Excision Biopsy of Peripheral Lymphadenopathy in Children in a Community Hospital

Al-Nazer, Mona; Al-Salem, Ahmed H.

doi:10.5144/0256-4947.2003.410

Cited by 5 publications

(13 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, most of the infectious cases (57.4%) had a duration of symptoms of less than 1 month, while most of the noninfectious ones (48%) had a duration of symptoms of between 1 and 6 months, which was statistically significant. This correlation, however, is not supported in several previous studies [20,22,31]. Most of the infectious cases in our study presented with localized lymphadenopathy, while most of the noninfectious cases presented with generalized lymphadenopathy, which was statistically significant.…”

Section: Discussioncontrasting

confidence: 99%

“…There was a significant difference regarding LN size between the nonneoplastic and neoplastic categories in this study, whereby a LN greater than 2 cm in diameter was considered clinically significant. This is in accordance with the results of other studies [19–22]; the study by Oguz and colleagues [22] reported a maximum diameter of more than 2 cm as the appropriate limit with which to distinguish malignant or granulomatous diseases from others. The study by Al-Nazer and Al-Salem [20] observed that only 8% of reactive hyperplasia had a LN diameter of more than 2 cm, while all those with a specific diagnosis had LNs with a maximum diameter greater than 2 cm.…”

Section: Discussionsupporting

confidence: 92%

“…This is in accordance with the results of other studies [19–22]; the study by Oguz and colleagues [22] reported a maximum diameter of more than 2 cm as the appropriate limit with which to distinguish malignant or granulomatous diseases from others. The study by Al-Nazer and Al-Salem [20] observed that only 8% of reactive hyperplasia had a LN diameter of more than 2 cm, while all those with a specific diagnosis had LNs with a maximum diameter greater than 2 cm. Thus, a LN size of 2 cm can be considered an appropriate limit with which to distinguish those with specific diagnosis from those with reactive hyperplasia.…”

Section: Discussionsupporting

confidence: 92%

See 2 more Smart Citations

Lymphadenopathy in a Series of Egyptian Pediatric Patients and the Role of Pathology in the Diagnostic Workup

et al. 2014

View full text Add to dashboard Cite

Assessment of lymphadenopathy in children represents a diagnostic challenge because of the extensive differential diagnoses, including reactive and malignant conditions. Knowledge of the etiologic pattern of lymphadenopathy in a given geographical region is essential for making a confident diagnosis or for suspecting a disease. Hence, the present study was carried out to identify different etiologies of lymphadenopathy in children in our region and to assess parameters commonly associated with malignancy, with an emphasis on the role of pathology. One hundred and twenty patients aged 1 month to 18 years were included in the study. They were sorted into neoplastic and nonneoplastic (infectious and noninfectious) groups. In 56 patients, biopsy (fine needle aspiration cytology [FNAC], core needle, or excision biopsy) was essential to reach the final diagnosis. Sensitivity of FNAC in the differentiation between neoplastic and nonneoplastic lymphadenopathy was 92.3%, and specificity was 90.0%, with a diagnostic accuracy of 91.3%. We concluded that malignancy should be suspected in the following conditions: presence of abdominal or multiple symptoms; symptom duration of 1-6 months; generalized lymphadenopathy; multiple groups of lymph node (LN) involved; LN size > 2 cm; amalgamated, hard, fixed, and nontender LNs; certain abnormal complete blood count findings; blast cells in blood film; and elevated lactate dehydrogenase level. In such cases, LN biopsy is highly recommended. A final diagnosis was achieved after integrating information from history and clinical findings with the laboratory, radiological, pathological, and microbiological findings. Accordingly, an algorithm for primary diagnostic evaluation of children with lymphadenopathy is suggested.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Lymphadenopathy in a Series of Egyptian Pediatric Patients and the Role of Pathology in the Diagnostic Workup

et al. 2014

View full text Add to dashboard Cite

show abstract

“…[12] This also corresponds to the greater exposure in this age group to other children in school and play settings, with increased frequency of upper respiratory tract and ear infections. [13] Our study was consistent with this pattern, with an overall mean age of 8 years. Although children with tuberculosis had an older mean age at presentation, while those with reactive hyperplasia presented at a younger age, this difference was not found to be statistically significant.…”

Section: Discussionsupporting

confidence: 89%

Lymph node biopsy in children: Indications and etiology

Aftab

Hasan

Samad

2020

J Pediatr Adolesc Surg

View full text Add to dashboard Cite

Background: Peripheral lymphadenopathy manifests in a variety of benign and malignant conditions and is often challenging to distinguish pathologic from non-pathologic etiology based on clinical presentation alone. Therefore, lymph node biopsy is often required as an essential part of management. This study aimed to determine the causes of peripheral lymphadenopathy in children needing excision biopsy in our setting and establish a correlation with clinical features and laboratory findings. Methods: A retrospective review of medical records of children aged 0-14 years undergoing lymph node biopsy at our institution, between January 2015 and June 2018, was conducted. Demographic, microbiological, and histopathological findings were reviewed. Results: A total of 69 patients underwent lymph node biopsy, the majority of whom were male (n=40, 58%), with a mean age of 7.9 years. The histopathological findings confirmed lymphoma (n=27), tuberculosis (n=24), benign reactive changes (n=14), and Langerhan Cell Histiocytosis (n=4). Cervical lymph nodes were most frequently involved (n=64). Associated symptoms included fever (n= 27), weight loss (n=2) and cough (n=7). Only one patient developed a postoperative complication (wound infection). A clinical diagnosis of tuberculosis (TB) had been presumed in 19 patients, but only 2 (11%) were confirmed to have TB, whereas10 were found to have histopathological findings of lymphoma. Conclusion: Excisional biopsy is useful in the management of children with lymphadenopathy, allowing treatment to be initiated based on a histopathological diagnosis.

show abstract

“…Histologically lymph nodes showed partial architectural effacement by large discrete areas of necrosis with abundant nuclear debris surrounded by lymphocytes, histiocytes and plasmacytoid monocytes. (15) Castleman disease also called angiofollicular lymphoid hyperplasia. Histologically these cases show partial effacement of lymph node architecture by large follicles having atrophic germinal centres.…”

Section: Resultsmentioning

confidence: 99%

Study of Clinico-pathological Spectrum of Lymphadenopathy

Sunita¹

2018

jmscr

View full text Add to dashboard Cite

Excision Biopsy of Peripheral Lymphadenopathy in Children in a Community Hospital

Cited by 5 publications

References 6 publications

Lymphadenopathy in a Series of Egyptian Pediatric Patients and the Role of Pathology in the Diagnostic Workup

Lymphadenopathy in a Series of Egyptian Pediatric Patients and the Role of Pathology in the Diagnostic Workup

Lymph node biopsy in children: Indications and etiology

Study of Clinico-pathological Spectrum of Lymphadenopathy

Contact Info

Product

Resources

About