A 35-yr-old male was examined in the outpatient clinic of the present authors' department. He complained of a dry paroxysmal cough of indeterminate origin that he had noticed 3 months earlier. The cough was associated with a tickling feeling in the throat. There was no association between coughing flares and meals, nasal discharge, season, time of day or body posture. The patient did not recall having symptoms compatible with an upper airway viral infection in the past 3 months and reported no gastro-intestinal symptoms like daily heartburn and regurgitation. He lived in the city, was a lifetime nonsmoker, his previous medical history was unremarkable and he was not taking any medication. He worked as an electronic engineer in a smoke-and dust-free environment and exhibited a type A personality. Upon appearance of the cough 3 months earlier, he had been examined by a physician and had A thorough physical examination and routine laboratory tests, including white blood cell count and differential, red blood cell count, erythrocyte sedimentation rate, liver and renal function tests, serum C-reactive protein and an ECG were normal. Chest ( fig. 1) and paranasal sinus (image not shown) radiographs were taken. Ear, nose and throat assessment was unremarkable. After discontinuing treatment with inhaled salmeterol and fluticasone, simple spirometry pre-and post-bronchodilator (four puffs of 100 mg salbutamol) and bronchoprovocation challenge with methacholine were performed ( fig. 2). The patient was given a peak flow meter and during a monthly observation period his diurnal peak flow variation was below 5% (data not shown).