Excitation function for deuteron induced nuclear reactions on natural ytterbium for production of high specific activity 177gLu in no-carrier-added form for metabolic radiotherapy

Investigation of (d,x) nuclear reactions on natural ytterbium up to 24MeV

“…The measured cross-sections of 169g Lu, presented in Fig. 1, show a consistency with the earlier measurements by Manenti et al [8] and Tarkanyi et al [15]. The TENDL-2013 library [54] shows a systematically larger production cross-section than the experiments, especially at higher energies.…”

“…A general survey of the literature reveals that only four earlier investigations [7,8,15,31] were carried out for the production of aforementioned medically and technologically important radionuclides via deuteron irradiations on natural ytterbium targets, but discrepancies are found among the reported data. Therefore, further experimental data are required to reduce the discrepancies and also to complement the data needed to optimize the production of medically important radionuclides.…”

“…It can be alloyed with stainless steel to improve some of its mechanical properties [1], used as a doping agent in fibre optic cables [2], in making lasers [3], in ceramic industry [4], in dentistry [5], and used for the production of medically and technologically important radionuclides [6][7][8][9][10]. Therefore, an accurate knowledge of activation cross-sections of ytterbium isotopes is indispensable for various practical applications in science and technology.…”

“…177 Lu routes followed by a complex separation procedure of 177 Lu from the Yb isotopes [14]. On the other hand, the carrier-free 177 Lu is available in the charged-particle irradiations on various targets, though its activity is relatively lower than those in the reactor productions [6][7][8][15][16][17]. However, it may be possible to overcome this deficiency with recent high-power accelerator technologies, which enable large scale and on-site productions of 177 Lu leading to its various practical applications.…”

Ion and Neutron Beams Discover New Facts from History

“…For indirect production paths the final product populated by (n,γ)b -is also accessible directly by (d,n) reactions. The excitation functions for 176 Yb(d,p) and 176 Yb(d,n) were recently measured [Man11]. Even if 0.1 mA of deuteron current is sustained over one week on a highly enriched metallic 176 Yb target, only about 80 GBq of 177 Lu would be produced.…”