Excessive alcohol consumption favours high risk polyp or colorectal cancer occurrence among patients with adenomas: a case control study

Abstract

Background and aims: Excessive alcohol consumption is a risk factor for developing colorectal adenomas. This study aimed to investigate the influence of excessive alcohol consumption on the occurrence of high risk polyps (adenoma >10 mm, villous component, high grade dysplasia) or colorectal cancer among patients with at least one colonic adenoma. Patients and methods: Three groups of patients with at least one colorectal adenoma were included in a case control study: 401 heavy drinkers (group HD, mean daily alcohol intake 117 (SD 4) g/day for a mean duration of 22 (SD 0.6) years), aged 57 (0.5) years (78% men); 152 patients suffering from irritable bowel syndrome (IBS), aged 61 (0.9) years (57% male); and 108 patients with a family history (FH) of colorectal adenoma or cancer, aged 55 (1) years (64% male). Exclusion criteria were: anaemia, haematochezia, personal history of colorectal adenoma or cancer, and for groups HD and IBS a family history of colorectal adenoma and/or cancer. Relative risks were estimated by the odds ratio (OR) using a logistic regression model and were expressed with 95% confidence interval (CI). Results: After age and sex adjustment, the likelihood of having an adenoma >10 mm was higher in group HD than in the IBS group (OR 1.8, 95% CI (1.2-2.7)) and the likelihood of having high risk adenomas or cancer was higher in group HD compared with the IBS group (OR 1.6, 95% CI (1.2-2.1)) and the FH group although this was not significant (OR 1.6, 95% CI (0.97-2.6) (p=0.081); 90% CI (1.03-2.4)). After age and sex adjustment, the likelihood of having an adenoma with high grade dysplasia or cancer was higher in group HD than in the IBS group (OR 1.7, 95% CI (1.02-2.8)) or group FH, although this was not significant (OR 3.7, 95% CI (0.98-15) (p=0.076); 90% CI (1.10-12.47)). Conclusion:In patients with at least one colorectal adenoma, excessive alcohol consumption increases the likelihood of developing high risk adenomas or colorectal cancer.

The Effect of Flavonoids in Soybean Products in Lymphocytes from IBD and Colon Cancer Patients After Treatment with Food Mutagens and Hydrogen Peroxide

“…Despite this fact we were able to detect an age effect in a >50 age group. Although smoking and alcohol consumption is associated with an increased risk for colorectal cancer (Bardou et al, 2002;Emmons et al, 2005) probably due to DNA damage via increased levels of oxidative stress (Lodovici and Bigagli, 2009;Obe and Anderson, 1987;Pool-Zobel et al, 2004), no statistically significant differences were found in our study when focussing on smoking habits, alcohol intake or diet. This was also the case in the IBD study (Study I).…”

Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites

“…The majority of individual casecontrol [10][11][12]39,[41][42][43][44][45] and cohort studies [14][15][16]18,25,40,[46][47][48][49] have shown rather inconsistent results, which in part can be explained by differing (methodological) aspects of these studies and lack of statistical power. To the best of our knowledge, our study is currently the largest single prospective study that has investigated associations between alcohol consumption and CRC.…”

Avoiding Pitfalls: What an Endoscopist Should Know in Liver Transplantation—Part 1

“…The incidence of both colonic polyps and adenomas is said to be higher in the cirrhotics than in the general population due to an uncertain reason [183,184]. The prevalence of colonic polyps in cirrhotics varies from 8 to 46%.…”