Excessive daytime sleepiness after traumatic brain injury

Crichton, Thomas; Singh, Rajiv; Abosi-Appeadu, Kessewa; Dennis, Gary

doi:10.1080/02699052.2020.1810316

Cited by 13 publications

(12 citation statements)

References 41 publications

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“…This study demonstrates that only 26.1% of students get more than 7 hours of night sleep that a normal young individual should have [ 31 ]. On the other hand, 42% of the students indicated that they have less than 6 hours of night sleep.…”

Section: Discussionmentioning

confidence: 99%

Daytime Sleepiness among Medical Colleges’ Students in Jordan: Impact on Academic Performance

et al. 2022

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Introduction. Sleep disorders are extremely prevalent in the general population. College students are more susceptible to sleep problems. This is due to the increased competition in getting a job position and the current alterations in the labor market. Poor sleep is prevalent and has deleterious effects on college students, but its frequency among college students has not been documented in Jordan. So, the aims of this study are to assess the prevalence of daytime sleepiness among medical college students in Jordan and to look for any links between daytime sleepiness and academic performance. Methods. A cross-sectional study performed on medical and paramedical specialties students and Epworth sleepiness Sscale (ESS) was used. To assess the students’ academic performance, the cumulative grade point average was utilized. Results. 977 students from five medical colleges participated in the study. ESS scores were abnormal in 34.4% of students and were considered to have daytime sleepiness. Significant lower ESS scores were associated with students who reported good sleep quality than students who reported poor sleep quality. Significant lower ESS scores were reported by students who slept more than 7 hours compared with students who slept less than 6 hours. The ESS scores were not significantly associated with students’ CPGA. Conclusion. Daytime sleepiness is highly prevalent among medical students in Jordan. The data of this study might be very helpful to assess the academic policy makers to develop intervention strategies that resolve the sleep disturbances in college students and reduce its impact on the academic achievements.

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Section: Discussionmentioning

confidence: 99%

Daytime Sleepiness among Medical Colleges’ Students in Jordan: Impact on Academic Performance

et al. 2022

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“…More severe injuries have resulted in increased incidence of daytime sleepiness which has been associated with symptom severity and anxiety measures ( Crichton et al, 2020 ). A sample of TBI patients showed significantly longer sleep times and daytime sleepiness than healthy controls, which persisted at least 18 months following injury ( Imbach et al, 2016 ).…”

Section: Circadian Desynchrony and Tbi Symptomologymentioning

confidence: 99%

The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury

Yamakawa

Brady

Sun

et al. 2020

Neurobiology of Sleep and Circadian Rhythms

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Traumatic brain injury (TBI) is a complex and costly worldwide phenomenon that can lead to many negative health outcomes including disrupted circadian function. There is a bidirectional relationship between the immune system and the circadian system, with mammalian coordination of physiological activities being controlled by the primary circadian pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN receives light information from the external environment and in turn synchronizes rhythms throughout the brain and body. The SCN is capable of endogenous self-sustained oscillatory activity through an intricate clock gene negative feedback loop. Following TBI, the response of the immune system can become prolonged and pathophysiological. This detrimental response not only occurs in the brain, but also within the periphery, where a leaky blood brain barrier can permit further infiltration of immune and inflammatory factors. The prolonged and pathological immune response that follows TBI can have deleterious effects on clock gene cycling and circadian function not only in the SCN, but also in other rhythmic areas throughout the body. This could bring about a state of circadian desynchrony where different rhythmic structures are no longer working together to promote optimal physiological function. There are many parallels between the negative symptomology associated with circadian desynchrony and TBI. This review discusses the significant contributions of an immune-disrupted circadian system on the negative symptomology following TBI. The implications of TBI symptomology as a disorder of circadian desynchrony are discussed.

