1986
DOI: 10.1111/j.1476-5381.1986.tb10233.x
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Excitatory effect of Clostridium perfringens alpha toxin on the rat isolated aorta

Abstract: Clostridium perfringens alpha toxin caused contraction of the isolated aorta of the rat in a dose‐dependent manner. The contractile action caused by the toxin was inhibited or abolished by calcium antagonists such as nifedipine, verapamil and cinnarizine, or a Ca‐free medium, but was not affected by phentolamine, chlorpheniramine, atropine, tetrodotoxin or a low Na medium. The toxin stimulated Ca uptake into the aorta in a dose‐dependent manner. 8‐N,N'‐diethylaminooctyl‐3,4,5‐trimethoxybenzoate (TMB‐8) blocked… Show more

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Cited by 45 publications
(29 citation statements)
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“…The response to the toxin therefore seems to be the result of a direct effect on the aorta. Alpha-toxin-induced contractions were inhibited by Ca channel blockers such as verapamil and nifedipine [16]. Furthermore, the toxin-induced contractionswere not observed in Ca-free medium.…”
Section: Activation Of the Arachidonic Acid Cascade By Alpha-toxinmentioning
confidence: 78%
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“…The response to the toxin therefore seems to be the result of a direct effect on the aorta. Alpha-toxin-induced contractions were inhibited by Ca channel blockers such as verapamil and nifedipine [16]. Furthermore, the toxin-induced contractionswere not observed in Ca-free medium.…”
Section: Activation Of the Arachidonic Acid Cascade By Alpha-toxinmentioning
confidence: 78%
“…Thus, the toxin-induced contractions of the isolated rat aorta associated with the production of TXA 2 required an intact endothelium. Furthermore, TMB-8 (intracellular Ca 2+ antagonist), trifluoperazine, W-7(calmodulin inhibitor) and H-7 (PKC inhibitor) significantly blocked the toxininduced contractions [16]. From these observations, in endothelial cells of the rat aorta, alpha-toxin stimulates phosphotidylinositol metabolism and arachidonic acid release, leading to the production of TXA 2 and the phosphorylation of myosin light chain which then elicits contractions of the adjacent aorta smooth muscle ( Figure 2).…”
Section: Activation Of the Arachidonic Acid Cascade By Alpha-toxinmentioning
confidence: 87%
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