Excess Dietary Sodium Selenite Alters Apoptotic Population and Oxidative Stress Markers of Spleens in Broilers

Peng, Xi; Cui, Hengmin; He, Yaxin; Cui, Wei; Fang, Jing; Zuo, Zhicai; Deng, Junliang; Pan, Kangcheng; Zhou, Yi; Lai, Weimin

doi:10.1007/s12011-011-9160-4

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…However, it should be noted that the splenic apoptosis in TN and HS groups is 3.5% and 6.6%, respectively. Additionally, several reports found that different stressors increase the apoptosis of the spleen from approximately 4% (control group) to 6% (stressed group) in chickens [36][37][38]. Zhao et al [39] showed that the apoptosis of the spleen in the control group was 0.5%, and the stress induced by the toxin only increased the apoptosis of the spleen to 2% in chickens.…”

Section: Discussionmentioning

confidence: 99%

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

Zhuang

Zhao

et al. 2022

Marine Drugs

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With global warming, heat stress (HS) has become a worldwide concern in both humans and animals. The ameliorative effect of seaweed (Enteromorpha prolifera) derived polysaccharides (SDP) on HS-induced oxidative stress and the inflammatory response of an immune organ (spleen) was evaluated using an animal model (Gallus gallus domesticus). In total, 144 animals were used in this 4-week trial and randomly assigned to the following three groups: thermoneutral zone, HS, and HS group supplemented with 1000 mg/kg SDP. Dietary SDP improved the antioxidant capacity and reduced the malondialdehyde (MDA) of the spleen when exposed to HS, regulated via enhancing nuclear factor erythroid 2-related factor-2 (Nrf2) signaling. Furthermore, the inclusion of SDP reduced the levels of pro-inflammatory cytokines and alleviated HS-induced splenic inflammatory response by suppressing the nuclear factor-kappa B (NF-κB) p65 signaling. These findings suggest that the SDP from E. prolifera can be used as a functional food and/or feed supplement to attenuate HS-induced oxidative stress and inflammatory responses of the immune organs. Moreover, the results could contribute to the development of high-value marine products from seaweed for potential use in humans and animals, owing to their antioxidant and anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 99%

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

Zhuang

Zhao

et al. 2022

Marine Drugs

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“…Liu et al (2014) reported that in the spleen of chickens the catalase activity was decreased in cadmium group according to the control and selenium groups. Peng et al (2012) found that catalase activity in the spleen tissue of chickens fed 10 mg/kg and 15 mg/kg selenium‐containing sodium selenite decreased with time depending on the control group. In our study, it was conducted that catalase immunoreactivity was intense in the spleen of the long‐legged buzzard.…”

Section: Discussionmentioning

confidence: 99%

The structure of spleen in the long‐legged buzzard (Buteo rufinus): Histological and immunohistochemical study

Asker

Bakir

Kurtdede

et al. 2022

Anat Histol Embryol

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The spleen, which is known to play an important role in the defence of the host; it is the largest secondary lymphoid organ with mature T and B lymphocytes produced in primary lymphoid organs such as the thymus, Fabricius bursa and mammalian bone marrow (Bailey et al., 1984). It has important functions such as antibody production, blood storage, removal of erythrocytes that cannot remain in circulation, iron metabolism, blood production and immunity (Junqueira & Carneiro, 2005;Tanyolaç, 1999).The spleen in mammals is surrounded by a thin capsule containing collagen and reticular fibres and smooth muscle cells. The underdeveloped connective tissue forms trabeculae into the spleen tissue from the capsule. Large trabeculae starting from the hilum on the medial side of the spleen; splenic artery, vein, lymphatic and nerves to the spleen pulp provides entry (Davison et al., 2008;Junqueira & Carneiro, 2005). The functional parts of the spleen are divided into white pulp and red pulp (Bailey et al., 1984). A large part of the parenchyma is called 'red pulp' because of its soft consistency and rich in blood tissue. Red pulp is composed of sinusoid filled with blood and splenic cords, while white pulp consists of lymphoid nodules and the periarteriolar lymphoid sheaths (PALS) (Eşrefoğlu, 2016;Junqueira & Carneiro, 2005).In poultry, the spleen is located in the dorsal of the gonads, in the ventral of the liver and in the lateral region of the stomach. The reddishbrown spleen has a flattened dorsal and a convex ventral surface in

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“…The depression of the thymic lobule at 0.1 mg and 0.5 mg selenium (sodium selenite) supplementation was previously revealed by histological observation [15], but our measurements did not confi rm these results. Peng et al [16] reported that supplementation of 1 mg of Se (sodium selenite) in 1 kg of feed did not infl uence the percentage of apoptotic splenocytes. On the contrary, it signifi cantly decreased the relative weight of bursa and the number of lymphocytes in lymphoid nodules [17], but by pathological observation no obvious changes in the BF were observed.…”

Section: Discussionmentioning

confidence: 99%

Influence of Selenium on the Morphology of Immune System Organs in Healthy Broilers

et al. 2019

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This study aimed to establish the effect of dietary supplementation in broiler chickens of organic and inorganic selenium on the weight and structure of the thymus, bursa of Fabricius and spleen. Three dietary regimes were studied in Flex and F15 Hubbard chickens: (i) control, (ii) diets containing 0.5 mg organic selenium/kg by selenized yeast, (iii) diets supplemented with 0.5 mg ionic selenium/kg (sodium selenite). The results showed that the feed additives did not affect the relative weight of the immune system organs, i.e. bursa of Fabricius, thymus and spleen. The organic selenium in the F15 resulted in thinning of the thymic cortex and partial depletion of the lymphoid cells. Moreover, both the organic and inorganic selenium supplementation resulted in depopulation of bursal medulla from lymphocytes in the F15 group. In contrast, in Flex chickens no significant differences in histological structure and morphometric values of lymphoid organs between chickens fed organic and inorganic selenium were found.

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Excess Dietary Sodium Selenite Alters Apoptotic Population and Oxidative Stress Markers of Spleens in Broilers

Cited by 10 publications

References 26 publications

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

The structure of spleen in the long‐legged buzzard (Buteo rufinus): Histological and immunohistochemical study

Influence of Selenium on the Morphology of Immune System Organs in Healthy Broilers

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