Excessive daytime sleepiness and its impact on quality of life in de novo Parkinson’s disease

Yoo, Sang‐Won; Kim, Joong‐Seok; Oh, Yoon‐Sang; Ryu, Dong-Woo; Lee, Kwang Soo

doi:10.1007/s10072-019-03785-8

Cited by 32 publications

(22 citation statements)

References 33 publications

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“…Our study indicated that EDS, evaluated by the ESS, was different among the three groups. In addition, consistent with previous studies that investigated the impacts of EDS on QoL (Kuhlman et al, 2019;Xiang et al, 2019;Yoo et al, 2019), we found that EDS was an important contributor to QoL in all PD patients. It was reported that EDS was independently correlated to cognitive impairment in PD (Marinus et al, 2018).…”

Section: Discussionsupporting

confidence: 92%

Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Fan

Liang

et al. 2020

Front. Aging Neurosci.

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Background: Quality of life (QoL) was worse in Parkinson's disease patients with mild cognitive impairment (PD-MCI) or dementia (PDD) than PD patients with normal cognition (PD-NC). The aim of this study was to investigate and compare the potential heterogeneous determinants of QoL in PD patients with different cognitive statuses. Methods: We recruited 600 PD patients, including 185 PD-NC patients, 336 PD-MCI patients and 79 PDD patients, in this cross-sectional study. All patients completed the QoL assessment by the 39-item Parkinson's Disease Questionnaire (PDQ-39), as well as clinical evaluations and neuropsychological tests. The determinants of the QoL were analyzed by multiple stepwise regression analysis. Results: QoL was more impaired across the three groups (PD-NC < PD-MCI < PDD). The Unified Parkinson's Disease Rating Scale part III (UPDRS-III) score, Geriatric Depression Rating Scale (GDS) score and daily levodopa equivalent dose (LED) were independent variables of PDQ-39 in PD-NC patients. The GDS score, disease duration, UPDRS-III score, Epworth Sleepiness Score (ESS) and sex were independent variables of PDQ-39 in PD-MCI patients. The GDS score and disease duration were independent variables of PDQ-39 in PDD patients. Conclusion: The determinants of QoL in PD-NC, PD-MCI and PDD patients were heterogeneous. Motor function was considered to be the most crucial determinant for QoL in PD-NC, while depression was indicated to be the most vital determinant for PD-MCI and PDD. For QoL improvement, clinicians might need to focus more on motor function in PD-NC patients and on depression in PD-MCI and PDD patients.

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Section: Discussionsupporting

confidence: 92%

Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Fan

Liang

et al. 2020

Front. Aging Neurosci.

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“…Excessive daytime sleepiness (EDS), which refers to the inability to stay awake and alert during the day with sleep occurring at inappropriate times (Zhu et al, 2016) is a ubiquitous non-motor symptom in Parkinson's disease (PD). Convergent evidence has suggested that EDS is associated with falls, other non-motor symptoms (e.g., depression), and poorer quality of life in PD (Spindler et al, 2013;Chen et al, 2014;Yoo et al, 2019). Understanding the pathogenesis of EDS in PD is important to guide future treatment development.…”

Section: Introductionmentioning

confidence: 99%

Increased Activation of Default Mode Network in Early Parkinson’s With Excessive Daytime Sleepiness

Ooi

Wen

et al. 2019

Front. Neurosci.

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Background and Objectives: The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.Methods: Early PD patients comprising eighty-one patients without EDS (EDS−) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS− groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression.Results: EDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positive correlation was found between connectivity of the ventromedial prefrontal cortex in the pDMN and ESS.Conclusion: EDS+ patients are likely to display increased activation in the DMN, suggesting neural compensation in early PD or impaired attentiveness due to mechanisms such as mind-wandering.

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“… 53 It is well recognized that EDS, measured by ESS, negatively impacts QoL in PD. 47 , 54 In this study, we found that ESS was an independent determinant of QoL in both PD‐MMP and PD‐IM patients, while it had no significant impact on QoL in PD‐DM patients. Except for male sex, the use of dopamine agonists is the greatest independent risk factor for EDS 37 , and it seems to increase EDS in a dose‐dependent manner.…”

Section: Discussionmentioning

confidence: 57%

Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes

Fan

Zhang

Liang

et al. 2021

Ann Clin Transl Neurol

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Objective New subtyping classification systems of Parkinson’s disease (PD) have been proposed for phenotyping patients into three different subtypes: mild motor‐predominant (PD‐MMP), intermediate (PD‐IM) and diffuse malignant (PD‐DM). The quality of life (QoL) underlying the novel PD clinical subtypes is unknown. This study aimed explore the feasibility of the classification in Chinese PD patients and to investigate the potential heterogeneous determinants of QoL among the three subtypes. Methods 298 PD patients were enrolled, including 129 PD‐MMP patients, 121 PD‐IM patients and 48 PD‐DM patients. All patients completed the QoL assessment, clinical evaluations and neuropsychological tests. Univariate linear analysis and multiple stepwise regression analysis were performed to identify determinants of QoL. Results Compared to PD‐MMP patients, PD‐IM and PD‐DM patients had more impaired QoL. The Geriatric Depression Rating Scale (GDS) score, Non‐Motor Symptoms Questionnaire (NMSQ) score, Unified Parkinson’s Disease Rating Scale part III (UPDRS‐III) score and Epworth Sleepiness Score (ESS) were independent contributors to QoL in PD‐MMP patients. The GDS score, ESS and sniffin’ sticks screening 12 test score were independent contributors to QoL in PD‐IM patients. The GDS score and Mini Mental State Examination score were independent contributors to QoL in PD‐DM patients. Interpretation The new novel subtyping classification is feasible for Chinese PD patients. Although depression was the most crucial determinant for QoL in PD‐MMP, PD‐IM and PD‐DM patients, the other contributors of QoL in the three subtypes were heterogeneous. These findings may prompt clinicians to target specific factors for improving QoL depending on PD subtypes.

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Excessive daytime sleepiness and its impact on quality of life in de novo Parkinson’s disease

Cited by 32 publications

References 33 publications

Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Increased Activation of Default Mode Network in Early Parkinson’s With Excessive Daytime Sleepiness

Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes

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