Excess mortality after hip fracture in elderly persons from Europe and the <scp>USA</scp>: the <scp>CHANCES</scp> project

Katsoulis, Michail; Benetou, Vassiliki; Karapetyan, Tina; Feskanich, Diane; Grodstein, Francine; Pettersson-Kymmer, Ulrika; Eriksson, Sture; Wilsgaard, Tom; Jørgensen, Lone; Ahmed, Luai A.; Schöttker, Ben; Brenner, Hermann; Bellavia, Andrea; Wolk, Alicja; Kubínová, Růžena; Stegeman, Bernardine H.; Bobák, Martin; Boffetta, Paolo; Trichopoulou, Antonia

doi:10.1111/joim.12586

Cited by 265 publications

(182 citation statements)

References 38 publications

(61 reference statements)

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“…The physiologic stress of hip fracture may render these individuals more susceptible to complications of and demise from common comorbid conditions compared with individuals with more robust physiologic reserves. Three studies, including a recent meta‐analysis across eight cohorts, have reported the association of hip fracture with early incident mortality to be indeed stronger among those with a higher burden of pre‐fracture comorbid illness . The findings of Andrich and colleagues are also consistent with the hypothesis that pre‐fracture reduced functional status may also be an effect modifier of the association between major osteoporotic fractures and mortality.…”

Section: Early Post‐fracture Mortality: the Case Of Pelvis Fracturesmentioning

confidence: 76%

Mortality After Osteoporotic Fractures: What Proportion Is Caused by Fracture and Is Preventable?

Schousboe

2017

Journal of Bone and Mineral Research

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Section: Early Post‐fracture Mortality: the Case Of Pelvis Fracturesmentioning

confidence: 76%

Mortality After Osteoporotic Fractures: What Proportion Is Caused by Fracture and Is Preventable?

Schousboe

2017

Journal of Bone and Mineral Research

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“…Roughly 1 in 2 white women and 1 in 5 men are predicted to have an osteoporosis‐related fracture in their lifetime in the US . As the population ages, the risk of fractures in the advanced age group, which is associated with high morbidity and mortality rate, should increase . Therefore, it is important to establish noninvasive therapy to promote healing of compromised fracture repair in long bones and vertebrae.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intermittent Administration of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on Fracture Healing: A Narrative Review of Animal and Human Studies

Yamashita

McCauley

2019

JBMR Plus

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Intermittent administration of parathyroid hormone (PTH) stimulates skeletal remodeling and is a potent anabolic agent in bone. PTH‐related protein (PTHrP) is anabolic acting on the same PTH1 receptor and is in therapeutic use for osteoporosis. The body of literature for PTH actions in fracture healing is emerging with promising yet not entirely consistent results. The objective of this review was to perform a literature analysis to extract up‐to‐date knowledge on the effects of intermittent PTH and PTHrP therapy in bone fracture healing. A literature search of the PubMed database was performed. Clinical case studies and articles related to “regeneration,” “implant,” and “distraction osteogenesis” were excluded. A narrative review was performed to deliberate the therapeutic potential of intermittent PTH administration on fracture healing. A smaller number of studies centered on the use of PTHrP or a PTHrP analog were also reviewed. Animal studies clearly show that intermittent PTH therapy promotes fracture healing and revealed the strong therapeutic potential of PTH. Human subject studies were fewer and not as consistent as the animal studies yet provide insight into the potential of intermittent PTH administration on fracture healing. Differences in outcomes for animal and human studies appear to be attributed partly to variable doses, fracture sites, age, remodeling patterns, and bone architectures, although other factors are involved. Future studies to examine the dose, timing, and duration of PTH administration will be necessary to further delineate the therapeutic potential of PTH for fracture healing in humans. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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“…In a study of women in the USA, the incidence of any clinical fracture at 1 and 2 years following the initial fracture was 10% and 18%, respectively [26], but the corresponding figures for women ≥ 75 years of age were higher, with a 2-year fracture risk of 25%. All-cause mortality is also highest in the year following a hip fracture [5, 10, 23, 27, 28]. …”

Section: Introductionmentioning

confidence: 99%

Risk of imminent fracture following a previous fracture in a Swedish database study

et al. 2019

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SummaryThis study examined the imminent risk of a future fracture within 1 and 2 years following a first fracture in women aged 50 years and older and assessed independent factors associated with risk of subsequent fractures. The study highlights the need to intervene rapidly after a fracture to prevent further fractures.IntroductionThis study aims to determine the imminent risk of subsequent fractures within 1 and 2 years following a first fracture and to assess independent factors associated with subsequent fractures.MethodsRetrospective, observational cohort study of women aged ≥ 50 years with a fragility fracture was identified from Swedish national registers. Clinical/demographic characteristics at the time of index fracture and cumulative fracture incidences up to 12 and 24 months following index fracture were calculated. Risk factors for subsequent fracture were identified using multivariate regression analysis.ResultsTwo hundred forty-two thousand one hundred eight women (mean [SD] age 74 [12.5] years) were included. The cumulative subsequent fracture incidence at 12 months was 7.1% (95% confidence interval [CI], 6.9–7.2) and at 24 months was 12.0% (95% CI, 11.8–12.1). The rate of subsequent fractures was highest in the first month (~ 15 fractures per 1000 patient-years) and remained steady between 4 and 24 months (~ 5 fractures/1000 patient-years). Higher age was an independent risk factor for imminent subsequent fractures (at 24 months, sub-distribution hazard ratio [HR], 3.07; p < 0.001 for women 80–89 years [reference 50–59 years]). Index vertebral fracture was a strong independent risk factor for subsequent fracture (sub-distribution HR, 2.72 versus hip fracture; p < 0.001 over 12 months; HR, 2.23; p < 0.001 over 24 months).ConclusionsOur findings highlight the need to intervene rapidly after any fragility fracture in postmenopausal women. The occurrence of a fragility fracture provides healthcare systems with a unique opportunity to intervene to reduce the increased risk of subsequent fractures.Electronic supplementary materialThe online version of this article (10.1007/s00198-019-04852-8) contains supplementary material, which is available to authorized users.

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Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project

Abstract: In this large population-based sample of older persons across eight cohorts, hip fracture was associated with excess short- and long-term all-cause mortality in both sexes.

Cited by 265 publications

References 38 publications

Mortality After Osteoporotic Fractures: What Proportion Is Caused by Fracture and Is Preventable?

Mortality After Osteoporotic Fractures: What Proportion Is Caused by Fracture and Is Preventable?

Effects of Intermittent Administration of Parathyroid Hormone and Parathyroid Hormone‐Related Protein on Fracture Healing: A Narrative Review of Animal and Human Studies

Risk of imminent fracture following a previous fracture in a Swedish database study

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