Excessive Functional Coupling With Less Variability Between Salience and Default Mode Networks in Autism Spectrum Disorder

Chen, Ya-Yun; Uljarević, Mirko; Neal, Joshua; Greening, Steven G.; Yim, Hyungwook; Lee, Tae‐Ho

doi:10.1016/j.bpsc.2021.11.016

Cited by 11 publications

(14 citation statements)

References 73 publications

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“…Our analysis of intra-and inter-network FCs revealed differential changes in FCs in association with ASD traits. Our results are partially consistent with those of previous rs-and task-based fMRI studies (21,23,(71)(72)(73)(74)(75). In particular, we note the decreased FCs within the SN during the rest period.…”

Section: Relationship Between Asd Traits and The Triple Networksupporting

confidence: 92%

Differences in the functional connectivity of large-scale brain networks between young adults with subclinical attention-deficit/hyperactivity and autistic traits

Hirata

Yoshimura

Kobayashi

et al. 2022

Preprint

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Background Attentional impairments are associated with attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Previous evidence suggests both commonalities and differences in the nature of attention deficits between these disorders. This study aimed to investigate the neural correlates of ADHD and ASD traits in healthy individuals, focusing on the functional connectivity (FC) of the large-scale brain networks (LSBN) subserving attentional functions. Methods The participants were 61 healthy individuals (30 males; age, 21.9 ± 1.9 years). The Adult ADHD Self-Report Scale (ASRS) and Autism-Spectrum Quotient (AQ) were administered as indicators of ADHD and ASD traits, respectively. Performance in the continuous performance test (CPT) was used as a behavioural measure of sustained attentional function. Functional magnetic resonance imaging scans were performed during the resting state (Rest) and during the auditory oddball task (Odd). Regions of interest (ROI)-to-ROI analyses (FDR < 0.05) were performed to examine the relationship between FCs and psychological measures. The networks of interest were the default mode (DMN), frontal-parietal (FPN), and salience (SN) networks, as these are critical for cognitive processing (including attentional processing). Results ASRS scores, but not the AQ scores, were correlated with less frequent commission errors and shorter reaction times in the CPT. During Odd, ASRS and AQ scores were positively correlated with FC values within the DMN and FPN, respectively. The ASRS and AQ scores were positively and negatively correlated with FC values between the FPN and SN, respectively. During Rest, AQ scores were negatively and positively correlated with FC values within the SN and those between the DMN and SN, respectively. Limitations: Our sample size was relatively low, we used only the CPT to assess attentional function, and we did not examine continuity from subclinical to clinical individuals in their neural substrates. Conclusions A better performance in the CPT by individuals with subclinical ADHD traits suggests the positive effects of these traits on sustained attention. Differential associations between LSBN FCs and ASD/ADHD traits indicate different mechanisms of attentional processing in individuals with subclinical ADHD or ASD traits. This corroborates the notion of differences in sustained and selective attention between clinical ADHD and ASD.

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Section: Relationship Between Asd Traits and The Triple Networksupporting

confidence: 92%

Differences in the functional connectivity of large-scale brain networks between young adults with subclinical attention-deficit/hyperactivity and autistic traits

Hirata

Yoshimura

Kobayashi

et al. 2022

Preprint

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“…For instance, previous studies described specific alterations in resting‐state activity for the salience network during development in response to early trauma and in relation to ADHD (Rogers et al., 2021; Zhao et al., 2021). Moreover, DMN development during late childhood and adolescence has been previously described as influencing both physiological growth (Lei et al., 2022; Spencer‐Smith & Anderson, 2009) and abnormal psychopathology (Via et al., 2021), dynamically integrating with the salience network during typical development in order to modulate cognitive or social responsiveness (Chen et al., 2022; Valera‐Bermejo et al., 2021). A small effect for age was previously shown for the resting‐state activity of the DMN—in a sample of adults (Bluhm et al., 2008)—while the current study indicates medium age effects in the same region from 7 to 18 years of age.…”

Section: Discussionmentioning

confidence: 99%

Progressive Voxel‐Wise Homotopic Connectivity from childhood to adulthood: Age‐related functional asymmetry in resting‐state functional magnetic resonance imaging

Tarchi

Damiani

Vittori

et al. 2023

Developmental Psychobiology

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Homotopic connectivity during resting state has been proposed as a risk marker for neurologic and psychiatric conditions, but a precise characterization of its trajectory through development is currently lacking. Voxel-Mirrored Homotopic Connectivity (VMHC) was evaluated in a sample of 85 neurotypical individuals aged 7-18 years.VMHC associations with age, handedness, sex, and motion were explored at the voxel-wise level. VMHC correlates were also explored within 14 functional networks.Primary and secondary outcomes were repeated in a sample of 107 adults aged 21-50 years. In adults, VMHC was negatively correlated with age only in the posterior insula (false discovery rate p < .05, >30-voxel clusters), while a distributed effect among the medial axis was observed in minors. Four out of 14 considered networks showed significant negative correlations between VMHC and age in minors (basal ganglia r = -.280, p = .010; anterior salience r = -.245, p = .024; language r = -.222, p = .041; primary visual r = -.257, p = .017), but not adults. In minors, a positive effect of motion on VMHC was observed only in the putamen. Sex did not significantly influence age effects on VMHC. The current study showed a specific decrease in VMHC for minors as a function of age, but not adults, supporting the notion that interhemispheric interactions can shape late neurodevelopment.

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“…Signaling from limbic regions to the SAL has also been identified as key differentiator of both ADHD diagnosis and symptom presentation (Damiani et al, 2021). SAL dysfunction has also been associated with inattention in other disorders, such as multiple sclerosis and ASD (Chen et al, 2021; Loitfelder et al, 2012). Age related differences in LC-SAL connectivity have also been observed in older adult samples (Lee et al, 2020; Liebe et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Association of intrinsic functional connectivity between the locus coeruleus and salience network with attentional ability

Neal

Song

Katz

et al. 2022

Preprint

Self Cite

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The LC is a brainstem region associated with broad physiological and neural arousal as part of the release of norepinephrine, but it has increasingly been associated with multiple specific cognitive processes. These include sustained attention, deficits in which are associated with a variety of neuropsychological disorders. Neural models of attention deficits to date have focused on interrupted dynamics between the salience network (SAL) with the fronto-parietal network (FPN), which has been associated with task-switching and processing of external stimuli, respectively. Conflicting findings based on these regions suggest the possibility of upstream signaling leading to attention dysfunction, and recent research suggest the LC may play this role. In this study, resting-state functional connectivity (FC) and behavioral performance on an attention task was examined within 584 individuals. Analysis revealed significant clusters connected to the LC activity in the bilateral insula, anterior cingulate cortex (ACC), and bilateral ventral striatum, all regions associated with the SAL. Given previous findings that attention deficits may be caused by dysfunctions in network switching by the SAL, our findings here further suggest that dysfunction in LC signaling to the SAL may interfere with attention.

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Excessive Functional Coupling With Less Variability Between Salience and Default Mode Networks in Autism Spectrum Disorder

Cited by 11 publications

References 73 publications

Differences in the functional connectivity of large-scale brain networks between young adults with subclinical attention-deficit/hyperactivity and autistic traits

Differences in the functional connectivity of large-scale brain networks between young adults with subclinical attention-deficit/hyperactivity and autistic traits

Progressive Voxel‐Wise Homotopic Connectivity from childhood to adulthood: Age‐related functional asymmetry in resting‐state functional magnetic resonance imaging

Association of intrinsic functional connectivity between the locus coeruleus and salience network with attentional ability

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