Excessive Pesticide Use Likely to Cause the Onset of Myasthenia Gravis in the Moroccan Agricultural Population

Samih, Majda; Ahami, Ahmed Omar Touhami

doi:10.3923/pjbs.2020.917.921

Cited by 2 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, several studies have been conducted in agricultural populations. One of them revealed an increased prevalence of MG in adult men from rural areas in Morocco, including workers exposed to pesticides suspected of triggering autoimmune diseases, suggesting a role of these substances [ 66 ]. Another study detected an increased prevalence of MG among rural male adults in Israel, associating it with pesticide exposure [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

The epidemiology of myasthenia gravis

et al. 2021

View full text Add to dashboard Cite

Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. MG has become a prototype serving to understand both autoimmunity and the function of the NMJ better. The aim of this review is to synthesize some of the epidemiological data available. Epidemiological data regarding MG are important for postulating hypotheses regarding its etiology and facilitating the description of MG subtypes. Thus, adequate documentation through broad databases is essential. The incidence and prevalence of MG reported around the globe have been rising steadily and consistently over the past decades. Ethnic aspects, gender-related differences, and environmental risk factors have been described, implying that these might contribute to a specific phenotype, further suggesting that MG may be considered an umbrella term that covers several clinical entities.

show abstract

Section: Introductionmentioning

confidence: 99%