Excitation Functions for ^natW(p,xn)^181-186Re Reactions and Production of No-Carrier-Added ¹⁸⁶Re via 186W(p,n) 186Re Reaction

Abstract

Excitation functions were measured for the formation of l81 Re, 182m Re, 1828 Re, 183 Re, 184m Re, ,84e Re and 186 Re in proton-induced reactions on natural tungsten in the energy range of 7.5-22.5 MeV. The excitation function for 186 W(p,n)' 86 Re reaction has been obtained with maximum cross section value of 41.6 ± 6.2 mb at the proton energy of 9.2 MeV. 186 Re was produced from the reaction induced by 16 MeV protons on isotopically enriched 186 W metal powder target. Following the separation from 187 W, 183 Ta and the bulk of target material ,86 W through an acid alumina column, 186 Re was concentrated and purified by an anion exchange column, and finally the no-carrier-added 186 Re saline solution was achieved. The radionuclidic purity of ,86 Re was > 99.2%. The experimental thick-target yield of l86 Re was determined to be approximately 50 μΟ/μΑΪι, in good agreement with that estimated from the excitation function.

Excitation functions and yields for cyclotron production of radiorheniumvianatW(p,ߙxn)181-186gRe nuclear reactions and tests on the production of186gRe using enriched186W

“…(5) [16]. It is clear that now the thick-target count rates fit the corrected summation of the thin-target yields, not only for our results but also for the data of Zhang et al [17], and even with small error to that of Moustapha et al [29]. However, Fig.…”

“…Recently a critical evaluation of the existing data was done using extensive nuclear model calculations by Hussain et al [9]. Besides pointing out many discrepancies in the data [2,[10][11][12][13][14][15][16][17], it was concluded that the use of highly enriched 186 W target material is absolutely necessary to produce high-purity 186g Re via the 186 W( p, n)-reaction, and that the energy of protons should be < 18 MeV [9].…”

Evaluation of charged particle induced reaction cross section data for production of the important therapeutic radionuclide186Re

“…Zhang et al [18] reported eight cross section values between 7 and 18 MeV. The beam monitor reactions used were the 63 Cu( p, 2n) 62 Zn and 65 Cu( p, n) 65 Zn processes and the data were taken from Grütter [51].…”

Deuteron irradiation of W and WO3 for production of high specific activity 186Re: Challenges associated with thick target preparation

“…These reactions result in much higher specific activities, as the 186 Re is produced from a different element that can be chemically separated post-irradiation. Previously published investigations of high specific activity 186 Re production have utilized the 186 W(p,n) 186 Re or 186 W(d,2n) 186 Re reactions (Alekseev and Lazarev, 2006;Bonardi et al, 2010;Fassbender et al, 2013;Shigeta et al, 1996;Zhang et al, 2001;Zhang et al, 1999). It was concluded from those investigations that activation of 186 W by deuterons was preferred over protons as: (1) production yields are at least three time higher (Zhang et al, 2001), (2) the 186 Re radionuclidic purity is higher and remains higher (Alekseev and Lazarev, 2006;Zhu et al, 1997), and (3) lower quantities of enriched 186 W material are required for the irradiations.…”

“…The overall goal of this investigation was to demonstrate that production-levels of high specific activity 186 Re can be obtained via the (d,2n) reaction using thick W targets. Prior reported studies have used a variety of target materials for production of 186 Re, including W metal (Bonardi et al, 2010;Zhang et al, 2001;Zhang et al, 1999), WO 3 (Fassbender et al, 2013;Moustapha et al, 2006;Shigeta et al, 1996), Al 2 (WO 4 ) 3 (Zhu et al, 1997), and W carbides (Richards et al, 2015). However, those studies were limited to "thin" target bombardments or thick target investigations using only natural abundance target 3 material.…”