Excitatory Interactions between Olfactory Processing Channels in the Drosophila Antennal Lobe

Olsen, Shawn R.; Bhandawat, Vikas; Wilson, Rachel I.

doi:10.1016/j.neuron.2007.05.006

Cited by 59 publications

(107 citation statements)

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“…Accumulating evidence over the last few years from different insects, however, emphasises that LNs that tend to have broad multiglomerular ramifications ( Figure 7A), and thus provide a scaffold for crosstalk between channels, play a major role in shaping the output response of the processing channels (reviewed by , see also Bhandawat et al 2007, Olsen and Wilson 2008, Olsen et al 2007, Root et al 2007, Shang et al 2007, Wilson and Laurent 2005. In addition, intraglomerular events appear to have a significant influence on these processes (Bhandawat et al 2007, Christensen et al 2000, Kazama and Wilson 2008, Olsen and Wilson 2008, Wilson et al 2004). …”

Section: Intra-and Interglomerular Synaptic Interactions In the Antenmentioning

confidence: 99%

“…As a result, detection and discrimination thresholds are increased as evidenced by psychophysical data from A. mellifera and M. sexta indicating that the salient odour signal is lost (Hosler et al 2000, Mwilaria et al 2008. In D. melanogaster, the increased output from the processing channels has been linked to the activity of excitatory cholinergic LN connections between glomeruli (Olsen et al 2007, Root et al 2007, Shang et al 2007, driven by direct monosynaptic input from ORNs (Kazama and Wilson 2008). This type of cholinergic connection has, so far, neither been supported physiologically nor immunohistologically in other insect olfactory systems (Homberg and Müller 1999).…”

Section: Intra-and Interglomerular Synaptic Interactions In the Antenmentioning

confidence: 99%

“…Instead, available data support alternative pathways for the observed phenomenon (Christensen et al 1998). In D. melanogaster, cholinergic LNs are believed to broaden the tuning of PNs resulting in an increased separation between odour representations in PN coding space (Bhandawat et al 2007, Wilson et al 2004. As a consequence, PNs are believed to use their dynamic range more efficiently by protecting the sensory representations from noise contamination added at later stages in the olfactory processing.…”

Section: Intra-and Interglomerular Synaptic Interactions In the Antenmentioning

confidence: 99%

“…Odour-evoked ORN signals generally seem to be amplified in the postsynaptic PN (Bhandawat et al 2007, Boeckh and Ernst 1987, Christensen and Hildebrand 1994, Hansson et al 1991, Hartlieb et al 1997. This increase may be partly explained by the spatial summation of convergent ORNs onto PNs (reviewed by Hansson and Christensen 1999, see also Kazama and Wilson 2008).…”

Section: Additional Features Of the Olfactory Signals Relayed To Highmentioning

confidence: 99%

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Olfaction in vector-host interactions

Takken¹,

Knols²

2010

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Section: Intra-and Interglomerular Synaptic Interactions In the Antenmentioning

confidence: 99%

Section: Intra-and Interglomerular Synaptic Interactions In the Antenmentioning

confidence: 99%

Section: Intra-and Interglomerular Synaptic Interactions In the Antenmentioning

confidence: 99%

Section: Additional Features Of the Olfactory Signals Relayed To Highmentioning

confidence: 99%

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Olfaction in vector-host interactions

Takken¹,

Knols²

2010

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“…6a). Or10a loss-of-function flies (Or10a f03694 ) 25 retain their preference for 2AA (18% (±5% s.d.) versus 50% ( ± 10% s.d.…”

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confidence: 99%

The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies

et al. 2014

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Bacteria contaminate insects and secrete metabolites that may affect insect behaviour and potentially fitness through unknown mechanisms. Here we show that the 'grape-like' odorant 2-aminoacetophenone (2AA), secreted by Pseudomonas aeruginosa (a ubiquitous opportunistic human pathogen), facilitates attraction to food for several fly species including Musca domestica, Ceratitis capitata and Drosophila melanogaster. Constant feeding on 2AA increases the level of long-term colonization of the flies' intestine by P. aeruginosa. Odour perception is necessary for enhanced attraction to food containing 2AA, and expression in the Drosophila olfactory organs of odorant receptors Or49b and Or10a potentiates, while expression of Or85a inhibits, preference for 2AA. Our study shows that 2AA lures the flies to the bacterial source and increases the extent of colonization of the fly intestine by the bacteria that produce it, as a means to facilitate bacterial dissemination to new locations.

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Comprehensive morphological identification and GABA immunocytochemistry of antennal lobe local interneurons in Bombyx mori

Seki

Kanzaki

2007

J of Comparative Neurology

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The insect antennal lobe (AL) is the structural and functional analog of the olfactory bulb of mammals, in which odor information is spatially and/or temporally represented by functional glomerular units. Local interneurons (LNs) play critical roles through intra- and interglomerular communication to shape the output from the AL to higher brain centers; however, the function and even the components of LNs are unclear. We have used morphological and immunocytochemical approaches to examine LNs in the silkworm moth, Bombyx mori. First, we comprehensively analyzed the morphological variation of LNs. One hundred fifty-three AL LNs were intracellularly stained, analyzed in three dimensions with a confocal microscope, and subdivided into five morphological types based on differences in the arborization region in the AL and dendritic profiles within the glomeruli. Two global multiglomerular types arborized in the macroglomerular complex (MGC) and in most ordinary glomeruli, and the other three oligoglomerular types innervated some ordinary glomeruli with or without the MGC. Second, we performed double-labeling of Lucifer Yellow staining of a single LN combined with gamma-aminobutyric acid (GABA) immunocytochemistry. The two global multiglomerular types and two of the oligoglomerular types were GABA-immunoreactive, but the third oligoglomerular type, which innervates the MGC and some ordinary glomeruli, included some GABA-immunonegative neurons, suggesting the existence of a non-GABAergic subtype. These results suggest that the complex neural circuits of the AL are composed of several morphologically different types of LNs, most of which are inhibitory.

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Excitatory Interactions between Olfactory Processing Channels in the Drosophila Antennal Lobe

Cited by 59 publications

References 0 publications

Olfaction in vector-host interactions

Olfaction in vector-host interactions

The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies

Comprehensive morphological identification and GABA immunocytochemistry of antennal lobe local interneurons in Bombyx mori

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