Excitatory actions of GABA in the intact neonatal rodent hippocampus in vitro

Valeeva, Guzel; Valiullina, Fliza; Khazipov, Roustem

doi:10.3389/fncel.2013.00020

Cited by 68 publications

(46 citation statements)

References 77 publications

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“…During the early phase of embryonic development, GABA A Rs show excitatory activity. This GABA excitation property is also present in rodent hippocampus within the first postnatal week (Valeeva et al, 2013). …”

Section: Gaba Roles In Neurogenesismentioning

confidence: 99%

“…In early neuronal development, predominant expression of NKCC1 and absence of KCC2 results in high [Cl − ] i in immature neurons (Kanaka et al, 2001; Wang et al, 2002). In late neuronal development stages, however, a gradual upregulation of the KCC2 drains out the intracellular Cl − , eventually leading GABA to become inhibitory (Dzhala et al, 2005; Achilles et al, 2007; Valeeva et al, 2013). …”

Section: Gaba Roles In Neurogenesismentioning

confidence: 99%

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Novel functions of GABA signaling in adult neurogenesis

Pontes

Zhang

2013

Front. Biol.

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Neurotransmitter gamma-aminobutiric acid (GABA) through ionotropic GABAA and metabotropic GABAB receptors plays key roles in modulating the development, plasticity and function of neuronal networks. GABA is inhibitory in mature neurons but excitatory in immature neurons, neuroblasts and neural stem/progenitor cells (NSCs/NPCs). The switch from excitatory to inhibitory occurs following the development of glutamatergic synaptic input and results from the dynamic changes in the expression of Na+/K+/2Cl− co-transporter NKCC1 driving Cl− influx and neuron-specific K+/Cl− co-transporter KCC2 driving Cl− efflux. The developmental transition of KCC2 expression is regulated by Disrupted-in-Schizophrenia 1 (DISC1) and brain-derived neurotrophic factor (BDNF) signaling. The excitatory GABA signaling during early neurogenesis is important to the activity/experience-induced regulation of NSC quiescence, NPC proliferation, neuroblast migration and newborn neuronal maturation/functional integration. The inhibitory GABA signaling allows for the sparse and static functional networking essential for learning/memory development and maintenance.

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Section: Gaba Roles In Neurogenesismentioning

confidence: 99%

Section: Gaba Roles In Neurogenesismentioning

confidence: 99%

Novel functions of GABA signaling in adult neurogenesis

Pontes

Zhang

2013

Front. Biol.

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“…During embryonic and early postnatal development ionotropic GABA receptors mediate in pyramidal neurons depolarizing membrane responses (Mueller et al, 1984; Ben-Ari et al, 1989; Owens et al, 1996; Lamsa et al, 2000; Achilles et al, 2007; Valeeva et al, 2013). These depolarizing GABAergic responses are caused by Cl - efflux via GABA A receptors due to the high intracellular Cl - concentration in developing neurons (Ben-Ari et al, 2012), and play an essential role for the trophic actions of GABA during early development (Ben-Ari, 2002; Represa and Ben-Ari, 2005; Wang and Kriegstein, 2009; Kilb et al, 2011; but see Cancedda et al, 2007).…”

Section: Development Of Extrasynaptic and Synaptic Gabaergic Transmismentioning

confidence: 99%

Role of tonic GABAergic currents during pre- and early postnatal rodent development

Kilb¹,

Kirischuk²,

Luhmann³

2013

Front. Neural Circuits

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In the last three decades it became evident that the GABAergic system plays an essential role for the development of the central nervous system, by influencing the proliferation of neuronal precursors, neuronal migration and differentiation, as well as by controlling early activity patterns and thus formation of neuronal networks. GABA controls neuronal development via depolarizing membrane responses upon activation of ionotropic GABA receptors. However, many of these effects occur before the onset of synaptic GABAergic activity and thus require the presence of extrasynaptic tonic currents in neuronal precursors and immature neurons. This review summarizes our current knowledge about the role of tonic GABAergic currents during early brain development. In this review we compare the temporal sequence of the expression and functional relevance of different GABA receptor subunits, GABA synthesizing enzymes and GABA transporters. We also refer to other possible endogenous agonists of GABAA receptors. In addition, we describe functional consequences mediated by the GABAergic system during early developmental periods and discuss current models about the origin of extrasynaptic GABA and/or other endogenous GABAergic agonists during early developmental states. Finally, we present evidence that tonic GABAergic activity is also critically involved in the generation of physiological as well as pathophysiological activity patterns before and after the establishment of functional GABAergic synaptic connections.

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“…Although criticism [26][27][28] concerning the concept of depolarizing GABA has been largely invalidated in recent years [29][30][31][32][33] , supportive evidence from the intact mammalian brain is still lacking. In favour of a depolarizing GABA action in nonmammalian species in vivo, iontophoretic application of GABA or glycine was found to evoke somatic Ca 2 þ transients (CaTs) in spinal neurons of zebrafish larvae 34 .…”

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confidence: 99%

GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo

et al. 2015

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A large body of evidence from in vitro studies suggests that GABA is depolarizing during early postnatal development. However, the mode of GABA action in the intact developing brain is unknown. Here we examine the in vivo effects of GABA in cells of the upper cortical plate using a combination of electrophysiological and Ca 2 þ -imaging techniques. We report that at postnatal days (P) 3-4, GABA depolarizes the majority of immature neurons in the occipital cortex of anaesthetized mice. At the same time, GABA does not efficiently activate voltage-gated Ca 2 þ channels and fails to induce action potential firing. Blocking GABA A receptors disinhibits spontaneous network activity, whereas allosteric activation of GABA A receptors has the opposite effect. In summary, our data provide evidence that in vivo GABA acts as a depolarizing neurotransmitter imposing an inhibitory control on network activity in the neonatal (P3-4) neocortex.

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Excitatory actions of GABA in the intact neonatal rodent hippocampus in vitro

Cited by 68 publications

References 77 publications

Novel functions of GABA signaling in adult neurogenesis

Novel functions of GABA signaling in adult neurogenesis

Role of tonic GABAergic currents during pre- and early postnatal rodent development

GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo

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