Exchange Grafts in Vitiligo

Spencer, Gerald A.; Tolmach, Jesse A.

doi:10.1038/jid.1952.59

Cited by 46 publications

(12 citation statements)

References 8 publications

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“…Spencer [624] observed that full-thickness grafts in a black patient retained their pigment for five months, but the vitiliginous skin grafted to a normal area remained depigmented except for a slight repigmentation at the periphery. Similar results were observed by Spencer and Tolmach [625] 16 months after grafts were performed. Orentreich [626] did transposition experiments with full-thickness grafts in two white women who were followed for more than one year.…”

Section: Grafting Experiments Reflecting Neurologic Environmentsupporting

confidence: 89%

Vitiligo and Other Hypomelanoses of Hair and Skin

Ortonne¹,

Mosher²,

Fitzpatrick³

1983

139

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Section: Grafting Experiments Reflecting Neurologic Environmentsupporting

confidence: 89%

Vitiligo and Other Hypomelanoses of Hair and Skin

Ortonne¹,

Mosher²,

Fitzpatrick³

1983

139

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“…The results of studies on exchange grafts in vitiligo [8], involving the transplantation of full-thickness normal pigmented skin to vitiliginous areas and vice versa, have shown that pigment-free skin transplanted to a normal site does not become pigmented while, in contrast, normal skin remains pigmented. Furthermore, α-melanocyte stimulating hormone (α-MSH) injected intradermally into the centre of vitiliginous skin and intramuscularly does not result in hyperpigmentation in involved skin [9].…”

Section: Introductionmentioning

confidence: 99%

The occurrence of cutaneous nerve endings and neuropeptides in vitiligo vulgaris: a case-control study

et al. 1996

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Pioneering studies both in humans and animals have demonstrated an association between the peripheral nervous system and epidermal melanocyte destruction. The presence of certain neuropeptides and neuronal structural markers in peripheral nerve fibres was investigated in involved and uninvolved vitiligo skin and compared with normal healthy skin. A group of 18 vitiligo vulgaris patients and matched healthy volunteers participated in the investigation. The indirect immunofluorescence technique was employed. There was a tendency for a reduction in the number and intensity of low affinity (p75) nerve growth factor receptor immunoreactive (NGFr-IR) basal keratinocytes in involved vitiliginous skin (P < 0.06) compared with control skin, while the number of NGFr-IR nerve fibres was significantly increased (P < 0.01). The number of calcitonin gene-related peptide (CGRP)-IR nerve fibres in the epidermis and papillary dermis was dramatically increased in involved skin as compared with control skin (P < 0.01) and with uninvolved skin (P < 0.05). No clear difference could be found in the distribution of vasoactive intestinal polypeptide (VIP)- and neuropeptide tyrosine (NPY)-IR nerve fibres. A different structural appearance of the peripheral nervous system as well as a changed balance of neuropeptides in vitiliginous skin point to a critical role of the nervous system in the pathogenesis of vitiligo.

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“…Therefore, the only treatment for depigmentation caused by second‐ and third‐degree burns is by means of skin autografts. Repigmentation by autografts has been reported in cases of vitiligo 6–9 . Bonafe and associates 9 stressed that the grafts must be complete with hair follicles in the treatment of vitiligo.…”

Section: Discussionmentioning

confidence: 99%