Excitatory amino acid release in the locus coeruleus during naloxone-precipitated morphine withdrawal in adjuvant arthritic rats

Hoshi, Katsuji; Yamamoto, Akira; Ishizuki, Satoshi; Fujihira, Eiichi; Ichihara, Kazuo

doi:10.1007/pl00000201

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…As opposed to the suppression of extracellular glutamate levels that is characteristic of acute morphine exposure, morphine withdrawal is characterized by increased overflow of glutamate in regions such as the locus coeruleus [311,312], NAcc [272,313], and hippocampus [278]. This withdrawal-induced increase in glutamate overflow is accompanied by reductions in Group II-mediated LTD in the NAcc [314], likely due to a desensitization of presynaptic mGluR2/3 receptors.…”

Section: Glutamate and Opiatesmentioning

confidence: 99%

Glutamatergic substrates of drug addiction and alcoholism

Gass

Olive

2008

Biochemical Pharmacology

435

367

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The past two decades have witnessed a dramatic accumulation of evidence indicating that the excitatory amino acid glutamate plays an important role in drug addiction and alcoholism. The purpose of this review is to summarize findings on glutamatergic substrates of addiction, surveying data from both human and animal studies. The effects of various drugs of abuse on glutamatergic neurotransmission are discussed, as are the effects of pharmacological or genetic manipulation of various components of glutamate transmission on drug reinforcement, conditioned reward, extinction, and relapse-like behavior. In addition, glutamatergic agents that are currently in use or are undergoing testing in clinical trials for the treatment of addiction are discussed, including acamprosate, N-acetylcysteine, modafinil, topiramate, lamotrigine, gabapentin and memantine. All drugs of abuse appear to modulate glutamatergic transmission, albeit by different mechanisms, and this modulation of glutamate transmission is believed to result in long-lasting neuroplastic changes in the brain that may contribute to the perseveration of drug-seeking behavior and drug-associated memories. In general, attenuation of glutamatergic transmission reduces drug reward, reinforcement, and relapse-like behavior. On the other hand, potentiation of glutamatergic transmission appears to facilitate the extinction of drug-seeking behavior. However, attempts at identifying genetic polymorphisms in components of glutamate transmission in humans have yielded only a limited number of candidate genes that may serve as risk factors for the development of addiction. Nonetheless, manipulation of glutamatergic neurotransmission appears to be a promising avenue of research in developing improved therapeutic agents for the treatment of drug addiction and alcoholism.

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Section: Glutamate and Opiatesmentioning

confidence: 99%

Glutamatergic substrates of drug addiction and alcoholism

Gass

Olive

2008

Biochemical Pharmacology

435

367

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“…In this connection, the cerebral 5-HT system is associated with anxiety-related behavior (Gonzalez et al, 2000;Langen et al, 2002) and the results of many animal studies indicate that increased 5-HT activity results in increased anxiety and that reducing 5-HT reduces anxiety (Langen et al, 2002). In our previous experiment, the increase in activity of the serotonergic systems in the concurrent administration of tryptophan and ethanol temporally correlated to behavioral signs (Hoshi et al, 1997(Hoshi et al, , 2000Hayashi et al, 2003Hayashi et al, , 2004Bandoh et al, 2004). In the present study, the alteration of behaviors such as teeth-chattering, sniffing and rearing in Table 1 may result from combined treatmentinduced neuronal activation in both the frontal cortex and the dorsal raphe serotonergic systems.…”

Section: Discussionmentioning

confidence: 83%

“…It is known that the neurotransmission in both the locus coeruleus neurons and the dorsal raphe nucleus is closely related to behavioral signs (Rasmussen et al, 1990;Aghajanian et al, 1994;Kaehler et al, 1999;Hoshi et al, 1997Hoshi et al, , 2000Hayashi et al, 2003Hayashi et al, , 2004. In this connection, the cerebral 5-HT system is associated with anxiety-related behavior (Gonzalez et al, 2000;Langen et al, 2002) and the results of many animal studies indicate that increased 5-HT activity results in increased anxiety and that reducing 5-HT reduces anxiety (Langen et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Alteration of 5-Hiaa Levels in Frontal Cortex and Dorsal Raphe Nucleus in Rats Treated With Combined Administration of Tryptophan and Ethanol

et al. 2006

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-The present studies sought to investigate the effect of tryptophan alone or coadministration of tryptophan and ethanol on the interaction of central frontal cortex and dorsal raphe nucleus serotonergic functional activities by utilizing in vivo microdialysis. Tryptophan (50 mg/kg, i.p.) led to a significant increase in the levels of 5-HIAA, a metabolite of serotonin (5-HT), in the dorsal raphe nucleus, but not in the frontal cortex. Coadministration of tryptophan and ethanol caused very marked increases in 5-hydroxyindoleacetic acid (5-HIAA) levels in both the frontal cortex and the dorsal raphe nucleus, although ethanol (1.25 g/kg) did not change 5-HIAA levels in both areas. Moreover, the application of WAY100635 (10 μM), 5-HT 1A antagonist, into the frontal cortex after coadministration caused a marked increase in 5-HIAA levels in the frontal cortex and a decrease in the levels in the dorsal raphe nucleus, although WAY100635 alone had no effect on these levels. This may suggest that WAY100635-induced increase of 5-HIAA levels in the frontal cortex resulted from negative feedback following the blockade of serotonergic 5-HT 1A autoreceptors, and that this increase in 5-HIAA levels decreased 5-HIAA levels in the dorsal raphe nucleus by preventing the activation of dorsal raphe 5-HT 1A autoreceptors. WAY100635 into the dorsal raphe nucleus did not significantly change 5-HIAA levels in both areas. This may indicate that the blockade of dorsal raphe 5-HT 1A autoreceptors by WAY100635 resulted in unchanged 5-HIAA levels in the frontal cortex. Behavioral sign of teeth-chattering was markedly observed following the coadministration and in combination with WAY100635.These results may suggest that the increased 5-HIAA levels in both areas after coadministration are indicative of the interrelation via activation of serotonergic neurons, and that the increased levels are partly responsible for behavioral activation of rats.

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Noradrenaline release in rat locus coeruleus is regulated by both opioid andα2 -adrenoceptors

Nakaï

Hayashi

Ichihara

et al. 2002

Pharmacological Research

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Excitatory amino acid release in the locus coeruleus during naloxone-precipitated morphine withdrawal in adjuvant arthritic rats

Abstract: These results show that the attenuation of Glu and Asp release from the LC in the adjuvant arthritic rats might explain the anti-inflammatory and analgesic effects of mu-opioids in adjuvant arthritic rats.

Cited by 9 publications

References 24 publications

Glutamatergic substrates of drug addiction and alcoholism

Glutamatergic substrates of drug addiction and alcoholism

Alteration of 5-Hiaa Levels in Frontal Cortex and Dorsal Raphe Nucleus in Rats Treated With Combined Administration of Tryptophan and Ethanol

Noradrenaline release in rat locus coeruleus is regulated by both opioid andα2 -adrenoceptors

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