“…According to proteomic studies, the endoplasmic reticulum of aging chondrocytes undergoes excessive sulfur oxidation, resulting in an inflammatory response. 22 Similar to the previous study, 6 the present data showed that both the mRNA and protein expression levels of β1,4-GalT-I in the OA mouse model were significantly higher than those in the control. To uncover the potential miRNAs targeting β1,4-GalT-I in OA, TargetScan was applied to predict a list of miRNAs based on β1,4-GalT-I as the target mRNA.…”