Excessive Muscle Activity Increases Over Time in Idiopathic REM Sleep Behavior Disorder

Iranzo, Álex; Ratti, Pietro Luca; Casanova‐Mollá, Jordi; Serradell, Mónica; Vilaseca, Isabel; Santamaría, Joan

doi:10.1093/sleep/32.9.1149

Cited by 102 publications

(67 citation statements)

References 15 publications

(5 reference statements)

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“…The results of this study also correspond with the fact that REM behavioral events (11), REM without atonia (RWA), increase over time in patients with iRBD (12), even in patients with still isolated RWA (13-15). Sasai-Sakuma et al discuss whether the more severe motor dysregulation of REM sleep in iRBD patients with pareidolia could indicate a more widespread neuropathological involvement (potentially cholinergic) in this subgroup.…”

supporting

confidence: 87%

What the “man in the moon” can tell us about the future of our brains

Högl

2017

Ann. Transl. Med.

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supporting

confidence: 87%

What the “man in the moon” can tell us about the future of our brains

Högl

2017

Ann. Transl. Med.

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“…RBD motor symptoms typically worsen with time (Iranzo et al, 2009b), suggesting that progressive neuronal degeneration contributes to RBD symptoms. While there is no clear evidence that dopaminergics influence RBD symptoms (Iranzo et al, 2009a), imaging studies nonetheless indicate that dysfunction of the nigrostriatal dopamine system is associated with RBD (Albin et al, 2000;Eisensehr et al, 2000).…”

Section: Increasing Inhibitory Tone Improves Rbd Symptomsmentioning

confidence: 99%

Impaired GABA and Glycine Transmission Triggers Cardinal Features of Rapid Eye Movement Sleep Behavior Disorder in Mice

Brooks¹,

Peever²

2011

J. Neurosci.

111

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Rapid eye movement (REM) sleep behavior disorder (RBD) is a neurological disease characterized by loss of normal REM motor inhibition and subsequent dream enactment. RBD is clinically relevant because it predicts neurodegenerative disease onset (e.g., Parkinson's disease) and is clinically problematic because it disrupts sleep and results in patient injuries and hospitalization. Even though the cause of RBD is unknown, multiple lines of evidence indicate that abnormal inhibitory transmission underlies the disorder. Here, we show that transgenic mice with deficient glycine and GABA transmission have a behavioral, motor, and sleep phenotype that recapitulates the cardinal features of RBD. Specifically, we show that mice with impaired glycine and GABA A receptor function exhibit REM motor behaviors, non-REM muscle twitches, sleep disruption, and EEG slowing-the defining disease features. Importantly, the RBD phenotype is rescued by drugs (e.g., clonazepam and melatonin) that are routinely used to treat human disease symptoms. Our findings are the first to identify a potential mechanism for RBD-we show that deficits in glycine-and GABA A -mediated inhibition trigger the full spectrum of RBD symptoms. We propose that these mice are a useful resource for investigating in vivo disease mechanisms and developing potential therapeutics for RBD.

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“…It is thought that excessive electromyographic (EMG) activity during REM sleep in RBD patients reflects dysfunction of the brainstem structures responsible for muscle atonia during REM sleep (2)(3)(4)(5). RBD is very common in several neurodegenerative diseases, including multiple system atrophy, dementia with Lewy bodies and Parkinson's disease (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Rapid Eye Movement Sleep Behavior Disorder in a Patient with Brainstem Lymphoma

et al. 2013

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Rapid eye movement (REM) sleep behavior disorder (RBD) is common in patients with neurodegenerative diseases. RBD occurring in a patient with brainstem lymphoma has not yet been reported. A 30-year-old man had an eleven-month history of violent motor and vocal behavior during sleep. Brain magnetic resonance imaging disclosed hypointensity T1 and hyperintensity T2 signals in the pontomesencephalic junction and at the upper/mid pons level. A stereotactic biopsy demonstrated the presence of diffuse large B-cell lymphoma. On polysomnography, there was enhanced submental and limb electromyographic tone and increased muscular activity during REM sleep. Chemotherapy diminished the dream-enacting behaviors. This case provides evidence that treatment aimed at the primary disease can partially improve the frequency of RBD.

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Excessive Muscle Activity Increases Over Time in Idiopathic REM Sleep Behavior Disorder

Abstract: Excessive tonic and phasic EMG activity during REM sleep increases over time in subjects with idiopathic RBD. This finding suggests that, in subjects with idiopathic RBD, there is an underlying progressive pathologic process damaging the brainstem structures that modulate REM sleep.

Cited by 102 publications

References 15 publications

What the “man in the moon” can tell us about the future of our brains

What the “man in the moon” can tell us about the future of our brains

Impaired GABA and Glycine Transmission Triggers Cardinal Features of Rapid Eye Movement Sleep Behavior Disorder in Mice

Rapid Eye Movement Sleep Behavior Disorder in a Patient with Brainstem Lymphoma

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