Exchangeable body potassium and sodium in patients in congestive heart failure

Flear, C. T. G.; Quinton, Ann; Carpenter, R. G.; Domenet, J. G.; Sivyer, A.

doi:10.1016/0009-8981(66)90258-0

Cited by 23 publications

(16 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results for K, agree with those of other workers in showing a decrease in heart failure (Flear et al, 1966). In this study the Ke/DBW ratio increased significantly with recovery from heart failure to a value approximating closely to that in the control group.…”

Section: Recoveredñsupporting

confidence: 95%

“…In patients free of oedema, results have varied : Carroll, Gotterer & Altshuler (1965) found an increase in exchangeable sodium, whereas Lockey, Longmore, Ross & Sturridge (1966) and Oleson (1966) found no significant increase. Flear, Quinton, Carpenter, Domenet & Sivyer (1966) and Lockey et al (1966) have reported a significant depletion of total exchangeable potassium in patients with cardiac failure.…”

mentioning

confidence: 96%

See 1 more Smart Citation

Potassium and Sodium Distribution in Cardiac Failure

Cox¹,

Horrocks²,

Speight³

et al. 1971

Clinical Science

View full text Add to dashboard Cite

1. Total body water, extracellular fluid, total exchangeable potassium and total exchangeable sodium were measured by the multiple isotope-dilution technique in eight patients with congestive cardiac failure. Measurements were made on each patient while in failure and then again after treatment and recovery.2. Compared with five control subjects in whom the same measurements were made, patients in failure had an excess of total body water, extracellular fluid and total exchangeable sodium, and had less total exchangeable potassium.3. There was a decrease in total exchangeable sodium and an increase in total exchangeable potassium on recovery from congestive cardiac failure.4. After treatment of cardiac failure, intracellular potassium increased and intracellular sodium was decreased. 5. The low total exchangeable potassium in cardiac failure is not simply due to loss of lean body mass.

show abstract

Section: Recoveredñsupporting

confidence: 95%

mentioning

confidence: 96%

Potassium and Sodium Distribution in Cardiac Failure

Cox¹,

Horrocks²,

Speight³

et al. 1971

Clinical Science

View full text Add to dashboard Cite

show abstract

“…Despite these changes in the urine Na/K ratio and in plasma potassium, no significant change in KE was seen after treatment with either amiloride or spironolactone. Values for KE were usually within the reported normal range (Flear et al, 1966) …”

Section: Generalmentioning

confidence: 85%

Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure.

Nicholls¹,

Espiner²,

Hughes³

et al. 1976

Heart

View full text Add to dashboard Cite

The renin-angiotensin-aldosterone system and electrolyte levels in 11 patients with heartfailure controlled on digoxin and frusemide were investigated after separate periods of Slow K, spironolactone, and amiloride therapy. When spironolactone or amiloride replaced Slow K, distinct parallel increments in the levels of renin, angiotensin II, and aldosterone resulted. Though plasma potassium was generally higher after spironolactone and amiloride than after Slow K, exchangeable potassium was similar with the three regimens. There was no significant relation between plasma potassium and concurrent exchangeable potassium.

show abstract

“…1954; Moore et al, 1954;Wilson et al, 1954;Birkenfeld et al, 1958;Deuxchaisnes et al, 1961;Flear et al, 1966;Singh, Hurley and North, 1969;White et al, 1969;Cox et al, 1971;Croxson, Neutze and John, 1972). For the subsequent, more detailed analyses, the authors collated all the published values they could find for exchangeable potassium in healthy persons and patients with heart failure, where the individual's sex, age and weight were available as well as the exchangeable potassium.…”

Section: Methodsmentioning

confidence: 99%

“…Height was noted if it had been measured, and for each patient with heart failure it was noted whether the patient was oedematous and if he was taking diuretics alone or with potassium supplements. Details were collected of 345 healthy controls (Corsa et al, 1950;Aikawa et al, 1952;Deane and Smith, 1952;Arons, Vanderlinde and Solomon, 1954;Blainey et al, 1954;Moore et al, 1954;Wilson et al, 1954;Ikkos et al, 1955;Sagild, 1956;Ljunggren, Ikkos and Luft, 1957;Birkenfeld et al, 1958;Crookes, Bluhm and Muldowney, 1959;MacGillivray, Buchanan and Billewicz, 1960;Talso et al, 1960;Deuxchaisnes et al, 1961;Singh et al, 1969;Cox et al, 1971;Skrabal, Arnot and Joplin, 1973); and 333 patients with heart disease (Aikawa et al, 1952;Blainey et al, 1954;Moore et al, 1954;Wilson et al, 1954;Aikawa and Fitz, 1956;Birkenfeld et al, 1958;Deuxchaisnes et al, 1961;Olesen, 1964;Carroll, Gotterer and Altshuler, 1965;Flear et al, 1966;Olesen, 1968;Singh et al, 1969;White et al, 1969;Cox et al, 1971;Croxson et al, 1972;Davidson and Gillebrand, 1974;Olesen and Valentine, 1973).…”

Section: Methodsmentioning

confidence: 99%

Potassium depletion in heart failure and its relation to long-term treatment with diuretics: a review of the literature

Morgan

Burkinshaw

Davidson

1978

Postgraduate Medical Journal

View full text Add to dashboard Cite

SummaryThere have been many studies which suggest that patients with heart failure were potassium depleted. This depletion has been attributed to the use of potent diuretics, and these are now given with either potassium supplements or potassium-retaining diuretics. A detailed examination of the studies suggests that the reported decrease in body potassium compared with the results in healthy persons is not due to the diuretics. It can be partly explained by a failure to match patients and controls in terms of age, and the remaining difference can be explained by muscle wasting. There is therefore no evidence of a potassium depletion in these patients with heart failure.

show abstract

Exchangeable body potassium and sodium in patients in congestive heart failure

Cited by 23 publications

References 4 publications

Potassium and Sodium Distribution in Cardiac Failure

Potassium and Sodium Distribution in Cardiac Failure

Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure.

Potassium depletion in heart failure and its relation to long-term treatment with diuretics: a review of the literature

Contact Info

Product

Resources

About