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“…3 The prevalence of sleep disturbances is reported in 30-70%, 3 41.7% have sleepiness or fatigue (41.7%), 36% apnea, 30% poor quality of sleep and insomnia. 4 The causes of sleep disorders in patients with acquired brain damage include a complex interrelation between pathophysiological (structural, electrical or neurochemical) processes, variables associated with the injury (severity, site and extent of injury, loss of consciousness, time of evolution), previous sleep habits and alterations, psychological factors (mood changes, neuropsychiatric sequelae), environmental factors (noise, light, invasive treatments, adverse effect of medications), another type of injury sequelae (pain, immobility), social factors (type of care, family role), among others. [2][3][4][5] In addition to altering daytime energy levels, sleep disorders can exacerbate other conditions such as cognitive deficits (predominantly in attention and memory), pain, fatigue, mood disturbances, and contribute to poor rehabilitation achievements, which can have an impact on functional recovery and lead to low quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…4 The causes of sleep disorders in patients with acquired brain damage include a complex interrelation between pathophysiological (structural, electrical or neurochemical) processes, variables associated with the injury (severity, site and extent of injury, loss of consciousness, time of evolution), previous sleep habits and alterations, psychological factors (mood changes, neuropsychiatric sequelae), environmental factors (noise, light, invasive treatments, adverse effect of medications), another type of injury sequelae (pain, immobility), social factors (type of care, family role), among others. [2][3][4][5] In addition to altering daytime energy levels, sleep disorders can exacerbate other conditions such as cognitive deficits (predominantly in attention and memory), pain, fatigue, mood disturbances, and contribute to poor rehabilitation achievements, which can have an impact on functional recovery and lead to low quality of life. 2,5,6 F o r t h e d i a g n o s i s o f s l e e p d i s o r d e r s , polysomnography (PSG) has been considered the gold standard, providing objective and quantitative information of physiological indicators in a transversal manner, however, its complexity, low availability and high costs make it difficult for it to be widely available in all patients.…”

Section: Introductionmentioning

confidence: 99%

“…These being easily administered and low-cost, the scales are largely used as a resource to improve the initial characterization of patients and identify the parameters to be evaluated in a PSG. 7,8 Although there are numerous studies that have described the sequelae in sleep after acquired brain damage, [1][2][3][4]9 little is known about the chronicity of this type of manifestations and the differential characteristics between post-stroke and post-TBI patients, which may be interesting considering the high prevalence of this type of lesion and its impact on functionality.…”

Section: Introductionmentioning

confidence: 99%

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Desórdenes de sueño en pacientes con daño cerebral adquirido, factores asociados y su impacto sobre la funcionalidad

Carrillo‐Mora¹,

Sidonio-Aguayo²,

Márquez-Vázquez³

et al. 2022

Investigación en Discapacidad

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Objective: To identify the prevalence of sleep disorders in chronic post-stroke and post-traumatic brain injury (TBI) patients, to determine the risk factors and their impact on functionality in activities of daily life. Material and methods: Cross-sectional clinical study that included adults ≥ 18 years with a history of acquired brain damage (post-stroke or post-TBI). Sociodemographic data and clinical history were obtained, and the following instruments were applied: Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale, the Berlin Questionnaire © Sleep Apnea, the Barthel's functionality index, the Hamilton Depression Rating Scale and the Beck Anxiety Inventory. Results: We included 116 patients, 91 post-stroke (78.4%) and 25 post-TBI (21.6%), mean age was 56.58 years (SD = 19.37). In post-stroke patients, the following risk factors were identified: diabetes (OR = 3.01; 95% CI = 1.13-8.01 for poor sleep quality), multiple comorbidities (OR = 3.78; 95% CI = 1.04-13.67 for quality of sleep), depression (OR = 2.46; 95% CI = 2.46-25.80 for apnea; OR = 7.94; 95% CI = 1.25-10.82 for insomnia) and anxiety (OR = 17.84; 95% CI = 2.28-139.64 for insomnia). In post-TBI patients, the following were identified as risk factors: overweight/obesity (OR = 11.25; 95% CI = 1.64-76.84 for poor sleep quality) and coma (OR = 2.33; 95% CI = 1.42-3.82 for sleepiness). The risk factor for functional loss in post-stroke is apnea (OR = 2.63; 95% CI = 1.05-6.54) and in post-TBI the poor quality of sleep (OR = 8.25; 95% CI = 1.15-50.03). Conclusion: Post-stroke and post-TBI patients have a high prevalence of sleep disorders and its comorbidities increase the risk of chronic sleep disorders and functional loss. ResumenObjetivo: Identificar la prevalencia de trastornos en el sueño en pacientes post-stroke y post-TCE, determinar los factores de riesgo y su impacto en la funcionalidad en actividades de la vida diaria. Material y métodos: Estudio clínico transversal que incluyó adultos ≥ de 18 años con antecedente de daño cerebral adquirido (post-stroke o postraumatismo craneoencefálico). Se obtuvieron datos sociodemográficos y antecedentes clínicos, y se aplicaron los siguientes instrumentos: PittsburghSleep Quality Index, the Epworth Sleepiness Scale, the Berlin questionnaire sleep apnea, the Barthel's

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Excessive daytime sleepiness after traumatic brain injury

Cited by 13 publications

References 41 publications

Daytime Sleepiness among Medical Colleges’ Students in Jordan: Impact on Academic Performance

Daytime Sleepiness among Medical Colleges’ Students in Jordan: Impact on Academic Performance

The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury

Desórdenes de sueño en pacientes con daño cerebral adquirido, factores asociados y su impacto sobre la funcionalidad

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