Excretion, Distribution and Fate of Bismuth Under Clinical Conditions.

Abstract

276 SCIENTIFIC PROCEEDINGSand pregnant guinea pig uterus were stimulated by both the amine and epinephrine, while the nonpregnant cat uterus was stimulated by the amine but relaxed by epinephrine, thus again resembling tyramine and ephedrine. Bronchi constricted from histamine and pilocarpine were not effectively relaxed! by phenylethanolamine or ephedrine, while epinephrine caused relaxation ; additional tests are necessary. Administered subcutaneously and intravenously, phenylethanolamine was less effective than epinephrine, about as effective as tyramine, but more effective than ephedrine in preventing the experimental edema of paraphenylenediamine and equally as effective as epinephrine in dionine chemosis, but ineffective (also tyramine and ephedrine) against mustard oil chemosis and dermatitis. Local application of 1% concentrations in the nose of human subjects shrank congestetl nasal niucosae and turbinates promptly without objectionable irritation, the effects persisting 2 to 3 hours, thus resembling ephedrine.Provisionally, the pharmacological actions of phenylethanolaminc. resemble those of tyramine and ephedrine more than epinephrine. Further tests are being made experimentally and clinically.