Excessive zinc in diet induces leptin resistance in Wistar rat through increased uptake of nutrients at intestinal level

Taneja, Satish Kumar; Jain, Manjari; Mandal, Reshu; Megha, Kirti

doi:10.1016/j.jtemb.2012.03.002

Cited by 18 publications

(8 citation statements)

References 32 publications

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“…Leptin resistance appears when threshold level of serum leptin above which its increase does not translate into proportional increase in cerebrospinal fluid or brain leptin level [37]. This in turn may result in apparent leptin resistance leading to increase in food intake and higher gain in body weight as observed in subgroups-II and III also reported previously [14], and subgroups-IICE and IIICE respectively in the present study. In contrast, the leptin level in subgroup-IIME and IIIME were evaluated significantly less than those of Zn-HL-diet and CE mixed diet fed groups suggesting that the ME in Zn rich diet did not allow developing leptin resistance as manifested in term of lesser food intake and lesser gain in body weight.…”

Section: Discussionsupporting

confidence: 70%

“…They were used in this study after taking approval of the protocol from Institutional Ethics Committee. $ Semi-synthetic basal diet was employed with increasing Zn concentration to induce hyperleptinemia [14]. …”

Section: Methodsmentioning

confidence: 99%

“…The severity of physiological disorders due to oxidative stress caused by excessive Zn decreased significantly on feeding these modified poultry egg (ME) mixed diets by restoring the minerals levels in blood serum and tissues as reported in the previous study [17]. Therefore, the present work was undertaken to study the effect of ME verses conventional egg (CE) on Zn induced hyperleptinemia [14] and results are reported in this paper.…”

Section: Introductionmentioning

confidence: 97%

“…In our previous study, we have reported that excessive Zn in diet induces obesity, hyperinsulinemia and hypercortisolemia as a consequence of ionic imbalance of Zn, Cu and Mg [12] resulting in oxidative stress [13] and leptin resistance in Wistar rats [14]. …”

Section: Introductionmentioning

confidence: 99%

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Attenuation of Zn-induced hyperleptinemia/leptin resistance in Wistar rat after feeding modified poultry egg

2012

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BackgroundThe prevalence of obesity is increasing exponentially world over. Leptin resistance/hyperleptinemia is attributed to its cause in majority of the obese humans where mutation in genetic component or ob gene has not been found operative. The generation of oxidative stress was suggested as its cause. In our previous study, we have reported that the inclusion of antioxidant enriched modified poultry egg (ME) in diet reversed the ionic imbalance and ameliorated the oxidative stress caused by excessive Zn in diet. In the present study, the efficacy of ME verses conventional egg (CE) was tested on Zn-induced leptin resistance in rat model to ascertain if the supplementation of antioxidants in the form of egg can reverse Zn-induced leptin resistance to leptin sensitive state.MethodsHyperleptinemia was induced in rats by feeding them Zn-supplemented hyperleptinemic diets-I and II (Zn-HL-Diet) for 2 months. Thereafter, half of them were fed either on CE or ME mixed Zn-HL-diets I and II for another two months. The data was analyzed applying one way Anova and Tukey’s HSD post hoc test.ResultsThe results revealed that food intake, gain in body weight, height and number/unit surface area of intestinal microvillus and serum leptin, glucose, insulin and cortisol were higher in CE and Zn-HL-Diet treated groups; serum Zn, Cu, Mg were higher and Cu and Mg in tissues were lower in them than the control group. In ME treated groups, these parameters were lower and were close to the control group. These changes resulted from the restoration of ionic balance of Zn, Cu and Mg in the blood serum and tissues including liver and hair in ME treated rats.ConclusionThe data suggest that Zn-induced leptin resistance can be attenuated through restoring the ionic balance of Zn, Cu and Mg through inclusion of antioxidants in diet such as these modified eggs. But further clinical studies are required before they are put to use for human consumption.

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Section: Discussionsupporting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Attenuation of Zn-induced hyperleptinemia/leptin resistance in Wistar rat after feeding modified poultry egg

2012

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“…Many researchers confirmed the positive effect of zinc on appetite and feed intake (Brody 1999;McDowell 2003;Taneja et al 2012). In this trial, due to the increasing amount of leptin and insulin around parturition, feed consumption was expected to reduce.…”

Section: Bcs and Feed Intakementioning

confidence: 56%

Investigation changes in production, some blood hormones, and metabolites, serum and colostrum IgG of calves of Holstein cows fed with two levels of zinc supplement in transitional period

Allahyari

Chaji

Mamuie

2019

Journal of Applied Animal Research

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Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken

Liu

Zhao

Zhang

et al. 2015

Biol Trace Elem Res

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This study aimed to investigate the effects of oral administration of trivalent chromium on the contents of Ca, Mg, Mn, Fe, Cu, and Zn in the heart, liver, and kidney. Different levels of 1/8, 1/4, and 1/2 LD50 (LD50 = 5000 mg/kg body mass) CrCl3 milligrams per kilogram body mass daily were added into the water to establish the chronic poisoning model. Ca, Mg, Mn, Fe, Cu, and Zn were detected with the flame atomic absorption spectrometry in the organs exposed 14, 28, and 42 days to CrCl3, respectively. Results showed that Cr was accumulated in the heart, liver, and kidney significantly (P < 0.05) with extended time and dose. The contents of Ca and Fe increased, whereas those of Mg, Mn, Cu, and Zn decreased in the heart, liver, and kidney of each treated group, which had a dose- and time-dependent relationship, but the contents of Mg and Zn in the heart took on a fluctuated change. These particular observations were different from those in the control group. In conclusion, the oral administration of CrCl3 could change the contents of Ca, Mg, Mn, Fe, Cu, and Zn in the heart, liver, and kidney, which may cause disorders in the absorption and metabolism of the metal elements of chickens.

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Excessive zinc in diet induces leptin resistance in Wistar rat through increased uptake of nutrients at intestinal level

Cited by 18 publications

References 32 publications

Attenuation of Zn-induced hyperleptinemia/leptin resistance in Wistar rat after feeding modified poultry egg

Attenuation of Zn-induced hyperleptinemia/leptin resistance in Wistar rat after feeding modified poultry egg

Investigation changes in production, some blood hormones, and metabolites, serum and colostrum IgG of calves of Holstein cows fed with two levels of zinc supplement in transitional period

Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken

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