Exceptional Cases of Spinal Cord Stimulation for the Treatment of Refractory Cancer-Related Pain

Bulat, Evgeny; Chakravarthy, Vikram; Crowther, Jason E.; Rakesh, Neal; Barzilai, Ori; Gulati, Amitabh

doi:10.1016/j.neurom.2022.06.002

Cited by 2 publications

(6 citation statements)

References 16 publications

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“…Additionally, the authors reported that 6 patients were discharged within 2 days after surgery and 2 patients required readmission for pain control during their follow-up period. 12 Similarly, our patient endorsed significant improvement in her pain severity following SCS to the extent that she no longer needed any analgesic agents. She was discharged on the same day after surgery, and she did not require any readmission for pain control or any further complications.…”

Section: Discussionsupporting

confidence: 56%

“…A recent single-center retrospective case series evaluated exceptional cases of refractory cancer-related pain treated with SCS at a tertiary cancer center. 12 Clinical assessment of postoperative pain was done using the NRS. 24 The average change in NRS score after SCS system implantation was –3.…”

Section: Discussionmentioning

confidence: 99%

“… 11 In cases of refractory cancer-related pain, spinal cord stimulation (SCS) has emerged as a promising method to alleviate pain and improve the quality of life in these individuals. 12 SCS is a procedure in which electrodes are placed epidurally above the spinal cord to manage pain. 13 These electrodes emit pulses that can potentially alleviate pain.…”

mentioning

confidence: 99%

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Spinal cord stimulation for chronic pain treatment following sacral chordoma resection: illustrative case

Taghlabi,

Hassan,

Somawardana

et al. 2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND Cancer-related or postoperative pain can occur following sacral chordoma resection. Despite a lack of current recommendations for cancer pain treatment, spinal cord stimulation (SCS) has demonstrated effectiveness in addressing cancer-related pain. OBSERVATIONS A 76-year-old female with a sacral chordoma underwent anterior osteotomies and partial en bloc sacrectomy. She subsequently presented with chronic pain affecting both buttocks and posterior thighs and legs, significantly impeding her daily activities. She underwent a staged epidural SCS paddle trial and permanent system placement using intraoperative neuromonitoring. The utilization of percutaneous leads was not viable because of her history of spinal fluid leakage, multiple lumbosacral surgeries, and previous complex plastic surgery closure. The patient reported a 62.5% improvement in her lower-extremity pain per the modified Quadruple Visual Analog Scale and a 50% improvement in the modified Pain and Sleep Questionnaire 3-item index during the SCS trial. Following permanent SCS system placement and removal of her externalized lead extenders, she had an uncomplicated postoperative course and reported notable improvements in her pain symptoms. LESSONS This case provides a compelling illustration of the successful treatment of chronic pain using SCS following radical sacral chordoma resection. Surgeons may consider this treatment approach in patients presenting with refractory pain following spinal tumor resection.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spinal cord stimulation for chronic pain treatment following sacral chordoma resection: illustrative case

Taghlabi,

Hassan,

Somawardana

et al. 2023

Journal of Neurosurgery: Case Lessons

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show abstract

“…Many people suffer greatly from pain, including general pain, but also cancer pain. [1,2] The incidence rate of late-stage patients was about 60%. [3] Opioid such as morphine are widely used positive effects of intestinal microecological regulation on common constipation, [18,19] the relationship between microecology and OIC has become a research hotspot.…”

Section: Introductionmentioning

confidence: 99%

“…Many people suffer greatly from pain, including general pain, but also cancer pain. [ 1,2 ] The incidence rate of late‐stage patients was about 60%. [ 3 ] Opioid such as morphine are widely used in the treatment of moderate and severe cancer pain, [ 4–6 ] but these drugs are often accompanied by opioid‐induced constipation (OIC).…”

Section: Introductionmentioning

confidence: 99%

Metabolites 13,14‐Dihydro‐15‐keto‐PGE2 Participates in Bifidobacterium animalis F1‐7 to Alleviate Opioid‐Induced Constipation by 5‐HT Pathway

Lu,

Zhou,

et al. 2023

Molecular Nutrition Food Res

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ScopePeople suffer from constipation caused by many factors, including constipation (Opioid‐Induced Constipation, OIC) during analgesic treatment. Microorganisms may be a potent solution to this problem, but the mechanism is still unclear.Methods and resultsBased on models in vivo and in vitro, the potential mechanism involving Bifidobacterium animalis F1‐7 (B. animalis F1‐7), screened in the previous studies, is explored through non‐targeted metabonomics, electrophysiological experiment and molecular level docking. The results showed that B. animalis F1‐7 effectively alleviates OIC and promotes the expression of chromogranin A (CGA) and 5‐hydroxytryptamine (5‐HT). The metabolite 13,14‐dihydro‐15‐keto‐PGE2 related to B. animalis F1‐7 is found, which has a potential improvement effect on OIC at 20 mg kg BW−1 in vivo. At 30 ng mL−1 it effectively stimulates secretion of CGA/5‐HT (408.95 ± 1.18 ng mL−1) by PC‐12 cells and changes the membrane potential potassium ion current without affecting the sodium ion current in vitro. It upregulates the target of free fatty acid receptor‐4 protein(FFAR4/β‐actin, 0.81 ± 0.02).ConclusionThe results demonstrate that metabolite 13,14‐dihydro‐15‐keto‐PGE2 participated in B. animalis F1‐7 to alleviate OIC via the 5‐HT pathway.

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Exceptional Cases of Spinal Cord Stimulation for the Treatment of Refractory Cancer-Related Pain

Cited by 2 publications

References 16 publications

Spinal cord stimulation for chronic pain treatment following sacral chordoma resection: illustrative case

Spinal cord stimulation for chronic pain treatment following sacral chordoma resection: illustrative case

Metabolites 13,14‐Dihydro‐15‐keto‐PGE2 Participates in Bifidobacterium animalis F1‐7 to Alleviate Opioid‐Induced Constipation by 5‐HT Pathway

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