Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss
Yafang Lu,
Yuhan Shao,
Weiwei Cui
et al.
Abstract:The uterine epithelium undergoes a dramatic spatiotemporal transformation to enter a receptive state, involving a complex interaction between ovarian hormones and signals from stromal and epithelial cells. Redox homeostasis is critical for cellular physiological steady state; emerging evidence reveals that excessive lipid peroxides derail redox homeostasis, causing various diseases. However, the role of redox homeostasis in early pregnancy remains largely unknown. It is found that uterine deletion of Glutathio… Show more
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