Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

Abstract

Osteoarthritis, as a common joint disease among middle-aged and elderly people, has many problems, such as diverse pathogenesis, poor prognosis and high recurrence rate, which seriously affects patients’ physical and mental health and reduces their quality of life. At present, the pathogenesis of osteoarthritis is not completely clear, and the treatment plan is mainly to relieve symptoms and ensure basic quality of life. Therefore, it is particularly urgent to explore the pathogenesis of osteoarthritis. Protein, as organic macromolecule which plays a major role in life activities, plays an important role in the development of disease. Through protein omics, this study found that with the increase of age, excessive sulfur oxidation occurred in endoplasmic reticulum of chondrocytes, which then drove the occurrence of inflammatory reaction, and provided a direction for the follow-up molecular targeted.

MicroRNA-15a/β1,4-GalT-I axis contributes to cartilage degeneration via NF-κB signaling in osteoarthritis

“…According to proteomic studies, the endoplasmic reticulum of aging chondrocytes undergoes excessive sulfur oxidation, resulting in an inflammatory response. 22 Similar to the previous study, 6 the present data showed that both the mRNA and protein expression levels of β1,4-GalT-I in the OA mouse model were significantly higher than those in the control. To uncover the potential miRNAs targeting β1,4-GalT-I in OA, TargetScan was applied to predict a list of miRNAs based on β1,4-GalT-I as the target mRNA.…”