EXCITATION study: Unexplained in-custody deaths: Evaluating biomarkers of stress and agitation

Vilke, Gary M.; Mash, Deborah C.; Pardo, Marta; Bozeman, William P.; Hall, Christine; Sloane, Christian; Wilson, Michael P.; Coyne, Christopher J.; Xie, Xiaobin; Castillo, Edward M.

doi:10.1016/j.jflm.2019.06.009

Cited by 10 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…OX1R has a high affinity for orexin-A, and OX2R has a similar affinity for both orexin-A and orexin-B. 18 A previous study 19 showed that orexin-A is elevated in the serum of patients with agitated delirium. Another recent study 20 showed that OX2R stimulation is associated with accelerated aggression in rodents.…”

Section: Discussionmentioning

confidence: 98%

Pilot Study of Lemborexant for Insomnia in Cancer Patients with Delirium

Terada¹,

Hirayama²,

Sadahiro³

et al. 2022

Journal of Palliative Medicine

View full text Add to dashboard Cite

Delirium occurs very frequently in cancer patients. Insomnia is a symptom of delirium. Lemborexant is a drug that regulates sleep–wake rhythms without causing extrapyramidal symptoms. Based on its ability to improve sleep, lemborexant is expected to have efficacy for insomnia with delirium. The purpose of this study was to determine the efficacy of lemborexant for insomnia in cancer patients with delirium. A retrospective observational study was conducted between July 2020 and February 2021. Fourteen patients (six females; mean age,69 years) were included. Lemborexant was effective in 11 of 14 (78.6%) patients. Of 14 patients, 10 had hyperactive delirium. Lemborexant might have similar efficacy for insomnia with and without delirium when compared with previous studies. The efficacy rate of lemborexant was 70% for patients with insomnia and hyperactive delirium. This study might lead to dose reductions of antipsychotic medications and fewer extrapyramidal symptoms in cancer patients with delirium.

show abstract

Section: Discussionmentioning

confidence: 98%

Pilot Study of Lemborexant for Insomnia in Cancer Patients with Delirium

Terada¹,

Hirayama²,

Sadahiro³

et al. 2022

Journal of Palliative Medicine

View full text Add to dashboard Cite

show abstract

“…In den letzten 36 Monaten registrierten wir 11 Damit ist der Weg zu vitalen Gefährdungen wie kardialer Dysfunktion, myokardialen Stressschäden, respiratorischer Insuffizienz und Rhabdomyolyse gebahnt [10]. Wird in diesem akut lebensbedrohlichen Zustand die Atmung durch eine Fixierung in Bauchlage behindert (▶ Abb.…”

Section: Eigene Beobachtungenunclassified

“…Typische Merkmale eines ExDS vom Notruf bis zu den Verlaufskomplikationen[5,9,10]. Therapeutisches Prozedereallgemeine Maßnahmen, Pharmakotherapie und ergänzende Schritte (nach Daten aus[5,6,14])…”

unclassified

Erregungssturm – Entstehung und Notfallbehandlung

Hölzle

Frank

Hörmann

et al. 2021

Dtsch Med Wochenschr

View full text Add to dashboard Cite

“…Even a recent study (cited within the 2021 report) uses “lack of tiring [or] unusual strength” as inclusion criteria for ExD. 30 However, Black individuals have long been stereotyped as possessing significant physical strength and stamina, especially when compared with White individuals. 31 – 33 Even when the actual strength of the subject is controlled for, Black men are perceived as stronger than White men.…”

Section: Introductionmentioning

confidence: 99%

Revisiting “Excited Delirium”: Does the Diagnosis Reflect and Promote Racial Bias?

Walsh

Agboola

Coupet

et al. 2023

WestJEM

View full text Add to dashboard Cite

Introduction: “Excited delirium” (ExD) is purported to represent a certain type of agitated state that can lead to unexpected death. The 2009 “White Paper Report on Excited Delirium Syndrome,” authored by the American College of Emergency Medicine (ACEP) Excited Delirium Task Force, continues to play a pivotal role in defining ExD. Since that report was produced, there has been an increasing appreciation that the label has been applied more often to Black people. Methods: Our aim was to analyze the language of the 2009 report, the role of potential stereotypes, and the mechanisms that may potentially encourage bias. Results: Our evaluation of the diagnostic criteria for ExD proposed in the 2009 report shows that it relies on persistent racial stereotypes: eg, unusual strength, decreased sensitivity to pain, and bizarre behavior. Research indicates that use of such stereotypes could encourage biased diagnosis and treatment. Conclusion: We suggest that the emergency medicine community avoid use of the concept ExD and that ACEP withdraw implicit or explicit support of the report.

show abstract

EXCITATION study: Unexplained in-custody deaths: Evaluating biomarkers of stress and agitation

Cited by 10 publications

References 41 publications

Pilot Study of Lemborexant for Insomnia in Cancer Patients with Delirium

Pilot Study of Lemborexant for Insomnia in Cancer Patients with Delirium

Erregungssturm – Entstehung und Notfallbehandlung

Revisiting “Excited Delirium”: Does the Diagnosis Reflect and Promote Racial Bias?

Contact Info

Product

Resources

About