Excerpts from the Pharmacology of Hormones and Related Substances

Valle, José Raymundo Enríquez-del

doi:10.1146/annurev.pa.04.040164.001533

Annu. Rev. Pharmacol.

1964

DOI: 10.1146/annurev.pa.04.040164.001533

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Excerpts from the Pharmacology of Hormones and Related Substances

José Raymundo Enríquez-del Valle¹

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1974

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“…Beside chorionic gonadotropins which act on distant organs away from uterus (for review, see VALLE, 1969), the placental steroid hormone was shown to produce a local stabilizing action on the myometrial membrane by the electrophysiological investigation (GOTO and CSAPO, 1959;THIERSCH et al, 1959;KURIYAMA, 1961;JUNG, 1964). The present paper is mainly concerned with the inhibitory effect of placental and uterine perfusates obtained from pregnant rat upon the mechanical activity of rat and mouse myometria.…”

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confidence: 99%

Inhibitory Action of Human and Rat Placental Extracts on Myometrial Activities of Mouse and Rat

Osa¹,

Katase²,

Shibata

1974

Jpn.J.Physiol

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Summary Effects of placental extract (and perfusate) obtained from humans or rats were studied by recording the electrical and mechanical activities of pregnant rat and mouse myometria. 1) Membrane potential of circular muscle cells of pregnant rat myometrium ranged between 50-60 mV. Slow potentials amounting 20-30 mV dominated the circular muscle cells in contrast to spike potentials in the longitudinal cells.2) The placental extract (as well as rat uterine perfusate) reduced the magnitude of spontaneous contractions of myometrial strips of mouse and rat. The inhibitory effect on contractile response became more pronounced when Mg ions were present in the bathing media. The extracts did not cause a significant change in the membrane potential or action potential discharge, but the compound action potential recorded extracellularly was depressed.3) The extracts potentiated the mechanical response, when the myometrial tissue from pregnant animals was treated with fl-blocking agent (10-7g/ml propranolol) or with bretylium (10-5g/ml). 4) It was argued that placenta and endometrium of the pregnant animal release bioactive substances including a certain inhibitory agent which may cause the depressant effect on the conducting mechanism of excitation, possibly through an indirect action in releasing the endogenous catecholamines.Aside from the primary action of placenta as the locus of exchange of gases, nutrients and wastes between fetal and maternal bodies, it is also known to produce several bioactive substances including hormones and antigens.

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mentioning

confidence: 99%

Inhibitory Action of Human and Rat Placental Extracts on Myometrial Activities of Mouse and Rat

Osa¹,

Katase²,

Shibata

1974

Jpn.J.Physiol

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Excerpts from the Pharmacology of Hormones and Related Substances

Cited by 1 publication

References 74 publications

Inhibitory Action of Human and Rat Placental Extracts on Myometrial Activities of Mouse and Rat

Inhibitory Action of Human and Rat Placental Extracts on Myometrial Activities of Mouse and Rat

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