The results of a series of experiments on the interaction of 12 C and 16 O with medium and heavy nuclei ( 59 Co, 93 Nb, 103 Rh, 197 Au), in which the spectra of intermediate mass fragments and the excitation functions for production of a large number of evaporation residues have been measured up to 400 MeV incident energy, are reviewed. The scopes of these experiments were to get a comprehensive information on the reactions which may occur and to develop a model which might reproduce all the measured data within a unique global calculation. This was indeed found to be possible considering the complete fusion of the two interacting ions, the binary fragmentation of the projectile followed by the fusion of one of the fragments with the target nucleus, and the projectile inelastic scattering. The theoretical models which allow to reproduce the data, i.e., the fragmentation model and the Boltzmann Master Equation theory which describes nuclear thermalization are briefly summarized.