Excess Benign Melanocytic Naevi in Renal Transplant Recipients

Szepietowski, Jacek; Wa̧sik, F; Szepietowski, T; Włodarczyk, Marcin; K, Sobczak-Radwan; Czyz, W

doi:10.1159/000246050

Cited by 43 publications

(15 citation statements)

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“…Transplant recipients are particularly predisposed to the development of skin cancer [1,2,3, 11]. Although the UV radiation is the only trigger factor of skin neoplasia which could be effectively avoided, the knowledge about the harmfulness of sunlight exposure and about the need of sun protection among the studied RTR appeared to be scanty.…”

Section: Discussionmentioning

confidence: 99%

Sun Protection in Renal Transplant Recipients: Urgent Need for Education

Szepietowski

Reich²,

Nowicka³

et al. 2005

Dermatology

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Background: Renal transplant recipients (RTR) are considered as a high-risk group of skin cancer development. Objective: The aim of the present studywas to find out the knowledge about the harmfulness of sunlight and the methods of sun protection among RTR. Material and Methods: 151 RTR (91 males and 60 females) were surveyed using a specially designed questionnaire. Results: The knowledge about the danger of sunlight exposure among RTR appeared to be very unsatisfactory. Only 40.4% of patients knew that the development of skin cancer is connected with the exposure to sunlight. Moreover, only 68.2% of investigated individuals considered RTR as a high-risk group of skin cancer development. Although 74.8% of patients were informed about the necessity of sun protection, only 11.3% could explain what the number of the SPF (sun protection factor) means. Females significantly more often knew that RTR are especially predisposed to the development of skin cancers (p = 0.0001) and significantly more frequently could explain what the SPF number means (p = 0.006). 72.8% of RTR (females significantly more often, p = 0.02) made efforts to avoid sunlight irradiation. However, only 5.3% of the examined patients routinely used creams with SPF (females significantly more often, p < 0.0001). More than a half of the patients (62.3%) did not apply any sun protection. Conclusions: The present study revealed the urgent necessity of education concerning the harmfulness of sunlight and the methods of sun protection among RTR. Moreover, it is postulated that every patient should be routinely examined by a dermatologist in a dedicated transplant patient clinic.

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Section: Discussionmentioning

confidence: 99%

Sun Protection in Renal Transplant Recipients: Urgent Need for Education

Szepietowski

Reich²,

Nowicka³

et al. 2005

Dermatology

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“…Similar findings were reported in a case-control study conducted within an adult RTR population, where the authors found an increase in the average number of melanocytic naevi in the RTR population compared with controls (93.6 Ϯ 52.2 vs 36.1 Ϯ 29.9). 19 This difference was again most pronounced on the palms and soles (with a ratio of absolute numbers of naevi between the RTR population and controls of 4.0) as well as the back/ buttocks (ratio of 3.3).…”

Section: Risk Factorsmentioning

confidence: 95%

Melanoma in organ transplant recipients: The old enemy finds a new battleground

Dinh

Chong

2007

Aust J Dermatology

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Population registry data and published studies have demonstrated that melanomas in the transplant population occur 1.6-2.5 times more commonly compared with the general population. Studies examining possible risk factors have suggested that in this patient population, there is an increased number of melanocytic naevi. Whether this phenomenon is aetiologically related to subsequent melanoma development is currently unclear. Only one study examined the prognosis of melanomas in this population. The Israel Penn International Transplant Tumor Registry has collated patient data voluntarily submitted by transplant physicians throughout the USA since 1968. Analysis of melanomas in this study found that approximately half were Breslow thickness >1.51 mm. Overall, there was a high rate of nodal and distant metastases, with poorer 1-, 3- and 5-year survival rates compared with the general population. There is a paucity of good-quality evidence regarding melanoma in organ transplant recipients. Further research involving international collaborative trials, particularly on risk factors and the prognosis of melanomas in this population, could present a more substantial evidence base from which treatment guidelines based on data could be developed.

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“…In a single western study involving 76 RTRs, the mean total number of benign melanocytic nevi was significantly higher in RTR compared to the normal population. [19] In Western studies, the incidence of cutaneous malignancies among RTR varied from 8% at 1 year to 44% at 15 years. [20][21][22] The cumulative effect of viral infections, prolonged immunosuppression and sunlight has been thought to predispose to the development of skin cancer in the transplant population.…”

Section: Skin Lesions In Rtrmentioning

confidence: 99%