Excess adiponectin in eyes with progressive ocular vascular diseases

Nishinaka, Anri; Nakamura, Shinsuke; Tanaka, Mizuki; Masuda, Tomomi; Inoue, Yuki; Yamamoto, Takumi; Imai, Takahiko; Hidaka, Yae; Shimazawa, Masamitsu; Hara, Hideaki

doi:10.1096/fj.202001740rr

Cited by 14 publications

(15 citation statements)

References 66 publications

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“…Lipocytes secrete the Adipo which monitors DM and obesity ( 24 ). Adipo plays an important role in RVO and neovascularization ( 25 ) and it might be a new treatment target. Ciliary vessels perfuse the macular region, optic nerve head and participate in the circulation of aqueous humor.…”

Section: Ischemic Crvo and Non-ischemic Crvomentioning

confidence: 99%

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Review: The Development of Risk Factors and Cytokines in Retinal Vein Occlusion

et al. 2022

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Retinal vein occlusion (RVO) is the second most prevalent retinal disease. Despite this, the pathogenic mechanisms and risk factors are not entirely clear. In this article, we review recent publications on the classification, pathogenesis, risk factors, ischemic changes, cytokines, and vital complications of RVO. Risk factors and cytokines are important for exploring the mechanisms and new treatment targets. Furthermore, risk factors are interrelated, making RVO mechanisms more complex. Cytokines act as powerful mediators of pathological conditions, such as inflammation, neovascularization, and macular edema. This review aims to summarize the updated knowledge on risk factors, cytokines of RVO and signaling in order to provide valuable insight on managing the disease.

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Section: Ischemic Crvo and Non-ischemic Crvomentioning

confidence: 99%

“…A recent study ( 50 ) showed that sodium-glucose cotransporter 2 (SGLT2) inhibitors increased the risk of RVO, as they altered the state of the blood. Adipo, adjusted obesity and DM, also increases in iCRVO ( 25 ). A study proved that the relationship between body mass index (BMI) and RVO depends on the severity of DM ( 97 ).…”

Section: Risk Factorsmentioning

confidence: 99%

Review: The Development of Risk Factors and Cytokines in Retinal Vein Occlusion

et al. 2022

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“…DR is a multifactorial chronic progressive disease, which is characterized by altered retinal microvascular blood flow, impaired function and apoptosis of pericytes and endothelial cells and increased vascular permeability, further aggravating the occlusion of capillary vessels ( 37 ). The formation of non-perfused areas results in neovascularization, leading to repeated retinal hemorrhage and fibroproliferation, recognized as the proliferative diabetic retinopathy (PDR) ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Regulatory role of miRNA‑23a in diabetic retinopathy

2021

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The present study aimed to investigate the expression of microRNA (miRNA)-23a in blood and tear samples from diabetic retinopathy (DR) patients. Blood and tear samples were obtained from 33 patients with proliferative DR. Additionally, a rat model of DR was established. Reverse transcription-quantitative PCR was used to determine vascular endothelial growth factor (VEGF) mRNA and miRNA-23a expression levels, while ELISA and western blot analysis were performed to determine protein expression levels. Bioinformatics analysis and dual luciferase reporter assay were used to predict and validate the interaction between miRNA-23a and VEGF and cell proliferative ability was assessed with the MTT assay. In comparison to control patients VEGF mRNA and protein expression levels were significantly elevated in the blood and tear samples from patients with DR, while the expression level of miRNA-23a was significantly reduced. In blood and retinal tissues from a rat model of DR, the mRNA and protein expression levels of VEGF were significantly increased, while the miRNA-23a expression level was significantly decreased relative to controls. Dual luciferase reporter assay showed that miRNA-23a bound to the 3'-untranslated region (UTR) of VEGF. Moreover, over-expression of miRNA-23a significantly reduced the expression level of VEGF and the proliferative activity of human retinal microvascular endothelial cells. The elevated VEGF expression in the blood and tears of patients with DR may be related to the reduced miRNA-23a expression. miRNA-23a may regulate microvascular growth at the retina via VEGF and contribute to DR progression.

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“…We have reported the RVO murine model, which is a model for retinal ischemic disease 12–14 . In this murine model, retinal edema and ischemic areas had formed, similar to RVO patients, and retinal ischemia continued to persist in the retina of RVO mice until 30 days after vessel occlusion 12–14 . Based on this evidence, we hypothesized that this model might form NVG in the angle, iris, and cornea due to the development of retinal ischemia.…”

Section: Introductionmentioning

confidence: 92%

“…However, there is no animal model in which NVG forms in the angle, iris, and cornea because retinal ischemia is not persistent in these animal models. We have reported the RVO murine model, which is a model for retinal ischemic disease 12–14 . In this murine model, retinal edema and ischemic areas had formed, similar to RVO patients, and retinal ischemia continued to persist in the retina of RVO mice until 30 days after vessel occlusion 12–14 .…”

Section: Introductionmentioning

confidence: 98%

The pathological association between the anterior eye segment and the retina in a murine model of neovascular glaucoma

et al. 2022

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Neovascular glaucoma (NVG) is caused by the formation of new blood vessels in the angle, iris, and cornea in retinal ischemic disease, such as proliferative diabetic retinopathy (PDR) and retinal vein occlusion (RVO), which can reduce the visual acuity. However, the pathophysiological symptoms of NVG are still not well understood because there is no model for the formation of NVG in the angle, iris, and cornea. The aim of this study was to investigate the involvement of NVG during ischemic disease, in a murine model of retinal ischemia. We evaluated the changes of the intraocular pressure (IOP) and pathological symptoms in the anterior eye segment and retina in this model, and the changes in the RNA or protein expression of vascular endothelial growth factor (VEGF) and fibrosis‐related factors were analyzed in the retina and cornea by quantitative real‐time polymerase chain reaction or western blot, respectively. Furthermore, we examined the changes in IOP after intravitreal injection of an anti‐VEGF antibody. First, NVG formed in the retinal ischemic murine model, and the IOP was elevated in mice with NVG formation. Interestingly, VEGF expression was decreased in the retina but increased in the cornea in the murine model of NVG. On the other hand, fibrosis‐related factors were increased in the retina and also significantly increased in the cornea in NVG. Moreover, the administration of anti‐VEGF antibody immediately after vessel occlusion suppressed the increase in IOP, but administration at 7 days after vessel occlusion accelerated the increase in IOP. These findings suggest that the formation of NVG may be correlated with the pathological symptoms of retinal ischemic disease, via changes in VEGF and fibrosis‐related factor expression.

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Excess adiponectin in eyes with progressive ocular vascular diseases

Cited by 14 publications

References 66 publications

Review: The Development of Risk Factors and Cytokines in Retinal Vein Occlusion

Review: The Development of Risk Factors and Cytokines in Retinal Vein Occlusion

Regulatory role of miRNA‑23a in diabetic retinopathy

The pathological association between the anterior eye segment and the retina in a murine model of neovascular glaucoma

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