Excitation functions of (p, 2n) and (p, pn) reactions and differential and integral yields of 123I in proton induced nuclear reactions on highly enriched 124Xe

Radionuclide Generators

“…Teams of researchers from Canada, Russia, Germany, Hungary, the United States, Saudi Arabia and Holland [103 -110] reported detailed measurements of the excitation functions for proton induced nuclear reactions on highly enriched 124 Xe targets. The experimentally determined yields and theoretical yield data of [110] are consistent within 15%, but lower by a factor of 2 than experimental literature values [107,109]. The reasons for the discrepancy remain controversial.…”

“…The In(p,xn) n0 In and the ,,0 Cd( 3 He,3n) ll0 Sn nuclear reactions have been studied [97,98], Rösch et al [98] experimentally determined the yield of 110 Sn (T U2 = 4.1 h) produced by the "°Cd( 3 He,3n) 110 Sn reaction with 3 He of 35 to 18 MeV. Their data extrapolated to 100% isotopie enrichment of ,,0 Cd gave a production rate of 75±4 MBq · μΑΙι" 1 .…”

“…Their data extrapolated to 100% isotopie enrichment of ,,0 Cd gave a production rate of 75±4 MBq · μΑΙι" 1 . A thermochromatographic separation of no-carrier-added 110 Sn in 90% yield was achieved in <0.5 h from 200 mg Cd or CdO by using Cl 2 gas flowing at 15 ml · min" 1 at r max = 800°C. The l10 Sn was washed from the quartz collection tube with dilute HCl, and adsorbed onto a silica gel column (2 mmX40 mm).…”

The present and future of medical radionuclide production

“…The chemical form of the product coming out of the target depends on the composition of the target gas and the accumulated radiation dose. Thus precursors for labelling work with 11 18 F can now be produced in quantities up to 100 GBq per target batch.…”

“…For in vivo diagnostic investigations involving organ imaging, for example, radionuclides are required that can be efficiently detected from outside of the body. To this end, short-lived γ -ray emitters, like 99m Tc and 123 I, and positron emitters, like 11 C and 18 F, are commonly used, the former finding application in Single Photon Emission Computed Tomography (SPECT) and the latter in Positron Emission Tomography (PET). The underlying principle in diagnostic nuclear medicine is that the radiation dose to the patient is as low as possible, compatible with the required quality of imaging and the diagnostic advantage in comparison to non-radioactive methods.…”