Excess risk of venous thromboembolism in hip fracture patients and the prognostic impact of comorbidity

Pedersen, Alma B; Ehrenstein, Véra; Szépligeti, Szimonetta Komjáthiné; Sørensen, Henrik Toft

doi:10.1007/s00198-017-4213-y

Cited by 27 publications

(19 citation statements)

References 41 publications

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“…The absolute risk of VTE after orthopedic surgery varies depending on the population studied. In a Northern European population expected to be high risk for VTE, the cumulative incidence of VTE was 0.73% within 30 days and 0.83% within 31-365 days after hip fracture surgery [105]. Prior to hospital discharge, VTE occurs in 1.09% of total hip arthroplasty patients and 0.53% of total knee arthroplasty patients [106].…”

Section: Surgerymentioning

confidence: 99%

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Prevention of Venous Thromboembolism in 2020 and Beyond

Nicholson

Chan

Bhagirath

et al. 2020

JCM

120

109

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Venous thromboembolism (VTE) is the third most common cause of vascular mortality worldwide and comprises deep-vein thrombosis (DVT) and pulmonary embolism (PE). In this review, we discuss how an understanding of VTE epidemiology and the results of thromboprophylaxis trials have shaped the current approach to VTE prevention. We will discuss modern thromboprophylaxis as it pertains to genetic risk factors, exogenous hormonal therapies, pregnancy, surgery, medical hospitalization, cancer, and what is known thus far about VTE in COVID-19 infection.

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Section: Surgerymentioning

confidence: 99%

“…In Korean patients, the risk of PE after total hip and knee replacement approximates 0.44% [107]. When VTE is diagnosed after total hip arthroplasty, mortality is estimated at 30% across a variety of populations, with an absolute risk of fatal PE of approximately 0.2% [105][106][107].…”

Section: Surgerymentioning

confidence: 99%

Prevention of Venous Thromboembolism in 2020 and Beyond

Nicholson

Chan

Bhagirath

et al. 2020

JCM

120

109

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“…Besides, hip fracture patients were at increased excess risk of venous thromboembolism, myocardial infarction and stroke up to one year following fracture. 45,46…”

Section: Examples Of Researchmentioning

confidence: 99%

<p>The Danish Multidisciplinary Hip Fracture Registry 13-Year Results from a Population-Based Cohort of Hip Fracture Patients</p>

Kristensen¹,

Röck²,

Christensen³

et al. 2020

CLEP

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Aim of the Registry: The aim of the Danish Multidisciplinary Hip Fracture Registry (DMHFR) is to collect data on processes of treatment, nursing care and rehabilitation as well as outcomes for patients with hip fracture in Denmark, and thereby monitor and improve the quality. Study Population: Hip fracture patients at age 65 or older that have undergone surgery with arthroplasty or internal fixation since 2004. Main Variables: DMHFR collects quality indicators and descriptive variables. Quality indicators include eight process performance measures within treatment, nursing care and rehabilitation, reflecting recommendations from the national clinical guideline for hip fracture patients, and three outcome measures including survival within 30-days, unplanned acute readmission within 30 days and reoperation within 2 years. Descriptive variables include a number of patient-and surgery-related characteristics. All data are collected prospectively. Results: By the end of 2018, the DMHFR included 86,438 hip fracture patients. Since 2006, all hospital departments in Denmark, treating patients with hip fracture, have reported improvement in quality of care and improvement in survival, and reoperation over time as well as high completeness of variables registration. Conclusion: The DMHFR is a well-established nationwide clinical registry, which plays a key role for monitoring and improving hip fracture care in Denmark. The registry can further be linked to a range of other nationwide registries in order to answer a number of relevant clinical research questions.

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“…5-62% when there was a delay for more than 48h [5]. Pedersen et al [6] have proposed that hip fracture was associated with increased subsequent risk of VTE in a population-based cohort study of 110563 patients with incident hip fracture. The risk of VTE increased 17-fold in the first 30 days after hip fracture, declining to a 2.1 fold increase from 31 to 365 days following hip fracture.…”

Section: Introductionmentioning

confidence: 99%

Preoperative anemia and total hospitalization time are the independent factors of preoperative deep venous thromboembolism in Chinese elderly undergoing hip surgery

Feng

Yuan

et al. 2020

Preprint

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Background This study was designed to explore the prevalence and risk factors of preoperative deep venous thromboembolism (DVT) in Chinese elderly with hip fracture. Methods From January 1, 2012, to December 31, 2018, 273 elderly patients over 70 years old with elective hip surgery were collected from the electronic medical records. Collected data included demographic characteristics, comorbidities, ASA classification, types of previous operations, types of anesthesia, operation time, fracture to operation time, preoperative hemoglobin level, anemia, blood-gas analysis, whether transfusion, preoperative hospitalization, postoperative hospitalization, cardiac function, electrocardiograph, lower limb venous ultrasonography and hospitalization time. Results In these 273 patients, 15(5.6%) had ultrasonography evidence of DVT in affected limbs before surgery. Three of all patients received an temporary inferior vena cave filter placement preoperatively. Fracture to surgery time, preoperative hemoglobin level, anemia, preoperative hospitalization, pulmonary disease and total hospitalization time were statistically different between DVT group and non-DVT group (P<0.05 for all). Moreover, preoperative anemia (OR: 0.144, 95%CI: 0.026-0.799, P=0.027) and total hospitalization time (OR: 1.135; 95%CI: 1.023-1.259, P=0.017) were the two independent risk factors for preoperative DVT. Conclusion Preoperative anemia and total hospitalization time were independent risk factors for venous DVT in Chinese elderly with hip fracture.

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Excess risk of venous thromboembolism in hip fracture patients and the prognostic impact of comorbidity

Abstract: Hip fracture patients were at increased excess risk of VTE up to 1 year following their fracture. During the first year, interaction between hip fracture and comorbidity was observed among patients with severe and very severe comorbidity.

Cited by 27 publications

References 41 publications

Prevention of Venous Thromboembolism in 2020 and Beyond

Prevention of Venous Thromboembolism in 2020 and Beyond

<p>The Danish Multidisciplinary Hip Fracture Registry 13-Year Results from a Population-Based Cohort of Hip Fracture Patients</p>

Preoperative anemia and total hospitalization time are the independent factors of preoperative deep venous thromboembolism in Chinese elderly undergoing hip surgery

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