Excitonic AND Logic Gates on DNA Brick Nanobreadboards

Abstract

A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems.

FRET efficiency and antenna effect in multi-color DNA origami-based light harvesting systems

“…21,22 Since every staple strand can be addressed and modied individually and separately, different moieties can be arranged with a high local control since the exact position of each staple strand in the DNA origami structure is known. DNA origami structures have been used to create highly sensitive SERS substrates by attaching gold nanoparticle dimers, [23][24][25] to analyze DNA strand breaks induced by low energy electrons 26,27 and UV photons 28 and to arrange different uo-rophores 29,29,30 at precise distances to create nanoscale photonic devices which can be used for example as photonic wires, 15,18 to resolve conformational changes of biomolecules, [31][32][33][34] as logic gates 35,36 and articial light harvesting complexes. 8,10,18 The light harvesting efficiency is in this context typically expressed as an antenna effect (AE), i.e.…”

Implementation of Probabilistic Algorithms by Multi‐chromophoric Molecular Networks with Application to Multiple Travelling Pathways

“…Even if this is still a small fraction of the infinite variety of possible topologies, the capability of designing and synthetizing multi‐chromophore structures make them promising building blocks for the efficient implementation of probabilistic algorithms. Experimental realization of molecular devices built by assembling DNA bricks in programmable nanobreadboards on which chromophores can be rapidly and easily repositioned has been recently demonstrated . An important point to consider in the practical implementation of the proposed logic Scheme is the overlap between the spectral features of the different chromophores.…”

Utilizing the Organizational Power of DNA Scaffolds for New Nanophotonic Applications

“…Some possible solutions to this may be found either in creating extremely dense DNA structures such as Yin's bricks which may minimize such breathing or, alternatively, chemically cross‐linking the DNA strands to each other after formation . Indeed some preliminary work utilizing DNA brick nanobreadboard structures to create FRET‐based excitonic logic gates capable of repeated dynamic switching have already been reported . An important issue to be appreciated in conjugation with the choice of which DNA assembly approach to utilize is that each requires design knowledge and comes with its own set of benefits and liabilities for a give application.…”