network map was constructed in combination with network pharmacology, quality markers (Q‐markers) of PFH were predicted, and quantitative analysis was performed.ResultsFifteen batches were fingerprinted for PFH, with 11 common peaks, and peak 5 was identified as 4‐hydroxybenzoic acid, which was generally consistent with the results of HCA, PCA, and OPLS‐DA. Network pharmacology screened 18 potential compounds, 45 core targets, and 20 key pathways, integrating fingerprinting, pattern recognition, and network pharmacology methods. One of the potential Q‐markers that can identify the principle of testability, efficacy, and specificity is 4‐hydroxybenzoic acid, whose content ranges from 0.0188 to 1.4517 mg/g.ConclusionThe potential Q‐markers of PFH were predicted by integrating fingerprinting, pattern recognition, and network pharmacological analysis, which provided a scientific basis for the overall control and evaluation of the quality of PFH and a theoretical reference for the study of the quality standard of multi‐base traditional Chinese medicine.

show abstract

Section: Resultsmentioning

confidence: 99%

Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis

Li,

Cheng,

Zhang

et al. 2024

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

Potansiyel Biyolojik Aktif Metil-4,5-dimetoksi-2-(2-(4-metoksifenil)-2-oksoetil)benzoat’ın Sentezi

Aksu

2021

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

Potansiyel Biyolojik Aktif Metil-4,5-dimetoksi-2-(2-(4-metoksifenil)-2-oksoetil)benzoat'ın SenteziKadir AKSU 1* ÖZET: Benzoik asit, metil benzoat bileşikleri ve bunların türevleri oldukça geniş bir alanda aktivite gösteren, sentezi organik kimyacılar için önemli olan kıymetli bileşiklerdir. Bu çalışmada 3,4dimetoksisinamik asitten başlanarak bir seri reaksiyon sonucunda benzoik asitin metil ester türevi olan metil-4,5-dimetoksi-2-(2-(4-metoksifenil)-2-oksoetil)benzoat'ın sentezi etkin bir şekilde gerçekleştirildi. Sentezlenen bileşiğin yapısı 1 H NMR ve 13 C NMR spektrumları ile karakterize edildi.Anahtar Kelimeler: Benzoik asit, sinamik asit, poli sübstitüe metil benzoat Synthesis of Potentially Biologically Active Methyl-4,5-dimethoxy-2-(2-(4-methoxyphenyl)-2oxoethyl)benzoateABSTRACT: Benzoic acid, methyl benzoate compounds and their derivatives are valuable compounds that have a wide range of activities and synthesis of these is important for organic chemists. In this study, the synthesis of methyl-4,5-dimethoxy-2-(2-(4-methoxyphenyl)-2-oxoethyl) benzoate, methyl ester derivative of benzoic acid, was carried out effectively as a result of a series of reactions starting from 3,4-dimethoxycinnamic acid. The structure of synthesized compound was characterized by 1 H NMR and 13 C NMR spectra.

show abstract

Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases

Cited by 2 publications

References 33 publications

Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis

Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis

Potansiyel Biyolojik Aktif Metil-4,5-dimetoksi-2-(2-(4-metoksifenil)-2-oksoetil)benzoat’ın Sentezi

Contact Info

Product

Resources

About