Excretion and Retention of Radioactive Strontium in Normal Men Following a Single Intravenous Injection

The patterns of retention and excretion of 85Sr in mice, rats and rabbits are studied up to 70 -260 days after a single injection. The results can be fitted with power functions until 100 days, but after that the exponents increase gradually with time.The data on retention in these animals are compared with human results which are known up to 400 days. On the assumption that the patterns of the retention obtained by these small animals are epitomes of that in humans, it is suggested that the long-term retention of Sr in humans will be expressed roughly by 0.80 t P 0 e 3 O until 6000 days after injection. The ratios of urine to total excretion are also studied in these animals. The values are compared with human results.

Section: Extrapolation To Long-term Retention In Humansmentioning

confidence: 96%

Retention and Excretion of Strontium-85 in Mice, Rats and Rabbits-extrapolation to Long-Term Retention in Humans

Fujita¹,

Iwamoto²

1965

“…Using workers. (1)(2)(3)(4)(5)(6)(7)(8) Most of the studies were tracer these data, assessment of body burdens of 90Sr experiments for volunteers Or fOllOW-UP after from urinalysis is discussed. Last, it is suggested accidental intakes and mainly Provided data that fecal level can be used as a substitute for on single exposures.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Ingestion, Accumulation and Excretion of Fallout 90Sr in Man on a Long-term Scale

Fujita¹,

Iwamoto²,

Kondo³

et al. 1969

Determination was made of the levels of fallout 90Sr in the diets and excreta from several volunteers from 1962 to 1967 in Tokai. Estimation of the total body burden of sOSr was carried out by combining the dietary intake with a body retention formula of a single dose. It is suggested that fecal level can be used as a substitute for dietary level approximately.Assessment of the body burden from urinalysis is discussed for chronic exposure.

“…(12) as the relevant data were not available to us. Nevertheless, the relatively large standard deviation indicates the necessity of treating the results of excretion analysis data with great caution.…”

mentioning

confidence: 95%

Study of Internal Contamination With Strontium-90 and Radium-226 in Man in Relation to Clinical Findings. Second Report

Mueller¹,

Klener²,

Tuscany³

et al. 1966

The results of a follow up of a group of fifty-two persons carrying body burdens of 90Sr and zzsRa for a period of about 2500 days are given. The body burdens vary in the group from less than 10 per cent of the maximum permissible to somewhat more than 100 per cent of the maximum permissible burden. The urinary O"Sr excretion data observed up to now do not differ significantly from a power function model with the exponent b = 0.215. The threeexponential model described by other authors is, however, no longer valid and a fourth exponential with a half-life of about 700 days had to be added. A fifth exponential with a still longer half-life was predicted by extrapolation. The large fluctuation in the excretion observed from day to day and at different times of the day could be greatly diminished by relating it to calcium excretion.No significant clinical changes could be observed in the exposed group except the signs of radiation dermatitis in some cases. A small but statistically significant increase in the number of red cells, haemoglobin and haematocrit values could be detected, when comparing the whole group to a group of healthy prospective blood donors. There was, however, no significant difference in these indicators when comparing persons with different levels of body burdens within the group.Karyological investigation of bone marrow cells showed a statistically significant increase in the occurrence of aneuploid cells as compared to healthy controls. Differences in the occurrence of aneuploid cells found in groups with different levels of body burden are at this stage of the study not statistically significant. A significant increase in the rate of chromosomal aberrations could be demonstrated in cases with cumulative body burdens higher than 10 per cent of the maximum permissible. A single cell with a haploid set of chromosomes was found in a female patient with the highest body burden.An increased rate of nonagglutinable red cells was a frequent but not regular finding in the exposed group and no relation to the size of the body burden could be established.