Excitation-scanning hyperspectral video endoscopy: enhancing the light at the end of the tunnel

Abstract

Colorectal cancer is the 3rd leading cancer for incidence and mortality rates. Positive treatment outcomes have been associated with early detection; however, early stage lesions have limited contrast to surrounding mucosa. A potential technology to enhance early stagise detection is hyperspectral imaging (HSI). While HSI technologies have been previously utilized to detect colorectal cancer ex vivo or post-operation, they have been difficult to employ in real-time endoscopy scenarios. Here, we describe an LED-based multifurcated light guide and spectral light source that can provide illumination for spectral imaging at frame rates necessary for video-rate endoscopy. We also present an updated light source optical ray-tracing model that resulted in further optimization and provided a ∼10X light transmission increase compared to the initial prototype. Future work will iterate simulation and benchtop testing of the hyperspectral endoscopic system to achieve the goal of video-rate spectral endoscopy.

Switchable LED-based laparoscopic multispectral system for rapid high-resolution perfusion imaging

“…Light coupling into the fiber must be improved because SNR measurements indicated a slightly off-center illumination and low light intensities in the NIR range. Condensers, ray trace simulations to design optimized multi-branched light guides, 18 or alternative LED arrangements like a ring layout are methods of choice. For the latter, it was recommended to use multiple LEDs of each wavelength 19 .…”

Ontology-Based Architecture Process of System-of-Systems: From Capability Development to Operational Modeling

“…SysML furnishes a user-friendly graphical syntax, exemplified by the Block Definition Diagram (BDD) that models system concepts and relationships [34], as well as the Internal Block Diagram (IBD) that illustrates intricate system architecture and component interconnections [35]. Nevertheless, it is notable that the language is deficient in formal semantics [36].…”

Adaptive denoising hyperspectral data for visualization enhancement of intraoperative tissue

“…With the continuous advancement in acquisition techniques such as miniaturizing hardware footprint and shortening acquisition time, the capturing and analysis of HSI data have been successfully widened their applications into neurology, dermatology, gastroenterology and ophthalmology and bronchoscopy, and so on. [6][7][8][9][10][11] The availability of hyperspectral datacube increased the sensitivity of instrumentally probing human tissue's abnormalities such as blood perfusion, malignant proliferation of cancerous cells and so on. However, the captured spectral data were often degraded by the perturbations caused by every factor involved within a whole imaging chain.…”

“…With the continuous advancement in acquisition techniques such as miniaturizing hardware footprint and shortening acquisition time, the capturing and analysis of HSI data have been successfully widened their applications into neurology, dermatology, gastroenterology and ophthalmology and bronchoscopy, and so on. [6–11]…”