Excitation-Contraction Coupling in Skeletal Muscle

Heiny, Judith A.

doi:10.1016/b978-0-08-057455-4.50073-6

Cited by 126 publications

(1 citation statement)

References 63 publications

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“…The depolarization of the surface membrane of muscle cell initiated by the nerve impulse (Sperelakis & Gonzales-Serratos, 2001;Wahler, 2001) is conducted into the interior of the muscle fiber by extensions of the surface membrane called the transverse (T) tubules (Heiny, 2001). The T tubules establish specialized contacts (T-SR junctions, triads, diads) with the junctional membrane of SR, that contain the two key components of the excitation-contraction coupling apparatus, the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR) (Franzini-Armstrong, 1999).…”

Section: Excitation-contraction (E-c) Coupling the Ca 2+ Release Chamentioning

confidence: 99%

The network of calcium regulation in muscle.

Martonosi

Pikula²

2003

Acta Biochim Pol

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In this review the molecular characteristics and reaction mechanisms of different Ca(2+) transport systems associated with various membranes in muscle cells will be summarized. The following topics will be discussed in detail: a brief history of early observations concerning maintenance and regulation of cellular Ca(2+) homeostasis, characterization of the Ca(2+) pumps residing in plasma membranes and sarco(endo)plasmic reticulum, mitochondrial Ca(2+) transport, Ca(2+)-binding proteins, coordinated expression of Ca(2+) transport systems, a general background of muscle excitation-contraction coupling with emphasis to the calcium release channels of plasma membrane and sarcoplasmic reticulum, the structure and function of dihydropyridine and ryanodine receptors of skeletal and cardiac muscles, and finally their disposition in various types of muscles.

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Section: Excitation-contraction (E-c) Coupling the Ca 2+ Release Chamentioning

confidence: 99%

The network of calcium regulation in muscle.

Martonosi

Pikula²

2003

Acta Biochim Pol

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Stimulus-permeability coupling in rat pulmonary macrophages challenged by Pseudomonas aeruginosa

et al. 1985

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Electron probe X-ray microanalysis (XRMA) of freeze-dried ultrathin sections provides the capability of measuring intracellular elemental content. This methodology was used to investigate the stimulus-permeability coupling responses associated with phagocytosis of Pseudomonas aeruginosa by cultured pulmonary alveolar macrophages (PAMs) of rats. PAMs were challenged with P. aeruginosa suspended in Gey's buffer at a bacteria to PAM ratio of 50:1 for 1 h at 37 degrees C. A 1-mm3 pellet of the unchallenged control PAMs, challenged PAMs and P. aeruginosa alone was quench-frozen in nitrogen-cooled, liquid propane, and 0.1-micron cryosections were cut at -100 degrees C. X-ray spectra were collected for nucleus and cytoplasm of 39 control PAMs, 36 challenged PAMs and 40 P. aeruginosa. Concentrations (mmole/kg dry weight) were obtained for Na, Cl, K, Ca, Mg, P, S for each cell. In the control PAMs, the content was similar to other mammalian cells. Moreover, there were no differences in elemental content between nucleus an cytoplasm. In the challenged PAMs, Na concentration was 4 times that of control PAMs (p less than 0.001) whereas Cl was double (p less than 0.001), K was 29% lower (p less than 0.001), and Ca was 4 times higher (p less than 0.05). The elemental concentration profile in the P. aeruginosa was distinctly different from that of the PAMs: higher Na, Ca, Mg, but lower Cl and K values. These results demonstrated elemental content changes in cultured PAMs challenged with P. aeruginosa that indicate a stimulus-permeability response by membranes associated with the phagocytic process.

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Microtubule-associated smooth endoplasmic reticulum in the frog's brain

Lieberman

1971

Z. Zellforsch.

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Excitation-Contraction Coupling in Skeletal Muscle

Cited by 126 publications

References 63 publications

The network of calcium regulation in muscle.

The network of calcium regulation in muscle.

Stimulus-permeability coupling in rat pulmonary macrophages challenged by Pseudomonas aeruginosa

Microtubule-associated smooth endoplasmic reticulum in the frog's brain

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