Excimer laser tissue interactions in the cornea

Vinciguerra, Riccardo; Borgia, Alfredo; Tredici, Costanza; Vinciguerra, Paolo

doi:10.1016/j.exer.2021.108537

Cited by 4 publications

(5 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The process of corneal epithelial wound healing involves various growth factors, cytokines, and cell-signaling events. Gene therapy has been used to deliver target genes in diabetic corneas with slow epithelial wound healing [ 141 , 143 ]. Overexpression of c-Met, a gene involved in wound-healing-related processes, has been found to normalize diabetic markers and stimulate wound healing [ 144 ].…”

Section: Gene Therapiesmentioning

confidence: 99%

Ocular-Surface Regeneration Therapies for Eye Disorders: The State of the Art

Posarelli

Romano

Tucci

et al. 2023

BioTech

Self Cite

View full text Add to dashboard Cite

The ocular surface is a complex structure that includes cornea, conjunctiva, limbus, and tear film, and is critical for maintaining visual function. When the ocular-surface integrity is altered by a disease, conventional therapies usually rely on topical drops or tissue replacement with more invasive procedures, such as corneal transplants. However, in the last years, regeneration therapies have emerged as a promising approach to repair the damaged ocular surface by stimulating cell proliferation and restoring the eye homeostasis and function. This article reviews the different strategies employed in ocular-surface regeneration, including cell-based therapies, growth-factor-based therapies, and tissue-engineering approaches. Dry eye and neurotrophic keratopathy diseases can be treated with nerve-growth factors to stimulate the limbal stem-cell proliferation and the corneal nerve regeneration, whereas conjunctival autograft or amniotic membrane are used in subjects with corneal limbus dysfunction, such as limbal stem-cell deficiency or pterygium. Further, new therapies are available for patients with corneal endothelium diseases to promote the expansion and migration of cells without the need of corneal keratoplasty. Finally, gene therapy is a promising new frontier of regeneration medicine that can modify the gene expression and, potentially, restore the corneal transparency by reducing fibrosis and neovascularization, as well as by stimulating stem-cell proliferation and tissue regeneration.

show abstract

Section: Gene Therapiesmentioning

confidence: 99%

Ocular-Surface Regeneration Therapies for Eye Disorders: The State of the Art

Posarelli

Romano

Tucci

et al. 2023

BioTech

Self Cite

View full text Add to dashboard Cite

show abstract

“…A steeper cornea, rather than a flatter one, will reflect mires that are thinner and more tightly spaced; additionally, mires in the steep area are nearer to the center. An irregular surface reflects distorted and irregular mires [36].…”

Section: Keratoscopymentioning

confidence: 99%

“…In cases of initial diastasis, there is typically correspondence between localised pachymetric thinning, increased posterior elevation, and a possible increase in the anterior elevation at the same location. While in cases of focal endothelial dysfunction or in the case of increased tissue apposition (corneal epithelium) at the donor-recipient junction, due to the high corneal curvature gradient [36], there will be a pachymetric increase without the associated posterior elevation at the same point. The use of epithelial maps and the analysis of the corneal surface via slit lamp often help in differentiating the last two conditions [51].…”

Section: Scheimpflug Photography (Tomography)mentioning

confidence: 99%

“…It was discovered that variations in the epithelial thickness profile are very predictable, reacting to alterations in the gradient of the stromal curvature. Since the epithelia partially hide stromal surface irregularities [36,65], adaptive epithelial thickness alterations are thus a crucial component of the diagnosis of irregular astigmatism [66]. The epithelial thickness map can represent an additional tool in the evaluation of irregular astigmatism post-keratoplasty.…”

Section: Corneal Epithelial Mappingmentioning

confidence: 99%

See 1 more Smart Citation

Managing Post-Keratoplasty Astigmatism: High-Tech vs. Low-Tech Imaging Techniques for Guiding Suture Manipulation

Borgia

Romano

et al. 2023

JCM

Self Cite

View full text Add to dashboard Cite

Astigmatism is a visually significant condition that can develop after keratoplasty. The management of post-keratoplasty astigmatism can be performed both when transplant sutures are in place and when they have been removed. Fundamental for astigmatism management is its identification and characterization in terms of type, amount, and direction. Commonly, post-keratoplasty astigmatism is evaluated through corneal tomography or topo-aberrometry; however, many other techniques can be used in case these instruments are not readily available. Here, we describe several low-tech and high-tech techniques used for post-keratoplasty astigmatism detection in order to quickly understand if it contributes to low vision quality and to determine its characteristics. The management of post-keratoplasty astigmatism through suture manipulation is also described.

show abstract

“…This wavelength is absorbed by corneal proteins and its photon energy breaks molecular bonds resulting in photoablation 56 . The initial patent for using excimer laser in correcting refraction was introduced by Peyman 1989 59 . The excimer laser can ablate the cornea in a depth of 300 m and offers the advantage of sharply delineated surgical wounds with only little heat transfer and mutation risk 56 .…”

Section: Applications Of Laser In Corneal Surgerymentioning

confidence: 99%

Advanced surgeries, medicines and materials for corneal regeneration

Xeroudaki

2022

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Excimer laser tissue interactions in the cornea

Cited by 4 publications

References 73 publications

Ocular-Surface Regeneration Therapies for Eye Disorders: The State of the Art

Ocular-Surface Regeneration Therapies for Eye Disorders: The State of the Art

Managing Post-Keratoplasty Astigmatism: High-Tech vs. Low-Tech Imaging Techniques for Guiding Suture Manipulation

Advanced surgeries, medicines and materials for corneal regeneration

Contact Info

Product

Resources

About