Excessive contralateral motor overflow in schizophrenia measured by fMRI

Minzenberg, Michael; Yoon, Jangho; Soosman, Steffan K.; Carter, Cameron S.

doi:10.1016/j.pscychresns.2012.03.005

Cited by 3 publications

(2 citation statements)

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“…Kodama and colleagues trained patients and controls on a simple finger sequence learning task, demonstrating that compared to healthy controls, patients hyper-activated pre-motor cortex following sequence learning [82]. This pattern of hyper-activation is suggestive of impaired efficiency of motor control and learning mechanisms, and was conceptually replicated in a separate study by Minzenberg and colleagues [83]. When patients were required to perform a basic sensorimotor detection task, they hyper-activated ipsi-lateral (to the response hand) M1 compared to healthy controls.…”

Section: Dysfunction In Regions Of the Core And Extended Motor Networmentioning

confidence: 92%

“…Neuroleptic naïve deficit syndrome patients (relative to non-deficit syndrome patients) are characterized by increases in spontaneous movement disorders, consistent with the role of the basal ganglia in mediating both schizophrenia symptomatology and movement function (108). Thus, impaired activity in the basal ganglia with hyperactivity in the primary, premotor, and somatosensory cortices, is thought to lead to cortical motor overflow and subsequent motor disturbances (83). …”

Section: Dysfunction In Regions Of the Core And Extended Motor Netmentioning

confidence: 99%

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Motor system dysfunction in the schizophrenia diathesis: Neural systems to neurotransmitters

Abboud

Noronha

Diwadkar³

2017

Eur. psychiatr.

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Motor control is a ubiquitous aspect of human function, and from its earliest origins, abnormal motor control has been proposed as being central to schizophrenia. The neurobiological architecture of the motor system is well understood in primates and involves cortical and sub-cortical components including the primary motor cortex, supplementary motor area, dorsal anterior cingulate cortex, the prefrontal cortex, the basal ganglia, and cerebellum. Notably all of these regions are associated in some manner to the pathophysiology of schizophrenia. At the molecular scale, both dopamine and γ-Aminobutyric acid (GABA) abnormalities have been associated with working memory dysfunction, but particularly relating to the basal ganglia and the prefrontal cortex respectively. As evidence from multiple scales (behavioral, regional and molecular) converges, here we provide a synthesis of the bio-behavioral relevance of motor dysfunction in schizophrenia, and its consistency across scales. We believe that the selective compendium we provide can supplement calls arguing for renewed interest in studying the motor system in schizophrenia. We believe that in addition to being a highly relevant target for the study of schizophrenia related pathways in the brain, such focus provides tractable behavioral probes for in vivo imaging studies in the illness. Our assessment is that the motor system is a highly valuable research domain for the study of schizophrenia.

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Section: Dysfunction In Regions Of the Core And Extended Motor Networmentioning

confidence: 92%

Section: Dysfunction In Regions Of the Core And Extended Motor Netmentioning

confidence: 99%

Motor system dysfunction in the schizophrenia diathesis: Neural systems to neurotransmitters

Abboud

Noronha

Diwadkar³

2017

Eur. psychiatr.

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Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia

et al. 2013

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This study sought to characterise force variability and motor overflow in 12 individuals with Friedreich ataxia (FRDA) and 12 age- and gender-matched controls. Participants performed a finger-pressing task by exerting 30 and 70 % of their maximum finger force using the index finger of the right and left hand. Control of force production was measured as force variability, while any involuntary movements occurring on the finger of the other, passive hand, was measured as motor overflow. Significantly greater force variability in individuals with FRDA compared with controls is indicative of cortico-cerebellar disruption affecting motor control. Meanwhile, significantly greater motor overflow in this group provides the first evidence of possible abnormal inter-hemispheric activity that may be attributable to asymmetrical neuronal loss in the dentate nucleus. Overall, this study demonstrated a differential engagement in the underlying default processes of the motor system in FRDA.

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