Exceptional Association of a Cerebral Sinus Thrombosis and a Guillain-Barre Syndrome: A New Case Report and Review of the Literature

Abstract

Background: The association of Guillain-Barre syndrome and cerebral sinus thrombosis is uncommon. Case Presentation: We report a 37-year-old patient hospitalized in medical ICU for respiratory distress following a Guillain-Barre syndrome. He had symptomatic treatment in addition to plasma exchange. In the presence of clonic movements, a brain venography magnetic resonance showed a thrombophlebitis of the left lateral sinus, and hence a low-molecular-weight heparin treatment was begun. Immunological, thrombophilia and serological tests were negative. After a favorable evolution, he was transferred to the neurology department. Conclusion: The combination of a Guillain-Barre syndrome and a cerebral sinus thrombosis would suggest a common process. A rigorous investigation, including the use of imaging, is necessary in front of any unusual clinical sign during a GBS.

A rare case of Guillain barre syndrome with overlapping cerebral sinus venous thrombosis masquerading as acute psychosis following COVID-19 vaccination

“…With this case report we would like to state our belief that benefits of vaccination in terms of reduced morbidity and mortality outweigh the reported risk of side events like GBS and psychosis and that more research is needed before establishing or excluding an etiological relationship between both in regard to secondary mental illness (Razok et al, 2021a). Some factors known to increase the likelihood of contracting CST or GBS are: Infections, either local or systemic; nevertheless, no etiological link between the two illnesses has been discovered (Ghoummid et al, 2018).…”